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PubMed code 20031403

Compile data set for download or QSAR
Found 113 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309399
PNG
(2-(2-(4-chlorobenzyl)-4-(4-phenoxyphenyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H18ClNO3S/c25-18-10-6-16(7-11-18)14-22-26-24(21(30-22)15-23(27)28)17-8-12-20(13-9-17)29-19-4-2-1-3-5-19/h1-13H,14-15H2,(H,27,28)
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309401
PNG
(2-(2-(2-(benzo[d][1,3]dioxol-5-yl)benzyl)-4-(4-flu...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccc3OCOc3c2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H18FNO4S/c26-18-8-5-15(6-9-18)25-22(13-24(28)29)32-23(27-25)12-16-3-1-2-4-19(16)17-7-10-20-21(11-17)31-14-30-20/h1-11H,12-14H2,(H,28,29)
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n/an/a 24n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309408
PNG
(2-(2-(biphenyl-2-ylmethyl)-4-(4-fluorophenyl)thiaz...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccccc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C24H18FNO2S/c25-19-12-10-17(11-13-19)24-21(15-23(27)28)29-22(26-24)14-18-8-4-5-9-20(18)16-6-2-1-3-7-16/h1-13H,14-15H2,(H,27,28)
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n/an/a 24n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309441
PNG
(2-(4-(biphenyl-4-yl)-2-phenylthiazol-5-yl)acetic a...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(cc1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H17NO2S/c25-21(26)15-20-22(24-23(27-20)19-9-5-2-6-10-19)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-14H,15H2,(H,25,26)
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n/an/a 38n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309441
PNG
(2-(4-(biphenyl-4-yl)-2-phenylthiazol-5-yl)acetic a...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(cc1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H17NO2S/c25-21(26)15-20-22(24-23(27-20)19-9-5-2-6-10-19)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-14H,15H2,(H,25,26)
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n/an/a 38n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309404
PNG
(2-(4-(4-fluorophenyl)-2-((3'-methoxybiphenyl-2-yl)...)
Show SMILES COc1cccc(c1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-7-4-6-17(13-20)21-8-3-2-5-18(21)14-23-27-25(22(31-23)15-24(28)29)16-9-11-19(26)12-10-16/h2-13H,14-15H2,1H3,(H,28,29)
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n/an/a 40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309398
PNG
(2-(4-(4-chlorophenyl)-2-(naphthalen-2-ylmethyl)thi...)
Show SMILES OC(=O)Cc1sc(Cc2ccc3ccccc3c2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H16ClNO2S/c23-18-9-7-16(8-10-18)22-19(13-21(25)26)27-20(24-22)12-14-5-6-15-3-1-2-4-17(15)11-14/h1-11H,12-13H2,(H,25,26)
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n/an/a 41n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309269
PNG
(2-(2-(biphenyl-2-ylmethyl)-4-(4-chlorophenyl)thiaz...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H18ClNO2S/c25-19-12-10-17(11-13-19)24-21(15-23(27)28)29-22(26-24)14-18-8-4-5-9-20(18)16-6-2-1-3-7-16/h1-13H,14-15H2,(H,27,28)
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n/an/a 41n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309428
PNG
(2-(2-(2-methoxyphenylamino)-4-(4-phenoxyphenyl)thi...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H20N2O4S/c1-29-20-10-6-5-9-19(20)25-24-26-23(21(31-24)15-22(27)28)16-11-13-18(14-12-16)30-17-7-3-2-4-8-17/h2-14H,15H2,1H3,(H,25,26)(H,27,28)
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n/an/a 49n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309414
PNG
(2-(2-(4-chlorobenzyl)-4-(4-chlorophenyl)thiazol-5-...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H13Cl2NO2S/c19-13-5-1-11(2-6-13)9-16-21-18(15(24-16)10-17(22)23)12-3-7-14(20)8-4-12/h1-8H,9-10H2,(H,22,23)
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n/an/a 50n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309399
PNG
(2-(2-(4-chlorobenzyl)-4-(4-phenoxyphenyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H18ClNO3S/c25-18-10-6-16(7-11-18)14-22-26-24(21(30-22)15-23(27)28)17-8-12-20(13-9-17)29-19-4-2-1-3-5-19/h1-13H,14-15H2,(H,27,28)
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n/an/a 66n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309405
PNG
(2-(4-(4-fluorophenyl)-2-((4'-methoxybiphenyl-2-yl)...)
