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PubMed code 19883081

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a 3.60n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299964
PNG
(4-Fluoro-N-{[2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluor...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)
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n/an/a 4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 3


(Mus musculus)		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse ELOVL3

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299963
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-4-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-14-4-1-11(2-5-14)17(29)25-10-19(20(22,23)24)15-7-12(13-8-26-27-9-13)3-6-16(15)28-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,27)(H,28,30)
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n/an/a 20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299963
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-4-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-14-4-1-11(2-5-14)17(29)25-10-19(20(22,23)24)15-7-12(13-8-26-27-9-13)3-6-16(15)28-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,27)(H,28,30)
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n/an/a 22n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299963
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-4-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-14-4-1-11(2-5-14)17(29)25-10-19(20(22,23)24)15-7-12(13-8-26-27-9-13)3-6-16(15)28-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,27)(H,28,30)
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n/an/a 22n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299948
PNG
(CHEMBL572158 | N-{[(+)-6-Chloro-2-oxo-4-(trifluoro...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-10-3-6-13-12(7-10)16(17(20,21)22,27-15(26)24-13)8-23-14(25)9-1-4-11(19)5-2-9/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a 26n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299965
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-1-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1cccn1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-2-12(3-5-13)17(29)25-11-19(20(22,23)24)15-10-14(28-9-1-8-26-28)6-7-16(15)27-18(30)31-19/h1-10H,11H2,(H,25,29)(H,27,30)
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n/an/a 26n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299965
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-1-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1cccn1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-2-12(3-5-13)17(29)25-11-19(20(22,23)24)15-10-14(28-9-1-8-26-28)6-7-16(15)27-18(30)31-19/h1-10H,11H2,(H,25,29)(H,27,30)
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n/an/a 26n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299948
PNG
(CHEMBL572158 | N-{[(+)-6-Chloro-2-oxo-4-(trifluoro...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-10-3-6-13-12(7-10)16(17(20,21)22,27-15(26)24-13)8-23-14(25)9-1-4-11(19)5-2-9/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a 26n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299948
PNG
(CHEMBL572158 | N-{[(+)-6-Chloro-2-oxo-4-(trifluoro...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-10-3-6-13-12(7-10)16(17(20,21)22,27-15(26)24-13)8-23-14(25)9-1-4-11(19)5-2-9/h1-7H,8H2,(H,23,25)(H,24,26)
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Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299965
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-1-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1cccn1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-2-12(3-5-13)17(29)25-11-19(20(22,23)24)15-10-14(28-9-1-8-26-28)6-7-16(15)27-18(30)31-19/h1-10H,11H2,(H,25,29)(H,27,30)
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n/an/a 29n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299946
PNG
(1-{[(-)-6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dih...)
Show SMILES Fc1ccc(NC(=O)NCC2(OC(=O)Nc3ccc(Cl)cc23)C(F)(F)F)cc1
Show InChI InChI=1S/C17H12ClF4N3O3/c18-9-1-6-13-12(7-9)16(17(20,21)22,28-15(27)25-13)8-23-14(26)24-11-4-2-10(19)3-5-11/h1-7H,8H2,(H,25,27)(H2,23,24,26)
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n/an/a 31n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299946
PNG
(1-{[(-)-6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dih...)
