Found 32 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cathepsin K
(Homo sapiens (Human)) | BDBM50313524
(3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313531
(2-(3-isopropylphenyl)-3,5-dioxo-4-(3-(piperidin-1-...)Show SMILES CC(C)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C21H27N5O2/c1-16(2)17-8-6-9-18(14-17)26-21(28)25(20(27)19(15-22)23-26)13-7-12-24-10-4-3-5-11-24/h6,8-9,14,16H,3-5,7,10-13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313514
(2-cycloheptyl-3,5-dioxo-4-propyl-2,3,4,5-tetrahydr...)Show InChI InChI=1S/C14H20N4O2/c1-2-9-17-13(19)12(10-15)16-18(14(17)20)11-7-5-3-4-6-8-11/h11H,2-9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313507
(2-(3-isopropylphenyl)-3,5-dioxo-4-propyl-2,3,4,5-t...)Show InChI InChI=1S/C16H18N4O2/c1-4-8-19-15(21)14(10-17)18-20(16(19)22)13-7-5-6-12(9-13)11(2)3/h5-7,9,11H,4,8H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313523
(4-(3-(dimethylamino)propyl)-3,5-dioxo-2-(3-(triflu...)Show SMILES CN(C)CCCn1c(=O)c(nn(-c2cccc(c2)C(F)(F)F)c1=O)C#N Show InChI InChI=1S/C16H16F3N5O2/c1-22(2)7-4-8-23-14(25)13(10-20)21-24(15(23)26)12-6-3-5-11(9-12)16(17,18)19/h3,5-6,9H,4,7-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313529
(2-cycloheptyl-3,5-dioxo-4-(3-(piperidin-1-yl)propy...)Show InChI InChI=1S/C19H29N5O2/c20-15-17-18(25)23(14-8-13-22-11-6-3-7-12-22)19(26)24(21-17)16-9-4-1-2-5-10-16/h16H,1-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313528
(2-cycloheptyl-4-(3-(dimethylamino)propyl)-3,5-diox...)Show InChI InChI=1S/C16H25N5O2/c1-19(2)10-7-11-20-15(22)14(12-17)18-21(16(20)23)13-8-5-3-4-6-9-13/h13H,3-11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313527
(4-(3-morpholinopropyl)-3,5-dioxo-2-(3-(trifluorome...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCOCC2)c1=O Show InChI InChI=1S/C18H18F3N5O3/c19-18(20,21)13-3-1-4-14(11-13)26-17(28)25(16(27)15(12-22)23-26)6-2-5-24-7-9-29-10-8-24/h1,3-4,11H,2,5-10H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313525
(3,5-dioxo-4-(2-(piperidin-1-yl)ethyl)-2-(3-(triflu...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCN2CCCCC2)c1=O Show InChI InChI=1S/C18H18F3N5O2/c19-18(20,21)13-5-4-6-14(11-13)26-17(28)25(16(27)15(12-22)23-26)10-9-24-7-2-1-3-8-24/h4-6,11H,1-3,7-10H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313513
(2-cyclohexyl-3,5-dioxo-4-propyl-2,3,4,5-tetrahydro...)Show InChI InChI=1S/C13H18N4O2/c1-2-8-16-12(18)11(9-14)15-17(13(16)19)10-6-4-3-5-7-10/h10H,2-8H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 197 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313508
(2-(3-tert-butylphenyl)-3,5-dioxo-4-propyl-2,3,4,5-...)Show SMILES CCCn1c(=O)c(nn(-c2cccc(c2)C(C)(C)C)c1=O)C#N Show InChI InChI=1S/C17H20N4O2/c1-5-9-20-15(22)14(11-18)19-21(16(20)23)13-8-6-7-12(10-13)17(2,3)4/h6-8,10H,5,9H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 288 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313530
(2-cycloheptyl-4-(3-morpholinopropyl)-3,5-dioxo-2,3...)Show InChI InChI=1S/C18H27N5O3/c19-14-16-17(24)22(9-5-8-21-10-12-26-13-11-21)18(25)23(20-16)15-6-3-1-2-4-7-15/h15H,1-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313526
(4-(2-(dimethylamino)ethyl)-3,5-dioxo-2-(3-(trifluo...)Show SMILES CN(C)CCn1c(=O)c(nn(-c2cccc(c2)C(F)(F)F)c1=O)C#N Show InChI InChI=1S/C15H14F3N5O2/c1-21(2)6-7-22-13(24)12(9-19)20-23(14(22)25)11-5-3-4-10(8-11)15(16,17)18/h3-5,8H,6-7H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313512
(2-cyclopentyl-3,5-dioxo-4-propyl-2,3,4,5-tetrahydr...)Show InChI InChI=1S/C12H16N4O2/c1-2-7-15-11(17)10(8-13)14-16(12(15)18)9-5-3-4-6-9/h9H,2-7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313521
(4-benzyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C18H11F3N4O2/c19-18(20,21)13-7-4-8-14(9-13)25-17(27)24(16(26)15(10-22)23-25)11-12-5-2-1-3-6-12/h1-9H,11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313515
(2-(cyclohexylmethyl)-3,5-dioxo-4-propyl-2,3,4,5-te...)Show InChI InChI=1S/C14H20N4O2/c1-2-8-17-13(19)12(9-15)16-18(14(17)20)10-11-6-4-3-5-7-11/h11H,2-8,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313519