Show SMILES COc1ccc(cc1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-12-8-16(9-13-20)21-5-3-2-4-18(21)14-23-27-25(22(31-23)15-24(28)29)17-6-10-19(26)11-7-17/h2-13H,14-15H2,1H3,(H,28,29)
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n/an/a 72n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309421
PNG
(2-(4-(4-phenoxyphenyl)-2-(phenylamino)thiazol-5-yl...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H18N2O3S/c26-21(27)15-20-22(25-23(29-20)24-17-7-3-1-4-8-17)16-11-13-19(14-12-16)28-18-9-5-2-6-10-18/h1-14H,15H2,(H,24,25)(H,26,27)
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n/an/a 84n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309415
PNG
(2-(2-(4-chlorobenzyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccccc1
Show InChI InChI=1S/C18H14ClNO2S/c19-14-8-6-12(7-9-14)10-16-20-18(13-4-2-1-3-5-13)15(23-16)11-17(21)22/h1-9H,10-11H2,(H,21,22)
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n/an/a 88n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309420
PNG
(2-(2-(4-fluorophenylamino)-4-(4-phenoxyphenyl)thia...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(F)cc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17FN2O3S/c24-16-8-10-17(11-9-16)25-23-26-22(20(30-23)14-21(27)28)15-6-12-19(13-7-15)29-18-4-2-1-3-5-18/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a 89n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309270
PNG
(2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H16ClNO3S/c24-17-10-6-15(7-11-17)22-20(14-21(26)27)29-23(25-22)16-8-12-19(13-9-16)28-18-4-2-1-3-5-18/h1-13H,14H2,(H,26,27)
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n/an/a 93n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309270
PNG
(2-(4-(4-chlorophenyl)-2-(4-phenoxyphenyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H16ClNO3S/c24-17-10-6-15(7-11-17)22-20(14-21(26)27)29-23(25-22)16-8-12-19(13-9-16)28-18-4-2-1-3-5-18/h1-13H,14H2,(H,26,27)
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n/an/a 93n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309416
PNG
(2-(2-(naphthalen-2-ylamino)-4-(4-phenoxyphenyl)thi...)
Show SMILES OC(=O)Cc1sc(Nc2ccc3ccccc3c2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H20N2O3S/c30-25(31)17-24-26(19-11-14-23(15-12-19)32-22-8-2-1-3-9-22)29-27(33-24)28-21-13-10-18-6-4-5-7-20(18)16-21/h1-16H,17H2,(H,28,29)(H,30,31)
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n/an/a 94n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309259
PNG
(2-(4-(4-chlorophenyl)-2-(phenylamino)thiazol-5-yl)...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13ClN2O2S/c18-12-8-6-11(7-9-12)16-14(10-15(21)22)23-17(20-16)19-13-4-2-1-3-5-13/h1-9H,10H2,(H,19,20)(H,21,22)
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n/an/a 100n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309418
PNG
(2-(2-(2-chlorophenylamino)-4-(4-phenoxyphenyl)thia...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2Cl)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17ClN2O3S/c24-18-8-4-5-9-19(18)25-23-26-22(20(30-23)14-21(27)28)15-10-12-17(13-11-15)29-16-6-2-1-3-7-16/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a 130n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309410
PNG
(2-(2-benzyl-4-(4-fluorophenyl)thiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H14FNO2S/c19-14-8-6-13(7-9-14)18-15(11-17(21)22)23-16(20-18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,21,22)
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n/an/a 140n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309437
PNG
(2-(2-(4-phenoxyphenyl)-4-phenylthiazol-5-yl)acetic...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17NO3S/c25-21(26)15-20-22(16-7-3-1-4-8-16)24-23(28-20)17-11-13-19(14-12-17)27-18-9-5-2-6-10-18/h1-14H,15H2,(H,25,26)
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n/an/a 160n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309437
PNG
(2-(2-(4-phenoxyphenyl)-4-phenylthiazol-5-yl)acetic...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17NO3S/c25-21(26)15-20-22(16-7-3-1-4-8-16)24-23(28-20)17-11-13-19(14-12-17)27-18-9-5-2-6-10-18/h1-14H,15H2,(H,25,26)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309402
PNG
(2-(4-(4-fluorophenyl)-2-((3'-(trifluoromethoxy)bip...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2cccc(OC(F)(F)F)c2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H17F4NO3S/c26-18-10-8-15(9-11-18)24-21(14-23(31)32)34-22(30-24)13-17-4-1-2-7-20(17)16-5-3-6-19(12-16)33-25(27,28)29/h1-12H,13-14H2,(H,31,32)
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n/an/a 160n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309400
PNG
(2-(4-(4-chlorophenyl)-2-(2-phenoxybenzyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2Oc2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H18ClNO3S/c25-18-12-10-16(11-13-18)24-21(15-23(27)28)30-22(26-24)14-17-6-4-5-9-20(17)29-19-7-2-1-3-8-19/h1-13H,14-15H2,(H,27,28)
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n/an/a 160n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309407
PNG
(2-(2-((4'-cyanobiphenyl-2-yl)methyl)-4-(4-fluoroph...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccc(cc2)C#N)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H17FN2O2S/c26-20-11-9-18(10-12-20)25-22(14-24(29)30)31-23(28-25)13-19-3-1-2-4-21(19)17-7-5-16(15-27)6-8-17/h1-12H,13-14H2,(H,29,30)
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n/an/a 170n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309403
PNG
(2-(4-(4-fluorophenyl)-2-((2'-methoxybiphenyl-2-yl)...)
Show SMILES COc1ccccc1-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-21-9-5-4-8-20(21)19-7-3-2-6-17(19)14-23-27-25(22(31-23)15-24(28)29)16-10-12-18(26)13-11-16/h2-13H,14-15H2,1H3,(H,28,29)
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n/an/a 170n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309410
PNG
(2-(2-benzyl-4-(4-fluorophenyl)thiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H14FNO2S/c19-14-8-6-13(7-9-14)18-15(11-17(21)22)23-16(20-18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,21,22)
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n/an/a 180n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309255
PNG
(2-(2-benzyl-4-(4-chlorophenyl)thiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14ClNO2S/c19-14-8-6-13(7-9-14)18-15(11-17(21)22)23-16(20-18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,21,22)
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n/an/a 180n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309407
PNG
(2-(2-((4'-cyanobiphenyl-2-yl)methyl)-4-(4-fluoroph...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccc(cc2)C#N)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H17FN2O2S/c26-20-11-9-18(10-12-20)25-22(14-24(29)30)31-23(28-25)13-19-3-1-2-4-21(19)17-7-5-16(15-27)6-8-17/h1-12H,13-14H2,(H,29,30)
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n/an/a 190n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309447
PNG
(2-(2-(4-chlorophenyl)-4-(4-methoxyphenyl)thiazol-5...)