Show SMILES Fc1ccc(NC(=O)NCC2(OC(=O)Nc3ccc(Cl)cc23)C(F)(F)F)cc1
Show InChI InChI=1S/C17H12ClF4N3O3/c18-9-1-6-13-12(7-9)16(17(20,21)22,28-15(27)25-13)8-23-14(26)24-11-4-2-10(19)3-5-11/h1-7H,8H2,(H,25,27)(H2,23,24,26)
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n/an/a 33n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299946
PNG
(1-{[(-)-6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dih...)
Show SMILES Fc1ccc(NC(=O)NCC2(OC(=O)Nc3ccc(Cl)cc23)C(F)(F)F)cc1
Show InChI InChI=1S/C17H12ClF4N3O3/c18-9-1-6-13-12(7-9)16(17(20,21)22,28-15(27)25-13)8-23-14(26)24-11-4-2-10(19)3-5-11/h1-7H,8H2,(H,25,27)(H2,23,24,26)
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Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299951
PNG
(CHEMBL582825 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES Cc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O3/c1-10-2-4-11(5-3-10)15(25)23-9-17(18(20,21)22)13-8-12(19)6-7-14(13)24-16(26)27-17/h2-8H,9H2,1H3,(H,23,25)(H,24,26)
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n/an/a 38n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299969
PNG
(4-Fluoro-N-{[2-oxo-6-(2-oxopyrrolidin-1-yl)-4-(tri...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)N1CCCC1=O)C(F)(F)F
Show InChI InChI=1S/C21H17F4N3O4/c22-13-5-3-12(4-6-13)18(30)26-11-20(21(23,24)25)15-10-14(28-9-1-2-17(28)29)7-8-16(15)27-19(31)32-20/h3-8,10H,1-2,9,11H2,(H,26,30)(H,27,31)
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n/an/a 39n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299963
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-4-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-14-4-1-11(2-5-14)17(29)25-10-19(20(22,23)24)15-7-12(13-8-26-27-9-13)3-6-16(15)28-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,27)(H,28,30)
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n/an/a 50n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299965
PNG
(4-Fluoro-N-{[(+)-2-oxo-6-(1H-pyrazol-1-yl)-4-(trif...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1cccn1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-2-12(3-5-13)17(29)25-11-19(20(22,23)24)15-10-14(28-9-1-8-26-28)6-7-16(15)27-18(30)31-19/h1-10H,11H2,(H,25,29)(H,27,30)
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n/an/a 58n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299970
PNG
(4-Fluoro-N-{[2-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)-4...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)N1CCOC1=O)C(F)(F)F
Show InChI InChI=1S/C20H15F4N3O5/c21-12-3-1-11(2-4-12)16(28)25-10-19(20(22,23)24)14-9-13(27-7-8-31-18(27)30)5-6-15(14)26-17(29)32-19/h1-6,9H,7-8,10H2,(H,25,28)(H,26,29)
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n/an/a 67n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299959
PNG
(4-Fluoro-N-{[2-oxo-4-(trifluoromethyl)-1,4-dihydro...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C17H12F4N2O3/c18-11-7-5-10(6-8-11)14(24)22-9-16(17(19,20)21)12-3-1-2-4-13(12)23-15(25)26-16/h1-8H,9H2,(H,22,24)(H,23,25)
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n/an/a 95n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299966
PNG
(4-Fluoro-N-{[2-oxo-6-(1H-1,2,4-triazol-5-yl)-4-(tr...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1nnc[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H13F4N5O3/c20-12-4-1-10(2-5-12)16(29)24-8-18(19(21,22)23)13-7-11(15-25-9-26-28-15)3-6-14(13)27-17(30)31-18/h1-7,9H,8H2,(H,24,29)(H,27,30)(H,25,26,28)
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n/an/a 97n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299961
PNG
(4-Fluoro-N-{[2-oxo-6-(2-oxopyridin-1(2H)-yl)-4-(tr...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1ccccc1=O)C(F)(F)F
Show InChI InChI=1S/C22H15F4N3O4/c23-14-6-4-13(5-7-14)19(31)27-12-21(22(24,25)26)16-11-15(29-10-2-1-3-18(29)30)8-9-17(16)28-20(32)33-21/h1-11H,12H2,(H,27,31)(H,28,32)
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n/an/a 106n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299962
PNG
(4-Fluoro-N-{[6-(isoxazol-4-yl)-2-oxo-4-(trifluorom...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1ccon1)C(F)(F)F
Show InChI InChI=1S/C20H13F4N3O4/c21-13-4-1-11(2-5-13)17(28)25-10-19(20(22,23)24)14-9-12(15-7-8-30-27-15)3-6-16(14)26-18(29)31-19/h1-9H,10H2,(H,25,28)(H,26,29)
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n/an/a 121n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 3


