Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50278740 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_564425 (CHEMBL964230) |
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IC50 | 30000±n/a nM |
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Citation | Yan, YL; Miller, MT; Cao, Y; Cohen, SM Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship. Bioorg Med Chem Lett19:1970-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50278740 |
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n/a |
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Name | BDBM50278740 |
Synonyms: | 3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic acid 4-methoxy-benzyl ester | CHEMBL470830 |
Type | Small organic molecule |
Emp. Form. | C15H15NO4S |
Mol. Mass. | 305.349 |
SMILES | COc1ccc(CNC(=O)c2oc(C)cc(=S)c2O)cc1 |
Structure |
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