Show SMILES COc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14ClNO3S/c1-23-14-8-4-11(5-9-14)17-15(10-16(21)22)24-18(20-17)12-2-6-13(19)7-3-12/h2-9H,10H2,1H3,(H,21,22)
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n/an/a 210n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309419
PNG
(2-(2-(2-fluorophenylamino)-4-(4-phenoxyphenyl)thia...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2F)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17FN2O3S/c24-18-8-4-5-9-19(18)25-23-26-22(20(30-23)14-21(27)28)15-10-12-17(13-11-15)29-16-6-2-1-3-7-16/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a 210n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309414
PNG
(2-(2-(4-chlorobenzyl)-4-(4-chlorophenyl)thiazol-5-...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H13Cl2NO2S/c19-13-5-1-11(2-6-13)9-16-21-18(15(24-16)10-17(22)23)12-3-7-14(20)8-4-12/h1-8H,9-10H2,(H,22,23)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309417
PNG
(2-(4-(4-bromophenyl)-2-(naphthalen-2-ylamino)thiaz...)
Show SMILES OC(=O)Cc1sc(Nc2ccc3ccccc3c2)nc1-c1ccc(Br)cc1
Show InChI InChI=1S/C21H15BrN2O2S/c22-16-8-5-14(6-9-16)20-18(12-19(25)26)27-21(24-20)23-17-10-7-13-3-1-2-4-15(13)11-17/h1-11H,12H2,(H,23,24)(H,25,26)
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n/an/a 220n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309412
PNG
(2-(2-(4-methylbenzyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES Cc1ccc(Cc2nc(c(CC(O)=O)s2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H17NO2S/c1-13-7-9-14(10-8-13)11-17-20-19(15-5-3-2-4-6-15)16(23-17)12-18(21)22/h2-10H,11-12H2,1H3,(H,21,22)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309416
PNG
(2-(2-(naphthalen-2-ylamino)-4-(4-phenoxyphenyl)thi...)
Show SMILES OC(=O)Cc1sc(Nc2ccc3ccccc3c2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H20N2O3S/c30-25(31)17-24-26(19-11-14-23(15-12-19)32-22-8-2-1-3-9-22)29-27(33-24)28-21-13-10-18-6-4-5-7-20(18)16-21/h1-16H,17H2,(H,28,29)(H,30,31)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309405
PNG
(2-(4-(4-fluorophenyl)-2-((4'-methoxybiphenyl-2-yl)...)
Show SMILES COc1ccc(cc1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-12-8-16(9-13-20)21-5-3-2-4-18(21)14-23-27-25(22(31-23)15-24(28)29)17-6-10-19(26)11-7-17/h2-13H,14-15H2,1H3,(H,28,29)
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n/an/a 270n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309429
PNG
(2-(4-(biphenyl-4-yl)-2-(2-methoxyphenylamino)thiaz...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H20N2O3S/c1-29-20-10-6-5-9-19(20)25-24-26-23(21(30-24)15-22(27)28)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,15H2,1H3,(H,25,26)(H,27,28)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309411
PNG
(2-(2-(3,4-dimethoxybenzyl)-4-phenylthiazol-5-yl)ac...)
Show SMILES COc1ccc(Cc2nc(c(CC(O)=O)s2)-c2ccccc2)cc1OC
Show InChI InChI=1S/C20H19NO4S/c1-24-15-9-8-13(10-16(15)25-2)11-18-21-20(14-6-4-3-5-7-14)17(26-18)12-19(22)23/h3-10H,11-12H2,1-2H3,(H,22,23)
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n/an/a 330n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309406
PNG
(2-(2-((3'-cyanobiphenyl-2-yl)methyl)-4-(4-fluoroph...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2cccc(c2)C#N)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H17FN2O2S/c26-20-10-8-17(9-11-20)25-22(14-24(29)30)31-23(28-25)13-19-5-1-2-7-21(19)18-6-3-4-16(12-18)15-27/h1-12H,13-14H2,(H,29,30)
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n/an/a 340n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309421
PNG
(2-(4-(4-phenoxyphenyl)-2-(phenylamino)thiazol-5-yl...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H18N2O3S/c26-21(27)15-20-22(25-23(29-20)24-17-7-3-1-4-8-17)16-11-13-19(14-12-16)28-18-9-5-2-6-10-18/h1-14H,15H2,(H,24,25)(H,26,27)
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n/an/a 350n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309451
PNG
(2-(4-(4-bromophenyl)-2-(2-methoxyphenyl)thiazol-5-...)
Show SMILES COc1ccccc1-c1nc(c(CC(O)=O)s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C18H14BrNO3S/c1-23-14-5-3-2-4-13(14)18-20-17(15(24-18)10-16(21)22)11-6-8-12(19)9-7-11/h2-9H,10H2,1H3,(H,21,22)
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n/an/a 350n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309435
PNG
(2-(4-phenyl-2-(phenylamino)thiazol-5-yl)acetic aci...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccccc1
Show InChI InChI=1S/C17H14N2O2S/c20-15(21)11-14-16(12-7-3-1-4-8-12)19-17(22-14)18-13-9-5-2-6-10-13/h1-10H,11H2,(H,18,19)(H,20,21)
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n/an/a 350n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309413
PNG
(2-(2-(4-chlorobenzyl)-4-(4-methoxyphenyl)thiazol-5...)
