Affinity Data by PubMed id=19246009

PubMed code 19246009

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ATP-dependent RNA helicase RhlE (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM13307 (1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	37
Duke University Medical Center					Assay Description Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair
ATP-dependent RNA helicase RhlE (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM31423 (ethylenediamine scaffold, 4) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.5	37
Duke University Medical Center					Assay Description Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair
ATP-dependent RNA helicase RhlE (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM31424 (ethylenediamine scaffold, 5) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	37
Duke University Medical Center					Assay Description Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair
ATP-dependent RNA helicase RhlE (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM31425 (ethylenediamine scaffold, 7) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	37
Duke University Medical Center					Assay Description Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13307 (1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)
ATP-dependent RNA helicase RhlE (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM31426 (ethylenediamine scaffold, 10) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	7.5	37
Duke University Medical Center					Assay Description Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM31425 (ethylenediamine scaffold, 7) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM31426 (ethylenediamine scaffold, 10) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM31423 (ethylenediamine scaffold, 4) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM31424 (ethylenediamine scaffold, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	4.05E+3	n/a	n/a	n/a	n/a	7.7	30
Duke University Medical Center					Assay Description In vitro inhibition assay of human PFT was done by measuring the incorporation of [3H] FPP (Amersham Biosciences, Piscataway, NJ) into wild type H-Ra...				Chem Biol 16: 181-92 (2009) Article DOI: 10.1016/j.chembiol.2009.01.014 BindingDB Entry DOI: 10.7270/Q22F7KR8
Duke University Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%