Affinity Data by PubMed id=18951238

PubMed code 18951238

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM91684 (Pyrazolyl benzenesulfonamide derivative, 9a) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM91685 (Pyrazolyl benzenesulfonamide derivative, 9b) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM91679 (Pyrazolyl benzenesulfonamide derivative, 7b) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM91678 (Pyrazolyl benzenesulfonamide derivative, 7a) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91679 (Pyrazolyl benzenesulfonamide derivative, 7b) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91678 (Pyrazolyl benzenesulfonamide derivative, 7a) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91685 (Pyrazolyl benzenesulfonamide derivative, 9b) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91684 (Pyrazolyl benzenesulfonamide derivative, 9a) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair

* indicates data uncertainty>20%