(Homo sapiens (Human))		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL3

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299948
PNG
(CHEMBL572158 | N-{[(+)-6-Chloro-2-oxo-4-(trifluoro...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-10-3-6-13-12(7-10)16(17(20,21)22,27-15(26)24-13)8-23-14(25)9-1-4-11(19)5-2-9/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a 131n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299940
PNG
(CHEMBL578605 | [6-Chloro-2-oxo-4-(trifluoromethyl)...)
Show SMILES Fc1ccc(NC(=O)OCC2(OC(=O)Nc3ccc(Cl)cc23)C(F)(F)F)cc1
Show InChI InChI=1S/C17H11ClF4N2O4/c18-9-1-6-13-12(7-9)16(17(20,21)22,28-15(26)24-13)8-27-14(25)23-11-4-2-10(19)3-5-11/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a 142n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299949
PNG
(CHEMBL574146 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES Fc1cccc(c1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-10-4-5-13-12(7-10)16(17(20,21)22,27-15(26)24-13)8-23-14(25)9-2-1-3-11(19)6-9/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a 261n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Mus musculus)		BDBM50299946
PNG
(1-{[(-)-6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dih...)
Show SMILES Fc1ccc(NC(=O)NCC2(OC(=O)Nc3ccc(Cl)cc23)C(F)(F)F)cc1
Show InChI InChI=1S/C17H12ClF4N3O3/c18-9-1-6-13-12(7-9)16(17(20,21)22,28-15(27)25-13)8-23-14(26)24-11-4-2-10(19)3-5-11/h1-7H,8H2,(H,25,27)(H2,23,24,26)
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n/an/a 377n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299952
PNG
(CHEMBL569176 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES Cc1cccc(c1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O3/c1-10-3-2-4-11(7-10)15(25)23-9-17(18(20,21)22)13-8-12(19)5-6-14(13)24-16(26)27-17/h2-8H,9H2,1H3,(H,23,25)(H,24,26)
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n/an/a 437n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299968
PNG
(4-Fluoro-N-{[6-(1H-imidazol-2-yl)-2-oxo-4-(trifluo...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1ncc[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)27-10-19(20(22,23)24)14-9-12(16-25-7-8-26-16)3-6-15(14)28-18(30)31-19/h1-9H,10H2,(H,25,26)(H,27,29)(H,28,30)
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n/an/a 537n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299950
PNG
(CHEMBL572159 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES Fc1ccccc1C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-9-5-6-13-11(7-9)16(17(20,21)22,27-15(26)24-13)8-23-14(25)10-3-1-2-4-12(10)19/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a 539n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299954
PNG
(CHEMBL583523 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES COc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O4/c1-27-12-5-2-10(3-6-12)15(25)23-9-17(18(20,21)22)13-8-11(19)4-7-14(13)24-16(26)28-17/h2-8H,9H2,1H3,(H,23,25)(H,24,26)
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n/an/a 558n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299967
PNG
(4-Fluoro-N-{[2-oxo-6-(1H-1,2,4-triazol-1-yl)-4-(tr...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-n1cncn1)C(F)(F)F
Show InChI InChI=1S/C19H13F4N5O3/c20-12-3-1-11(2-4-12)16(29)25-8-18(19(21,22)23)14-7-13(28-10-24-9-26-28)5-6-15(14)27-17(30)31-18/h1-7,9-10H,8H2,(H,25,29)(H,27,30)
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n/an/a 572n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299947
PNG
(CHEMBL583461 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES Fc1ccc(CC(=O)NCC2(OC(=O)Nc3ccc(Cl)cc23)C(F)(F)F)cc1
Show InChI InChI=1S/C18H13ClF4N2O3/c19-11-3-6-14-13(8-11)17(18(21,22)23,28-16(27)25-14)9-24-15(26)7-10-1-4-12(20)5-2-10/h1-6,8H,7,9H2,(H,24,26)(H,25,27)
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n/an/a 648n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299955
PNG
(CHEMBL566965 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C18H11ClF6N2O3/c19-11-5-6-13-12(7-11)16(18(23,24)25,30-15(29)27-13)8-26-14(28)9-1-3-10(4-2-9)17(20,21)22/h1-7H,8H2,(H,26,28)(H,27,29)
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n/an/a 813n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299953
PNG
(CHEMBL569177 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES Cc1ccccc1C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O3/c1-10-4-2-3-5-12(10)15(25)23-9-17(18(20,21)22)13-8-11(19)6-7-14(13)24-16(26)27-17/h2-8H,9H2,1H3,(H,23,25)(H,24,26)
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n/an/a 971n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299941
PNG
((6-chloro-4-methyl-2-oxo-1,4-dihydro-2H-3,1-benzox...)
Show SMILES CC1(COC(=O)Nc2ccc(F)cc2)OC(=O)Nc2ccc(Cl)cc12
Show InChI InChI=1S/C17H14ClFN2O4/c1-17(9-24-15(22)20-12-5-3-11(19)4-6-12)13-8-10(18)2-7-14(13)21-16(23)25-17/h2-8H,9H2,1H3,(H,20,22)(H,21,23)
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n/an/a 1.36E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299944
PNG
((6-chloro-4-cyclopropyl-2-oxo-1,4-dihydro-2H-3,1-b...)
Show SMILES Fc1ccc(NC(=O)OCC2(OC(=O)Nc3ccc(Cl)cc23)C2CC2)cc1
Show InChI InChI=1S/C19H16ClFN2O4/c20-12-3-8-16-15(9-12)19(11-1-2-11,27-18(25)23-16)10-26-17(24)22-14-6-4-13(21)5-7-14/h3-9,11H,1-2,10H2,(H,22,24)(H,23,25)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299960
PNG
(4-Fluoro-N-{[2-oxo-6-phenyl-4-(trifluoromethyl)-1,...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(cc12)-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C23H16F4N2O3/c24-17-9-6-15(7-10-17)20(30)28-13-22(23(25,26)27)18-12-16(14-4-2-1-3-5-14)8-11-19(18)29-21(31)32-22/h1-12H,13H2,(H,28,30)(H,29,31)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299956
PNG
(CHEMBL569397 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES CC(C)c1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C20H18ClF3N2O3/c1-11(2)12-3-5-13(6-4-12)17(27)25-10-19(20(22,23)24)15-9-14(21)7-8-16(15)26-18(28)29-19/h3-9,11H,10H2,1-2H3,(H,25,27)(H,26,28)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299942
PNG
((6-chloro-4-ethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxa...)
Show SMILES CCC1(COC(=O)Nc2ccc(F)cc2)OC(=O)Nc2ccc(Cl)cc12
Show InChI InChI=1S/C18H16ClFN2O4/c1-2-18(10-25-16(23)21-13-6-4-12(20)5-7-13)14-9-11(19)3-8-15(14)22-17(24)26-18/h3-9H,2,10H2,1H3,(H,21,23)(H,22,24)
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n/an/a 2.26E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299943
PNG
((6-chloro-2-oxo-4-(propan-2-yl)-1,4-dihydro-2H-3,1...)
Show SMILES CC(C)C1(COC(=O)Nc2ccc(F)cc2)OC(=O)Nc2ccc(Cl)cc12
Show InChI InChI=1S/C19H18ClFN2O4/c1-11(2)19(10-26-17(24)22-14-6-4-13(21)5-7-14)15-9-12(20)3-8-16(15)23-18(25)27-19/h3-9,11H,10H2,1-2H3,(H,22,24)(H,23,25)
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n/an/a 5.03E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 1