Show SMILES COc1ccc(cc1)-c1nc(Cc2ccc(Cl)cc2)sc1CC(O)=O
Show InChI InChI=1S/C19H16ClNO3S/c1-24-15-8-4-13(5-9-15)19-16(11-18(22)23)25-17(21-19)10-12-2-6-14(20)7-3-12/h2-9H,10-11H2,1H3,(H,22,23)
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n/an/a 360n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309417
PNG
(2-(4-(4-bromophenyl)-2-(naphthalen-2-ylamino)thiaz...)
Show SMILES OC(=O)Cc1sc(Nc2ccc3ccccc3c2)nc1-c1ccc(Br)cc1
Show InChI InChI=1S/C21H15BrN2O2S/c22-16-8-5-14(6-9-16)20-18(12-19(25)26)27-21(24-20)23-17-10-7-13-3-1-2-4-15(13)11-17/h1-11H,12H2,(H,23,24)(H,25,26)
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n/an/a 370n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309408
PNG
(2-(2-(biphenyl-2-ylmethyl)-4-(4-fluorophenyl)thiaz...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccccc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C24H18FNO2S/c25-19-12-10-17(11-13-19)24-21(15-23(27)28)29-22(26-24)14-18-8-4-5-9-20(18)16-6-2-1-3-7-16/h1-13H,14-15H2,(H,27,28)
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n/an/a 370n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309404
PNG
(2-(4-(4-fluorophenyl)-2-((3'-methoxybiphenyl-2-yl)...)
Show SMILES COc1cccc(c1)-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-20-7-4-6-17(13-20)21-8-3-2-5-18(21)14-23-27-25(22(31-23)15-24(28)29)16-9-11-19(26)12-10-16/h2-13H,14-15H2,1H3,(H,28,29)
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n/an/a 390n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309449
PNG
(2-(4-(4-bromophenyl)-2-(4-methoxyphenyl)thiazol-5-...)
Show SMILES COc1ccc(cc1)-c1nc(c(CC(O)=O)s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C18H14BrNO3S/c1-23-14-8-4-12(5-9-14)18-20-17(15(24-18)10-16(21)22)11-2-6-13(19)7-3-11/h2-9H,10H2,1H3,(H,21,22)
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n/an/a 390n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309430
PNG
(2-(4-(4-chlorophenyl)-2-(2-methoxyphenylamino)thia...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClN2O3S/c1-24-14-5-3-2-4-13(14)20-18-21-17(15(25-18)10-16(22)23)11-6-8-12(19)9-7-11/h2-9H,10H2,1H3,(H,20,21)(H,22,23)
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n/an/a 450n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309448
PNG
(2-(4-(4-bromophenyl)-2-(4-(dimethylamino)phenyl)th...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(c(CC(O)=O)s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C19H17BrN2O2S/c1-22(2)15-9-5-13(6-10-15)19-21-18(16(25-19)11-17(23)24)12-3-7-14(20)8-4-12/h3-10H,11H2,1-2H3,(H,23,24)
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n/an/a 460n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309436
PNG
(2-(4-(4-methoxyphenyl)-2-(4-phenoxyphenyl)thiazol-...)
Show SMILES COc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H19NO4S/c1-28-18-11-7-16(8-12-18)23-21(15-22(26)27)30-24(25-23)17-9-13-20(14-10-17)29-19-5-3-2-4-6-19/h2-14H,15H2,1H3,(H,26,27)
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n/an/a 470n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309436
PNG
(2-(4-(4-methoxyphenyl)-2-(4-phenoxyphenyl)thiazol-...)
Show SMILES COc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H19NO4S/c1-28-18-11-7-16(8-12-18)23-21(15-22(26)27)30-24(25-23)17-9-13-20(14-10-17)29-19-5-3-2-4-6-19/h2-14H,15H2,1H3,(H,26,27)
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n/an/a 470n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309428
PNG
(2-(2-(2-methoxyphenylamino)-4-(4-phenoxyphenyl)thi...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H20N2O4S/c1-29-20-10-6-5-9-19(20)25-24-26-23(21(31-24)15-22(27)28)16-11-13-18(14-12-16)30-17-7-3-2-4-8-17/h2-14H,15H2,1H3,(H,25,26)(H,27,28)
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n/an/a 480n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309269
PNG
(2-(2-(biphenyl-2-ylmethyl)-4-(4-chlorophenyl)thiaz...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H18ClNO2S/c25-19-12-10-17(11-13-19)24-21(15-23(27)28)29-22(26-24)14-18-8-4-5-9-20(18)16-6-2-1-3-7-16/h1-13H,14-15H2,(H,27,28)
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n/an/a 510n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309420
PNG
(2-(2-(4-fluorophenylamino)-4-(4-phenoxyphenyl)thia...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(F)cc2)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17FN2O3S/c24-16-8-10-17(11-9-16)25-23-26-22(20(30-23)14-21(27)28)15-6-12-19(13-7-15)29-18-4-2-1-3-5-18/h1-13H,14H2,(H,25,26)(H,27,28)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309254
PNG
(2-(4-(4-chlorophenyl)-2-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309254
PNG
(2-(4-(4-chlorophenyl)-2-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309423
PNG
(2-(4-(4-chlorophenyl)-2-(p-tolylamino)thiazol-5-yl...)
