Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50313506 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_617674 (CHEMBL1101470) |
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IC50 | 3500±n/a nM |
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Citation | Rankovic, Z; Cai, J; Fradera, X; Dempster, M; Mistry, A; Mitchell, A; Long, C; Hamilton, E; King, A; Boucharens, S; Jamieson, C; Gillespie, J; Cumming, I; Uitdehaag, J; van Zeeland, M Dioxo-triazines as a novel series of cathepsin K inhibitors. Bioorg Med Chem Lett20:1488-90 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50313506 |
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n/a |
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Name | BDBM50313506 |
Synonyms: | 3,5-dioxo-4-propyl-2-m-tolyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | CHEMBL1078869 |
Type | Small organic molecule |
Emp. Form. | C14H14N4O2 |
Mol. Mass. | 270.2866 |
SMILES | CCCn1c(=O)c(nn(-c2cccc(C)c2)c1=O)C#N |
Structure |
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