Found 32 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265989
(CHEMBL462707 | N-(3-(4-methylpiperazin-1-yl)-7-(tr...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NS(=O)(=O)c3cccc(c3)[N+]([O-])=O)c2n1)C(F)(F)F Show InChI InChI=1S/C20H19F3N6O4S/c1-27-5-7-28(8-6-27)18-12-24-16-9-13(20(21,22)23)10-17(19(16)25-18)26-34(32,33)15-4-2-3-14(11-15)29(30)31/h2-4,9-12,26H,5-8H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266023
(CHEMBL515659 | N-(benzo[c][1,2,5]oxadiazol-4-ylmet...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3cccc4nonc34)c2n1)C(F)(F)F Show InChI InChI=1S/C21H20F3N7O/c1-30-5-7-31(8-6-30)18-12-26-17-10-14(21(22,23)24)9-16(20(17)27-18)25-11-13-3-2-4-15-19(13)29-32-28-15/h2-4,9-10,12,25H,5-8,11H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265954
(3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(tr...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3cccc(c3)[N+]([O-])=O)c2n1)C(F)(F)F Show InChI InChI=1S/C21H21F3N6O2/c1-28-5-7-29(8-6-28)19-13-26-18-11-15(21(22,23)24)10-17(20(18)27-19)25-12-14-3-2-4-16(9-14)30(31)32/h2-4,9-11,13,25H,5-8,12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265987
(3-(4-methylpiperazin-1-yl)-N-(4-nitrobenzyl)-7-(tr...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3ccc(cc3)[N+]([O-])=O)c2n1)C(F)(F)F Show InChI InChI=1S/C21H21F3N6O2/c1-28-6-8-29(9-7-28)19-13-26-18-11-15(21(22,23)24)10-17(20(18)27-19)25-12-14-2-4-16(5-3-14)30(31)32/h2-5,10-11,13,25H,6-9,12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265923
(5-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4NC(=O)Cc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C22H20F3N5O/c1-29-4-6-30(7-5-29)19-12-26-18-11-15(22(23,24)25)10-16(21(18)28-19)13-2-3-17-14(8-13)9-20(31)27-17/h2-3,8,10-12H,4-7,9H2,1H3,(H,27,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265988
(2-(4-methylpiperazin-1-yl)-8-(3-nitrobenzyloxy)-6-...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(OCc3cccc(c3)[N+]([O-])=O)c2n1)C(F)(F)F Show InChI InChI=1S/C21H20F3N5O3/c1-27-5-7-28(8-6-27)19-12-25-17-10-15(21(22,23)24)11-18(20(17)26-19)32-13-14-3-2-4-16(9-14)29(30)31/h2-4,9-12H,5-8,13H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265924
(1-methyl-5-(3-(4-methylpiperazin-1-yl)-7-(trifluor...)Show SMILES CN1C(=O)Cc2cc(ccc12)-c1cc(cc2ncc(nc12)N1CCN(C)CC1)C(F)(F)F Show InChI InChI=1S/C23H22F3N5O/c1-29-5-7-31(8-6-29)20-13-27-18-12-16(23(24,25)26)11-17(22(18)28-20)14-3-4-19-15(9-14)10-21(32)30(19)2/h3-4,9,11-13H,5-8,10H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266024
(CHEMBL456456 | N-(benzo[c][1,2,5]oxadiazol-5-ylmet...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3ccc4nonc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C21H20F3N7O/c1-30-4-6-31(7-5-30)19-12-26-18-10-14(21(22,23)24)9-17(20(18)27-19)25-11-13-2-3-15-16(8-13)29-32-28-15/h2-3,8-10,12,25H,4-7,11H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265922
(5-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C21H19F3N6O/c1-29-4-6-30(7-5-29)18-11-25-17-10-13(21(22,23)24)9-14(19(17)28-18)12-2-3-15-16(8-12)27-20(31)26-15/h2-3,8-11H,4-7H2,1H3,(H2,26,27,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265955
(3-(4-methylpiperazin-1-yl)-N-(2-nitrobenzyl)-7-(tr...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3ccccc3[N+]([O-])=O)c2n1)C(F)(F)F Show InChI InChI=1S/C21H21F3N6O2/c1-28-6-8-29(9-7-28)19-13-26-17-11-15(21(22,23)24)10-16(20(17)27-19)25-12-14-4-2-3-5-18(14)30(31)32/h2-5,10-11,13,25H,6-9,12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266255
