Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bile acid receptor (Homo sapiens (Human)) | BDBM28542 (WAY-362450 | XL335 | propan-2-yl 3-[(3,4-difluorop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28534 (Azepino[4,5-b]indole, 6e | ethyl 3-[(4-chloropheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 73 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28537 (Azepino[4,5-b]indole, 6h | ethyl 3-[(4-fluoropheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 22 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28530 (Azepino[4,5-b]indole, 6a | propan-2-yl 3-[(4-fluor...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 500 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28532 (Azepino[4,5-b]indole, 6c | butyl 3-[(4-fluoropheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28538 (Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28541 (Azepino[4,5-b]indole, 6l | propan-2-yl 3-[(4-fluor...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28531 (Azepino[4,5-b]indole, 6b | propyl 3-[(4-fluorophen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 500 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28536 (Azepino[4,5-b]indole, 6g | ethyl 3-[(3,4-difluorop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28533 (Azepino[4,5-b]indole, 6d | ethyl 3-[(4-fluoropheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 57 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28529 (Azepino[4,5-b]indole, 1 | ethyl 3-[(4-fluorophenyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28539 (Azepino[4,5-b]indole, 6j | ethyl 3-[(4-chloropheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28540 (Azepino[4,5-b]indole, 6k | ethyl 3-[(4-methoxyphen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 29 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM28535 (Azepino[4,5-b]indole, 6f | ethyl 3-[(4-methoxyphen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair |