Affinity Data by PubMed id=19261472

PubMed code 19261472

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Stromelysin-1 (Homo sapiens (Human))	BDBM50241504 (3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50278741 (3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...) Show SMILES COc1ccc(CNC(=O)c2oc(C)cc(=O)c2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50278742 (3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...) Show SMILES Cc1cc(=O)c(O)c(o1)C(=O)NCc1ccc(O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50278743 (AM-2S \| CHEMBL470194 \| N-(biphenyl-4-ylmethyl)-3-h...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50241504 (3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP2 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50278812 (5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid (bip...) Show SMILES Oc1coc(cc1=S)C(=O)NCc1ccc(cc1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50278813 (5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid 4-me...) Show SMILES COc1ccc(CNC(=O)c2cc(=S)c(O)co2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50278812 (5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid (bip...) Show SMILES Oc1coc(cc1=S)C(=O)NCc1ccc(cc1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP2 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50278740 (3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic ...) Show SMILES COc1ccc(CNC(=O)c2oc(C)cc(=S)c2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP3 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50278740 (3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic ...) Show SMILES COc1ccc(CNC(=O)c2oc(C)cc(=S)c2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP2 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50278814 (CHEMBL498272 \| N-(biphenyl-4-ylmethyl)-5-hydroxy-2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP2 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50278740 (3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic ...) Show SMILES COc1ccc(CNC(=O)c2oc(C)cc(=S)c2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP1 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50278070 (5-Hydroxy-2-methyl-4-thioxo-4H-pyran-3-carboxylic ...) Show SMILES COc1ccc(CNC(=O)c2c(C)occ(O)c2=S)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP2 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50278130 (2-{[(Biphenyl-4-ylmethyl)-amino]-methyl}-3-hydroxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.77E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP2 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50278812 (5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid (bip...) Show SMILES Oc1coc(cc1=S)C(=O)NCc1ccc(cc1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP1 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50241504 (3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MMP1 catalytic domain by fluorescent substrate assay				Bioorg Med Chem Lett 19: 1970-6 (2009) Article DOI: 10.1016/j.bmcl.2009.02.044 BindingDB Entry DOI: 10.7270/Q2H99536
University of California Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%