Affinity Data by PubMed id=21144757

PubMed code 21144757

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 5 (Homo sapiens (Human))	BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin A				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM76780 (6-(1-methoxybutan-2-yloxy)-N-(phenylmethyl)-1-prop...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM81208 (6-methoxy-N-(phenylmethyl)-1-propan-2-yl-4-benzimi...) Show SMILES COc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334335 (2-(4-(benzylamino)-1-isopropyl-1H-benzo[d]imidazol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334341 (CHEMBL1277150 \| N-benzyl-6-butoxy-1-isopropyl-1H-b...) Show SMILES CCCCOc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334334 (CHEMBL1277149 \| N-benzyl-1-isopropyl-6-propoxy-1H-...) Show SMILES CCCOc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334339 (CHEMBL1358008 \| N-Benzyl-6-(1-(dimethylamino)butan...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM81206 (6-ethoxy-N-(phenylmethyl)-1-propan-2-yl-4-benzimid...) Show SMILES CCOc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334338 (CHEMBL1277151 \| N-Benzyl-1-isopropyl-6-(2-methoxye...) Show SMILES COCCOc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334337 (1-(4-(benzylamino)-1-isopropyl-1H-benzo[d]imidazol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334340 (CHEMBL1643063 \| N-Benzyl-1-isopropyl-6-(piperidin-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50334336 (2-(4-(Benzylamino)-1-isopropyl-1H-benzo[d]imidazol...) Show SMILES CC(C)n1cnc2c(NCc3ccccc3)cc(OCCO)cc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM76779 (6-[(1-methyl-4-piperidinyl)methoxy]-N-(phenylmethy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting				Bioorg Med Chem 19: 359-73 (2011) Article DOI: 10.1016/j.bmc.2010.11.022 BindingDB Entry DOI: 10.7270/Q21G0MJC
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%