Show SMILES Cc1ccc(Nc2nc(c(CC(O)=O)s2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H15ClN2O2S/c1-11-2-8-14(9-3-11)20-18-21-17(15(24-18)10-16(22)23)12-4-6-13(19)7-5-12/h2-9H,10H2,1H3,(H,20,21)(H,22,23)
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n/an/a 560n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309398
PNG
(2-(4-(4-chlorophenyl)-2-(naphthalen-2-ylmethyl)thi...)
Show SMILES OC(=O)Cc1sc(Cc2ccc3ccccc3c2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H16ClNO2S/c23-18-9-7-16(8-10-18)22-19(13-21(25)26)27-20(24-22)12-14-5-6-15-3-1-2-4-17(15)11-14/h1-11H,12-13H2,(H,25,26)
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n/an/a 570n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309415
PNG
(2-(2-(4-chlorobenzyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(Cc2ccc(Cl)cc2)nc1-c1ccccc1
Show InChI InChI=1S/C18H14ClNO2S/c19-14-8-6-12(7-9-14)10-16-20-18(13-4-2-1-3-5-13)15(23-16)11-17(21)22/h1-9H,10-11H2,(H,21,22)
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n/an/a 580n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309434
PNG
(2-(4-(4-fluorophenyl)-2-(phenylamino)thiazol-5-yl)...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FN2O2S/c18-12-8-6-11(7-9-12)16-14(10-15(21)22)23-17(20-16)19-13-4-2-1-3-5-13/h1-9H,10H2,(H,19,20)(H,21,22)
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n/an/a 650n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309432
PNG
(2-(4-(biphenyl-4-yl)-2-(phenylamino)thiazol-5-yl)a...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H18N2O2S/c26-21(27)15-20-22(25-23(28-20)24-19-9-5-2-6-10-19)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-14H,15H2,(H,24,25)(H,26,27)
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n/an/a 660n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309425
PNG
(2-(4-(4-chlorophenyl)-2-(4-(trifluoromethyl)phenyl...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(cc2)C(F)(F)F)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClF3N2O2S/c19-12-5-1-10(2-6-12)16-14(9-15(25)26)27-17(24-16)23-13-7-3-11(4-8-13)18(20,21)22/h1-8H,9H2,(H,23,24)(H,25,26)
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n/an/a 700n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309409
PNG
(2-(2-(2-bromobenzyl)-4-(4-fluorophenyl)thiazol-5-y...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2Br)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H13BrFNO2S/c19-14-4-2-1-3-12(14)9-16-21-18(15(24-16)10-17(22)23)11-5-7-13(20)8-6-11/h1-8H,9-10H2,(H,22,23)
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n/an/a 700n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309430
PNG
(2-(4-(4-chlorophenyl)-2-(2-methoxyphenylamino)thia...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClN2O3S/c1-24-14-5-3-2-4-13(14)20-18-21-17(15(25-18)10-16(22)23)11-6-8-12(19)9-7-11/h2-9H,10H2,1H3,(H,20,21)(H,22,23)
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n/an/a 730n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309423
PNG
(2-(4-(4-chlorophenyl)-2-(p-tolylamino)thiazol-5-yl...)
Show SMILES Cc1ccc(Nc2nc(c(CC(O)=O)s2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H15ClN2O2S/c1-11-2-8-14(9-3-11)20-18-21-17(15(24-18)10-16(22)23)12-4-6-13(19)7-5-12/h2-9H,10H2,1H3,(H,20,21)(H,22,23)
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n/an/a 750n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309438
PNG
(2-(2-(4-methoxyphenyl)-4-phenylthiazol-5-yl)acetic...)
Show SMILES COc1ccc(cc1)-c1nc(c(CC(O)=O)s1)-c1ccccc1
Show InChI InChI=1S/C18H15NO3S/c1-22-14-9-7-13(8-10-14)18-19-17(12-5-3-2-4-6-12)15(23-18)11-16(20)21/h2-10H,11H2,1H3,(H,20,21)
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n/an/a 820n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309438
PNG
(2-(2-(4-methoxyphenyl)-4-phenylthiazol-5-yl)acetic...)
Show SMILES COc1ccc(cc1)-c1nc(c(CC(O)=O)s1)-c1ccccc1
Show InChI InChI=1S/C18H15NO3S/c1-22-14-9-7-13(8-10-14)18-19-17(12-5-3-2-4-6-12)15(23-18)11-16(20)21/h2-10H,11H2,1H3,(H,20,21)
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n/an/a 820n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309413
PNG
(2-(2-(4-chlorobenzyl)-4-(4-methoxyphenyl)thiazol-5...)