(Homo sapiens (Human))		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL1

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299948
PNG
(CHEMBL572158 | N-{[(+)-6-Chloro-2-oxo-4-(trifluoro...)
Show SMILES Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N2O3/c18-10-3-6-13-12(7-10)16(17(20,21)22,27-15(26)24-13)8-23-14(25)9-1-4-11(19)5-2-9/h1-7H,8H2,(H,23,25)(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299945
PNG
((6-chloro-2-oxo-4-phenyl-1,4-dihydro-2H-3,1-benzox...)
Show SMILES Fc1ccc(NC(=O)OCC2(OC(=O)Nc3ccc(Cl)cc23)c2ccccc2)cc1
Show InChI InChI=1S/C22H16ClFN2O4/c23-15-6-11-19-18(12-15)22(30-21(28)26-19,14-4-2-1-3-5-14)13-29-20(27)25-17-9-7-16(24)8-10-17/h1-12H,13H2,(H,25,27)(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 5


(Homo sapiens (Human))		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL5

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299957
PNG
(CHEMBL569398 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES FC(F)(F)C1(CNC(=O)c2ccc(cc2)-c2ccccc2)OC(=O)Nc2ccc(Cl)cc12
Show InChI InChI=1S/C23H16ClF3N2O3/c24-17-10-11-19-18(12-17)22(23(25,26)27,32-21(31)29-19)13-28-20(30)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-12H,13H2,(H,28,30)(H,29,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 6


(Homo sapiens (Human))		BDBM50299958
PNG
(CHEMBL571935 | N-{[6-Chloro-2-oxo-4-(trifluorometh...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O5S/c1-30(27,28)12-5-2-10(3-6-12)15(25)23-9-17(18(20,21)22)13-8-11(19)4-7-14(13)24-16(26)29-17/h2-8H,9H2,1H3,(H,23,25)(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
Elongation of very long chain fatty acids protein 2


(Homo sapiens (Human))		BDBM50299971
PNG
(4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-...)
Show SMILES Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r|
Show InChI InChI=1S/C20H14F4N4O3/c21-13-4-1-11(2-5-13)17(29)25-10-19(20(22,23)24)14-9-12(15-7-8-26-28-15)3-6-16(14)27-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,28)(H,27,30)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ELOVL2

J Med Chem 52: 7289-300 (2009)


Article DOI: 10.1021/jm900915x
BindingDB Entry DOI: 10.7270/Q2XK8FMB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%