Affinity Data by PubMed id=20809633

PubMed code 20809633

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50327688 (3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[4,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-MPEP from mGluR5 in rat cortical membranes				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50327695 (3-Fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-MPEP from mGluR5 in rat cortical membranes				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327695 (3-Fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327688 (3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[4,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327689 (3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[5,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327694 (3-(2-(Pyridin-2-yl)-7,8-dihydro-4H-oxazolo[4,5-c]a...) Show SMILES N#Cc1cccc(c1)N1CCCc2oc(nc2C1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327686 (3-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyrid...) Show SMILES N#Cc1cccc(c1)N1CCc2oc(nc2C1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327683 (2-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyrid...) Show SMILES N#Cc1cccnc1N1CCc2oc(nc2C1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327693 (3-(2-(pyridin-2-yl)-3aH-pyrrolo[3,4-d]oxazol-5(4H,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327691 (3-fluoro-5-(2-(pyridin-2-yl)-5,6-dihydroimidazo[1,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327687 (3-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyrid...) Show SMILES N#Cc1cccc(c1)N1CCc2nc(oc2C1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327685 (5-Phenyl-2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazol...) Show SMILES C1Cc2oc(nc2CN1c1ccccc1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327692 (3-Fluoro-5-(2-(pyridin-2-yl)-5,6-dihydro-[1,2,4]tr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	346	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327684 (2-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyrid...) Show SMILES N#Cc1cccnc1N1CCc2nc(oc2C1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327682 (2-(2-Phenyl-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)...) Show SMILES N#Cc1cccnc1N1CCc2oc(nc2C1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50327690 (3-(2-(Pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[5,4-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response				J Med Chem 53: 7107-18 (2010) Article DOI: 10.1021/jm100736h BindingDB Entry DOI: 10.7270/Q20G3KCJ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%