Affinity Data by PubMed id=20206015

PubMed code 20206015

Found 22 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14777 ((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316422 ((5R,11aR)-5-(2-Bromophenyl)-2-ethyl-5,6,11,11a-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316440 ((6R,12aS)-2-Benzyl-6-(2-bromophenyl)-2,3,6,7,12,12...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316438 ((6R,12aS)-6-(2-Bromophenyl)-2-butyl-2,3,6,7,12,12a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316436 ((6R,12aS)-6-(2-Bromophenyl)-2-ethyl-2,3,6,7,12,12a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316432 ((6R,12aS)-6-(2-Bromophenyl)-2-methyl-2,3,6,7,12,12...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316429 ((6R,12aR)-6-(2-Bromophenyl)-2-methyl-2,3,6,7,12,12...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316437 ((6R,12aR)-6-(2-Bromophenyl)-2-butyl-2,3,6,7,12,12a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316422 ((5R,11aR)-5-(2-Bromophenyl)-2-ethyl-5,6,11,11a-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316433 ((6R,12aR)-6-(2-Bromophenyl)-2-ethyl-2,3,6,7,12,12a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316423 ((5S,11aR)-5-(2-Bromophenyl)-2-ethyl-5,6,11,11a-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316431 ((6S,12aS)-6-(2-Bromophenyl)-2-methyl-2,3,6,7,12,12...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316421 ((1R,3S)Methyl 1-(2-bromophenyl)-2,3,4,9-tetrahydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316439 ((6R,12aR)-2-Benzyl-6-(2-bromophenyl)-2,3,6,7,12,12...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316423 ((5S,11aR)-5-(2-Bromophenyl)-2-ethyl-5,6,11,11a-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316420 ((1R,3R)Methyl 1-(2-bromophenyl)-2,3,4,9-tetrahydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316427 ((5R-11aS)-5-(2-Bromophenyl)-2-ethyl-1-oxo-5,6,11,1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316428 (CHEMBL1097216 \| Methyl(1R,3R)-1-(2-bromophenyl)-2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316435 ((6S,12aS)-6-(2-Bromophenyl)-2-ethyl-2,3,6,7,12,12a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316434 ((6S,12aR)-6-(2-Bromophenyl)-2-ethyl-2,3,6,7,12,12a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316426 ((5S,11aR)-5-(2-Bromophenyl)-2-ethyl-1-oxo-5,6,11,1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316430 ((6S,12aR)-6-(2-Bromophenyl)-2-methyl-2,3,6,7,12,12...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%