(4-cyclopentyl-3,5-dioxo-2-(3-(trifluoromethyl)phen...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(C2CCCC2)c1=O Show InChI InChI=1S/C16H13F3N4O2/c17-16(18,19)10-4-3-7-12(8-10)23-15(25)22(11-5-1-2-6-11)14(24)13(9-20)21-23/h3-4,7-8,11H,1-2,5-6H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313503
(3,5-dioxo-4-propyl-2-(3-(trifluoromethyl)phenyl)-2...)Show SMILES CCCn1c(=O)c(nn(-c2cccc(c2)C(F)(F)F)c1=O)C#N Show InChI InChI=1S/C14H11F3N4O2/c1-2-6-20-12(22)11(8-18)19-21(13(20)23)10-5-3-4-9(7-10)14(15,16)17/h3-5,7H,2,6H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313517
(4-ethyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,...)Show InChI InChI=1S/C13H9F3N4O2/c1-2-19-11(21)10(7-17)18-20(12(19)22)9-5-3-4-8(6-9)13(14,15)16/h3-6H,2H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313506
(3,5-dioxo-4-propyl-2-m-tolyl-2,3,4,5-tetrahydro-1,...)Show InChI InChI=1S/C14H14N4O2/c1-3-7-17-13(19)12(9-15)16-18(14(17)20)11-6-4-5-10(2)8-11/h4-6,8H,3,7H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313522
(3,5-dioxo-4-phenethyl-2-(3-(trifluoromethyl)phenyl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCc2ccccc2)c1=O Show InChI InChI=1S/C19H13F3N4O2/c20-19(21,22)14-7-4-8-15(11-14)26-18(28)25(17(27)16(12-23)24-26)10-9-13-5-2-1-3-6-13/h1-8,11H,9-10H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313518
(4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2...)Show InChI InChI=1S/C12H7F3N4O2/c1-18-10(20)9(6-16)17-19(11(18)21)8-4-2-3-7(5-8)12(13,14)15/h2-5H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313516
(4-butyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,...)Show SMILES CCCCn1c(=O)c(nn(-c2cccc(c2)C(F)(F)F)c1=O)C#N Show InChI InChI=1S/C15H13F3N4O2/c1-2-3-7-21-13(23)12(9-19)20-22(14(21)24)11-6-4-5-10(8-11)15(16,17)18/h4-6,8H,2-3,7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313509
(2-(biphenyl-3-yl)-3,5-dioxo-4-propyl-2,3,4,5-tetra...)Show SMILES CCCn1c(=O)c(nn(-c2cccc(c2)-c2ccccc2)c1=O)C#N Show InChI InChI=1S/C19H16N4O2/c1-2-11-22-18(24)17(13-20)21-23(19(22)25)16-10-6-9-15(12-16)14-7-4-3-5-8-14/h3-10,12H,2,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50313524
(3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of cathepsin L |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50313524
(3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of cathepsin B |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313504
(3,5-dioxo-4-propyl-2-(4-(trifluoromethyl)phenyl)-2...)Show SMILES CCCn1c(=O)c(nn(-c2ccc(cc2)C(F)(F)F)c1=O)C#N Show InChI InChI=1S/C14H11F3N4O2/c1-2-7-20-12(22)11(8-18)19-21(13(20)23)10-5-3-9(4-6-10)14(15,16)17/h3-6H,2,7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313505
(3,5-dioxo-2-phenyl-4-propyl-2,3,4,5-tetrahydro-1,2...)Show InChI InChI=1S/C13H12N4O2/c1-2-8-16-12(18)11(9-14)15-17(13(16)19)10-6-4-3-5-7-10/h3-7H,2,8H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313510
(2-(3-methoxyphenyl)-3,5-dioxo-4-propyl-2,3,4,5-tet...)Show InChI InChI=1S/C14H14N4O3/c1-3-7-17-13(19)12(9-15)16-18(14(17)20)10-5-4-6-11(8-10)21-2/h4-6,8H,3,7H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313511
(2-(3-(hydroxymethyl)phenyl)-3,5-dioxo-4-propyl-2,3...)Show InChI InChI=1S/C14H14N4O3/c1-2-6-17-13(20)12(8-15)16-18(14(17)21)11-5-3-4-10(7-11)9-19/h3-5,7,19H,2,6,9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin S
(Homo sapiens (Human)) | BDBM50313524
(3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)14-6-4-7-15(12-14)27-18(29)26(17(28)16(13-23)24-27)11-5-10-25-8-2-1-3-9-25/h4,6-7,12H,1-3,5,8-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of cathepsin S |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50313520
(3,5-dioxo-4-phenyl-2-(3-(trifluoromethyl)phenyl)-2...)Show SMILES FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C17H9F3N4O2/c18-17(19,20)11-5-4-8-13(9-11)24-16(26)23(12-6-2-1-3-7-12)15(25)14(10-21)22-24/h1-9H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 20: 1488-90 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.116
BindingDB Entry DOI: 10.7270/Q2RN380F |
More data for this
Ligand-Target Pair | |
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