(3-(4-methylpiperazin-1-yl)-5-phenyl-7-(trifluorome...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2c1)C(F)(F)F Show InChI InChI=1S/C21H20F3N3/c1-26-7-9-27(10-8-26)17-13-19-18(15-5-3-2-4-6-15)11-16(21(22,23)24)12-20(19)25-14-17/h2-6,11-14H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265990
(3-((3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3cccc(c3)C(N)=O)c2n1)C(F)(F)F Show InChI InChI=1S/C22H23F3N6O/c1-30-5-7-31(8-6-30)19-13-28-18-11-16(22(23,24)25)10-17(20(18)29-19)27-12-14-3-2-4-15(9-14)21(26)32/h2-4,9-11,13,27H,5-8,12H2,1H3,(H2,26,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265839
(4-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc(O)cc3)c2n1)C(F)(F)F Show InChI InChI=1S/C20H19F3N4O/c1-26-6-8-27(9-7-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-2-4-15(28)5-3-13/h2-5,10-12,28H,6-9H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265838
(3-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(O)c3)c2n1)C(F)(F)F Show InChI InChI=1S/C20H19F3N4O/c1-26-5-7-27(8-6-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-3-2-4-15(28)9-13/h2-4,9-12,28H,5-8H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265952
(CHEMBL462504 | N-benzyl-3-(4-methylpiperazin-1-yl)...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C21H22F3N5/c1-28-7-9-29(10-8-28)19-14-26-18-12-16(21(22,23)24)11-17(20(18)27-19)25-13-15-5-3-2-4-6-15/h2-6,11-12,14,25H,7-10,13H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266254
(2-(4-methylpiperazin-1-yl)-8-phenyl-6-(trifluorome...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C20H19F3N4/c1-26-7-9-27(10-8-26)18-13-24-17-12-15(20(21,22)23)11-16(19(17)25-18)14-5-3-2-4-6-14/h2-6,11-13H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266287
(1-(4-(8-phenyl-6-(trifluoromethyl)quinoxalin-2-yl)...)Show SMILES CC(=O)N1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C21H19F3N4O/c1-14(29)27-7-9-28(10-8-27)19-13-25-18-12-16(21(22,23)24)11-17(20(18)26-19)15-5-3-2-4-6-15/h2-6,11-13H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266329
(8-(3,4-dimethoxyphenyl)-2-(4-methylpiperazin-1-yl)...)Show SMILES COc1ccc(cc1OC)-c1cc(cc2ncc(nc12)N1CCN(C)CC1)C(F)(F)F Show InChI InChI=1S/C22H23F3N4O2/c1-28-6-8-29(9-7-28)20-13-26-17-12-15(22(23,24)25)11-16(21(17)27-20)14-4-5-18(30-2)19(10-14)31-3/h4-5,10-13H,6-9H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266330
(8-(2,3-dichlorophenyl)-2-(4-methylpiperazin-1-yl)-...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(Cl)c3Cl)c2n1)C(F)(F)F Show InChI InChI=1S/C20H17Cl2F3N4/c1-28-5-7-29(8-6-28)17-11-26-16-10-12(20(23,24)25)9-14(19(16)27-17)13-3-2-4-15(21)18(13)22/h2-4,9-11H,5-8H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265925
(3-(4-methylpiperazin-1-yl)-N-phenyl-7-(trifluorome...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(Nc3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C20H20F3N5/c1-27-7-9-28(10-8-27)18-13-24-16-11-14(20(21,22)23)12-17(19(16)26-18)25-15-5-3-2-4-6-15/h2-6,11-13,25H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265866