Show SMILES COc1ccc(cc1)-c1nc(Cc2ccc(Cl)cc2)sc1CC(O)=O
Show InChI InChI=1S/C19H16ClNO3S/c1-24-15-8-4-13(5-9-15)19-16(11-18(22)23)25-17(21-19)10-12-2-6-14(20)7-3-12/h2-9H,10-11H2,1H3,(H,22,23)
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n/an/a 850n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309444
PNG
(2-(4-(4-fluorophenyl)-2-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C17H12FNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)
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n/an/a 860n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309444
PNG
(2-(4-(4-fluorophenyl)-2-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C17H12FNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)
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n/an/a 860n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309445
PNG
(2-(2,4-diphenylthiazol-5-yl)acetic acid | CHEMBL59...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C17H13NO2S/c19-15(20)11-14-16(12-7-3-1-4-8-12)18-17(21-14)13-9-5-2-6-10-13/h1-10H,11H2,(H,19,20)
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n/an/a 870n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309445
PNG
(2-(2,4-diphenylthiazol-5-yl)acetic acid | CHEMBL59...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C17H13NO2S/c19-15(20)11-14-16(12-7-3-1-4-8-12)18-17(21-14)13-9-5-2-6-10-13/h1-10H,11H2,(H,19,20)
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n/an/a 870n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309422
PNG
(2-(2-(4-methoxyphenylamino)-4-phenylthiazol-5-yl)a...)
Show SMILES COc1ccc(Nc2nc(c(CC(O)=O)s2)-c2ccccc2)cc1
Show InChI InChI=1S/C18H16N2O3S/c1-23-14-9-7-13(8-10-14)19-18-20-17(12-5-3-2-4-6-12)15(24-18)11-16(21)22/h2-10H,11H2,1H3,(H,19,20)(H,21,22)
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n/an/a 940n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309426
PNG
(2-(4-(biphenyl-4-yl)-2-(4-chlorophenylamino)thiazo...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(Cl)cc2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H17ClN2O2S/c24-18-10-12-19(13-11-18)25-23-26-22(20(29-23)14-21(27)28)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a 940n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309427
PNG
(2-(2-(4-chlorophenylamino)-4-(4-fluorophenyl)thiaz...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(Cl)cc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12ClFN2O2S/c18-11-3-7-13(8-4-11)20-17-21-16(14(24-17)9-15(22)23)10-1-5-12(19)6-2-10/h1-8H,9H2,(H,20,21)(H,22,23)
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n/an/a 960n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309439
PNG
(2-(2-(4-chlorophenyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H12ClNO2S/c18-13-8-6-12(7-9-13)17-19-16(11-4-2-1-3-5-11)14(22-17)10-15(20)21/h1-9H,10H2,(H,20,21)
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n/an/a 990n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309439
PNG
(2-(2-(4-chlorophenyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H12ClNO2S/c18-13-8-6-12(7-9-13)17-19-16(11-4-2-1-3-5-11)14(22-17)10-15(20)21/h1-9H,10H2,(H,20,21)
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n/an/a 990n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309446
PNG
(2-(2-(4-chlorophenyl)-4-(2,4-dimethylphenyl)thiazo...)
Show SMILES Cc1ccc(-c2nc(sc2CC(O)=O)-c2ccc(Cl)cc2)c(C)c1
Show InChI InChI=1S/C19H16ClNO2S/c1-11-3-8-15(12(2)9-11)18-16(10-17(22)23)24-19(21-18)13-4-6-14(20)7-5-13/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 990n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309425
PNG
(2-(4-(4-chlorophenyl)-2-(4-(trifluoromethyl)phenyl...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(cc2)C(F)(F)F)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClF3N2O2S/c19-12-5-1-10(2-6-12)16-14(9-15(25)26)27-17(24-16)23-13-7-3-11(4-8-13)18(20,21)22/h1-8H,9H2,(H,23,24)(H,25,26)
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n/an/a 1.10E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309424
PNG
(2-(4-(4-chlorophenyl)-2-(4-isopropylphenylamino)th...)
Show SMILES CC(C)c1ccc(Nc2nc(c(CC(O)=O)s2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H19ClN2O2S/c1-12(2)13-5-9-16(10-6-13)22-20-23-19(17(26-20)11-18(24)25)14-3-7-15(21)8-4-14/h3-10,12H,11H2,1-2H3,(H,22,23)(H,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309432
PNG
(2-(4-(biphenyl-4-yl)-2-(phenylamino)thiazol-5-yl)a...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H18N2O2S/c26-21(27)15-20-22(25-23(28-20)24-19-9-5-2-6-10-19)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-14H,15H2,(H,24,25)(H,26,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309434
PNG
(2-(4-(4-fluorophenyl)-2-(phenylamino)thiazol-5-yl)...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FN2O2S/c18-12-8-6-11(7-9-12)16-14(10-15(21)22)23-17(20-16)19-13-4-2-1-3-5-13/h1-9H,10H2,(H,19,20)(H,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309259
PNG
(2-(4-(4-chlorophenyl)-2-(phenylamino)thiazol-5-yl)...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13ClN2O2S/c18-12-8-6-11(7-9-12)16-14(10-15(21)22)23-17(20-16)19-13-4-2-1-3-5-13/h1-9H,10H2,(H,19,20)(H,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309442
PNG
(2-(4-(4-ethylphenyl)-2-phenylthiazol-5-yl)acetic a...)
Show SMILES CCc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C19H17NO2S/c1-2-13-8-10-14(11-9-13)18-16(12-17(21)22)23-19(20-18)15-6-4-3-5-7-15/h3-11H,2,12H2,1H3,(H,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309442
PNG
(2-(4-(4-ethylphenyl)-2-phenylthiazol-5-yl)acetic a...)
Show SMILES CCc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C19H17NO2S/c1-2-13-8-10-14(11-9-13)18-16(12-17(21)22)23-19(20-18)15-6-4-3-5-7-15/h3-11H,2,12H2,1H3,(H,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309452
PNG
(2-(4-(4-ethylphenyl)-2-(2-methoxyphenyl)thiazol-5-...)