(8-(1H-indol-6-yl)-2-(4-methylpiperazin-1-yl)-6-(tr...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4cc[nH]c4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C22H20F3N5/c1-29-6-8-30(9-7-29)20-13-27-19-12-16(22(23,24)25)11-17(21(19)28-20)15-3-2-14-4-5-26-18(14)10-15/h2-5,10-13,26H,6-9H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266291
(6-chloro-2-(4-methylpiperazin-1-yl)-8-phenylquinox...)Show InChI InChI=1S/C19H19ClN4/c1-23-7-9-24(10-8-23)18-13-21-17-12-15(20)11-16(19(17)22-18)14-5-3-2-4-6-14/h2-6,11-13H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266290
(6-fluoro-2-(4-methylpiperazin-1-yl)-8-phenylquinox...)Show InChI InChI=1S/C19H19FN4/c1-23-7-9-24(10-8-23)18-13-21-17-12-15(20)11-16(19(17)22-18)14-5-3-2-4-6-14/h2-6,11-13H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266327
(6-methyl-2-(4-methylpiperazin-1-yl)-8-phenylquinox...)Show InChI InChI=1S/C20H22N4/c1-15-12-17(16-6-4-3-5-7-16)20-18(13-15)21-14-19(22-20)24-10-8-23(2)9-11-24/h3-7,12-14H,8-11H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265837
(3-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(c3)C(N)=O)c2n1)C(F)(F)F Show InChI InChI=1S/C21H20F3N5O/c1-28-5-7-29(8-6-28)18-12-26-17-11-15(21(22,23)24)10-16(19(17)27-18)13-3-2-4-14(9-13)20(25)30/h2-4,9-12H,5-8H2,1H3,(H2,25,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266257
(CHEMBL456722 | N,N-dimethyl-8-phenyl-6-(trifluorom...)Show InChI InChI=1S/C17H14F3N3/c1-23(2)15-10-21-14-9-12(17(18,19)20)8-13(16(14)22-15)11-6-4-3-5-7-11/h3-10H,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265953
(3-(4-methylpiperazin-1-yl)-N-phenethyl-7-(trifluor...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCCc3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C22H24F3N5/c1-29-9-11-30(12-10-29)20-15-27-19-14-17(22(23,24)25)13-18(21(19)28-20)26-8-7-16-5-3-2-4-6-16/h2-6,13-15,26H,7-12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50265840
(2-(4-methylpiperazin-1-yl)-8-(3-nitrophenyl)-6-(tr...)Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(c3)[N+]([O-])=O)c2n1)C(F)(F)F Show InChI InChI=1S/C20H18F3N5O2/c1-26-5-7-27(8-6-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-3-2-4-15(9-13)28(29)30/h2-4,9-12H,5-8H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266288
(2-(1-methylpiperidin-4-yloxy)-8-phenyl-6-(trifluor...)Show SMILES CN1CCC(CC1)Oc1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C21H20F3N3O/c1-27-9-7-16(8-10-27)28-19-13-25-18-12-15(21(22,23)24)11-17(20(18)26-19)14-5-3-2-4-6-14/h2-6,11-13,16H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266256
(8-phenyl-6-(trifluoromethyl)quinoxalin-2-amine | C...)Show InChI InChI=1S/C15H10F3N3/c16-15(17,18)10-6-11(9-4-2-1-3-5-9)14-12(7-10)20-8-13(19)21-14/h1-8H,(H2,19,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266289
(2-(4-methylpiperazin-1-yl)-8-phenylquinoxaline | C...)Show InChI InChI=1S/C19H20N4/c1-22-10-12-23(13-11-22)18-14-20-17-9-5-8-16(19(17)21-18)15-6-3-2-4-7-15/h2-9,14H,10-13H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50266328
(2-(4-methylpiperazin-1-yl)-8-phenylquinoxaline-6-c...)Show InChI InChI=1S/C20H19N5/c1-24-7-9-25(10-8-24)19-14-22-18-12-15(13-21)11-17(20(18)23-19)16-5-3-2-4-6-16/h2-6,11-12,14H,7-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Celltech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay |
Bioorg Med Chem Lett 19: 397-400 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC |
More data for this
Ligand-Target Pair | |
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