Show SMILES CCc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccccc1OC
Show InChI InChI=1S/C20H19NO3S/c1-3-13-8-10-14(11-9-13)19-17(12-18(22)23)25-20(21-19)15-6-4-5-7-16(15)24-2/h4-11H,3,12H2,1-2H3,(H,22,23)
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n/an/a 1.40E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309422
PNG
(2-(2-(4-methoxyphenylamino)-4-phenylthiazol-5-yl)a...)
Show SMILES COc1ccc(Nc2nc(c(CC(O)=O)s2)-c2ccccc2)cc1
Show InChI InChI=1S/C18H16N2O3S/c1-23-14-9-7-13(8-10-14)19-18-20-17(12-5-3-2-4-6-12)15(24-18)11-16(21)22/h2-10H,11H2,1H3,(H,19,20)(H,21,22)
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n/an/a 1.50E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309401
PNG
(2-(2-(2-(benzo[d][1,3]dioxol-5-yl)benzyl)-4-(4-flu...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2ccc3OCOc3c2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H18FNO4S/c26-18-8-5-15(6-9-18)25-22(13-24(28)29)32-23(27-25)12-16-3-1-2-4-19(16)17-7-10-20-21(11-17)31-14-30-20/h1-11H,12-14H2,(H,28,29)
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n/an/a 1.50E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309440
PNG
(2-(2-(4-fluorophenyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H12FNO2S/c18-13-8-6-12(7-9-13)17-19-16(11-4-2-1-3-5-11)14(22-17)10-15(20)21/h1-9H,10H2,(H,20,21)
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n/an/a 1.50E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309435
PNG
(2-(4-phenyl-2-(phenylamino)thiazol-5-yl)acetic aci...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2)nc1-c1ccccc1
Show InChI InChI=1S/C17H14N2O2S/c20-15(21)11-14-16(12-7-3-1-4-8-12)19-17(22-14)18-13-9-5-2-6-10-13/h1-10H,11H2,(H,18,19)(H,20,21)
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n/an/a 1.50E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309440
PNG
(2-(2-(4-fluorophenyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(nc1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H12FNO2S/c18-13-8-6-12(7-9-13)17-19-16(11-4-2-1-3-5-11)14(22-17)10-15(20)21/h1-9H,10H2,(H,20,21)
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n/an/a 1.50E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309431
PNG
(2-(4-(4-fluorophenyl)-2-(2-methoxyphenylamino)thia...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN2O3S/c1-24-14-5-3-2-4-13(14)20-18-21-17(15(25-18)10-16(22)23)11-6-8-12(19)9-7-11/h2-9H,10H2,1H3,(H,20,21)(H,22,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309412
PNG
(2-(2-(4-methylbenzyl)-4-phenylthiazol-5-yl)acetic ...)
Show SMILES Cc1ccc(Cc2nc(c(CC(O)=O)s2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H17NO2S/c1-13-7-9-14(10-8-13)11-17-20-19(15-5-3-2-4-6-15)16(23-17)12-18(21)22/h2-10H,11-12H2,1H3,(H,21,22)
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n/an/a 1.80E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309429
PNG
(2-(4-(biphenyl-4-yl)-2-(2-methoxyphenylamino)thiaz...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H20N2O3S/c1-29-20-10-6-5-9-19(20)25-24-26-23(21(30-24)15-22(27)28)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,15H2,1H3,(H,25,26)(H,27,28)
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n/an/a 1.90E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309427
PNG
(2-(2-(4-chlorophenylamino)-4-(4-fluorophenyl)thiaz...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(Cl)cc2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H12ClFN2O2S/c18-11-3-7-13(8-4-11)20-17-21-16(14(24-17)9-15(22)23)10-1-5-12(19)6-2-10/h1-8H,9H2,(H,20,21)(H,22,23)
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n/an/a 1.90E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309433
PNG
(2-(4-(4-methoxyphenyl)-2-(phenylamino)thiazol-5-yl...)
Show SMILES COc1ccc(cc1)-c1nc(Nc2ccccc2)sc1CC(O)=O
Show InChI InChI=1S/C18H16N2O3S/c1-23-14-9-7-12(8-10-14)17-15(11-16(21)22)24-18(20-17)19-13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,19,20)(H,21,22)
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n/an/a 1.90E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309431
PNG
(2-(4-(4-fluorophenyl)-2-(2-methoxyphenylamino)thia...)
Show SMILES COc1ccccc1Nc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN2O3S/c1-24-14-5-3-2-4-13(14)20-18-21-17(15(25-18)10-16(22)23)11-6-8-12(19)9-7-11/h2-9H,10H2,1H3,(H,20,21)(H,22,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309433
PNG
(2-(4-(4-methoxyphenyl)-2-(phenylamino)thiazol-5-yl...)
Show SMILES COc1ccc(cc1)-c1nc(Nc2ccccc2)sc1CC(O)=O
Show InChI InChI=1S/C18H16N2O3S/c1-23-14-9-7-12(8-10-14)17-15(11-16(21)22)24-18(20-17)19-13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,19,20)(H,21,22)
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n/an/a 2.40E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309411
PNG
(2-(2-(3,4-dimethoxybenzyl)-4-phenylthiazol-5-yl)ac...)
Show SMILES COc1ccc(Cc2nc(c(CC(O)=O)s2)-c2ccccc2)cc1OC
Show InChI InChI=1S/C20H19NO4S/c1-24-15-9-8-13(10-16(15)25-2)11-18-21-20(14-6-4-3-5-7-14)17(26-18)12-19(22)23/h3-10H,11-12H2,1-2H3,(H,22,23)
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n/an/a 3.80E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309426
PNG
(2-(4-(biphenyl-4-yl)-2-(4-chlorophenylamino)thiazo...)
Show SMILES OC(=O)Cc1sc(Nc2ccc(Cl)cc2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H17ClN2O2S/c24-18-10-12-19(13-11-18)25-23-26-22(20(29-23)14-21(27)28)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a 3.80E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309450
PNG
(2-(2,4-bis(4-methoxyphenyl)thiazol-5-yl)acetic aci...)
Show SMILES COc1ccc(cc1)-c1nc(c(CC(O)=O)s1)-c1ccc(OC)cc1
Show InChI InChI=1S/C19H17NO4S/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-19(20-18)13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22)
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n/an/a 4.10E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309255
PNG
(2-(2-benzyl-4-(4-chlorophenyl)thiazol-5-yl)acetic ...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14ClNO2S/c19-14-8-6-13(7-9-14)18-15(11-17(21)22)23-16(20-18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,21,22)
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n/an/a 4.10E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309443
PNG
(2-(4-(4-methoxyphenyl)-2-phenylthiazol-5-yl)acetic...)
Show SMILES COc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C18H15NO3S/c1-22-14-9-7-12(8-10-14)17-15(11-16(20)21)23-18(19-17)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,20,21)
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n/an/a 7.00E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309443
PNG
(2-(4-(4-methoxyphenyl)-2-phenylthiazol-5-yl)acetic...)
Show SMILES COc1ccc(cc1)-c1nc(sc1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C18H15NO3S/c1-22-14-9-7-12(8-10-14)17-15(11-16(20)21)23-18(19-17)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,20,21)
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n/an/a 7.00E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309424
PNG
(2-(4-(4-chlorophenyl)-2-(4-isopropylphenylamino)th...)
Show SMILES CC(C)c1ccc(Nc2nc(c(CC(O)=O)s2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H19ClN2O2S/c1-12(2)13-5-9-16(10-6-13)22-20-23-19(17(26-20)11-18(24)25)14-3-7-15(21)8-4-14/h3-10,12H,11H2,1-2H3,(H,22,23)(H,24,25)
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n/an/a 1.60E+4n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309419
PNG
(2-(2-(2-fluorophenylamino)-4-(4-phenoxyphenyl)thia...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2F)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17FN2O3S/c24-18-8-4-5-9-19(18)25-23-26-22(20(30-23)14-21(27)28)15-10-12-17(13-11-15)29-16-6-2-1-3-7-16/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309402
PNG
(2-(4-(4-fluorophenyl)-2-((3'-(trifluoromethoxy)bip...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2cccc(OC(F)(F)F)c2)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H17F4NO3S/c26-18-10-8-15(9-11-18)24-21(14-23(31)32)34-22(30-24)13-17-4-1-2-7-20(17)16-5-3-6-19(12-16)33-25(27,28)29/h1-12H,13-14H2,(H,31,32)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309406
PNG
(2-(2-((3'-cyanobiphenyl-2-yl)methyl)-4-(4-fluoroph...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2-c2cccc(c2)C#N)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H17FN2O2S/c26-20-10-8-17(9-11-20)25-22(14-24(29)30)31-23(28-25)13-19-5-1-2-7-21(19)18-6-3-4-16(12-18)15-27/h1-12H,13-14H2,(H,29,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309403
PNG
(2-(4-(4-fluorophenyl)-2-((2'-methoxybiphenyl-2-yl)...)
Show SMILES COc1ccccc1-c1ccccc1Cc1nc(c(CC(O)=O)s1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FNO3S/c1-30-21-9-5-4-8-20(21)19-7-3-2-6-17(19)14-23-27-25(22(31-23)15-24(28)29)16-10-12-18(26)13-11-16/h2-13H,14-15H2,1H3,(H,28,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309409
PNG
(2-(2-(2-bromobenzyl)-4-(4-fluorophenyl)thiazol-5-y...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2Br)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H13BrFNO2S/c19-14-4-2-1-3-12(14)9-16-21-18(15(24-16)10-17(22)23)11-5-7-13(20)8-6-11/h1-8H,9-10H2,(H,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309400
PNG
(2-(4-(4-chlorophenyl)-2-(2-phenoxybenzyl)thiazol-5...)
Show SMILES OC(=O)Cc1sc(Cc2ccccc2Oc2ccccc2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H18ClNO3S/c25-18-12-10-16(11-13-18)24-21(15-23(27)28)30-22(26-24)14-17-6-4-5-9-20(17)29-19-7-2-1-3-8-19/h1-13H,14-15H2,(H,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))
BDBM50309418
PNG
(2-(2-(2-chlorophenylamino)-4-(4-phenoxyphenyl)thia...)
Show SMILES OC(=O)Cc1sc(Nc2ccccc2Cl)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H17ClN2O3S/c24-18-8-4-5-9-19(18)25-23-26-22(20(30-23)14-21(27)28)15-10-12-17(13-11-15)29-16-6-2-1-3-7-16/h1-13H,14H2,(H,25,26)(H,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed as inhibition of beta arrestin translocation by bioluminescence reso...


Bioorg Med Chem Lett 20: 1177-80 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.008
BindingDB Entry DOI: 10.7270/Q25T3KMP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%