Found 22 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50236983
(2-Hydroxy-cyclohepta-2,4,6-trienone | 2-hydroxycyc...)Show InChI InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase after 10 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335802
(4-Fluoro-N-(8-hydroxyquinolin-7-yl)benzenesulfonam...)Show InChI InChI=1S/C15H11FN2O3S/c16-11-4-6-12(7-5-11)22(20,21)18-13-8-3-10-2-1-9-17-14(10)15(13)19/h1-9,18-19H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50335803
(3-hydroxy-2-methyl-4H-pyran-4-thione | CHEMBL16506...)Show InChI InChI=1S/C6H6O2S/c1-4-6(7)5(9)2-3-8-4/h2-3,7H,1H3 | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase after 10 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335813
(CHEMBL1650642 | N-(8-Hydroxyquinolin-7-yl)-[1,1-bi...)Show SMILES Oc1c(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)ccc2cccnc12 Show InChI InChI=1S/C21H16N2O3S/c24-21-19(13-10-17-7-4-14-22-20(17)21)23-27(25,26)18-11-8-16(9-12-18)15-5-2-1-3-6-15/h1-14,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335814
(CHEMBL1650643 | N-(8-Hydroxyquinolin-7-yl)thiophen...)Show InChI InChI=1S/C13H10N2O3S2/c16-13-10(6-5-9-3-1-7-14-12(9)13)15-20(17,18)11-4-2-8-19-11/h1-8,15-16H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335807
(CHEMBL1650640 | N-(8-Hydroxyquinolin-7-yl)benzenes...)Show InChI InChI=1S/C15H12N2O3S/c18-15-13(9-8-11-5-4-10-16-14(11)15)17-21(19,20)12-6-2-1-3-7-12/h1-10,17-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335805
(4-Fluoro-N-(8-hydroxyquinolin-5-yl)benzenesulfonam...)Show InChI InChI=1S/C15H11FN2O3S/c16-10-3-5-11(6-4-10)22(20,21)18-13-7-8-14(19)15-12(13)2-1-9-17-15/h1-9,18-19H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335812
(CHEMBL1650639 | N-(8-Hydroxyquinolin-5-yl)thiophen...)Show InChI InChI=1S/C13H10N2O3S2/c16-11-6-5-10(9-3-1-7-14-13(9)11)15-20(17,18)12-4-2-8-19-12/h1-8,15-16H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335804
(CHEMBL1650636 | N-(8-Hydroxyquinolin-5-yl)benzenes...)Show InChI InChI=1S/C15H12N2O3S/c18-14-9-8-13(12-7-4-10-16-15(12)14)17-21(19,20)11-5-2-1-3-6-11/h1-10,17-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335801
(CHEMBL1650638 | N-(8-Hydroxyquinolin-5-yl)-[1,1'-b...)Show SMILES Oc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)c2cccnc12 Show InChI InChI=1S/C21H16N2O3S/c24-20-13-12-19(18-7-4-14-22-21(18)20)23-27(25,26)17-10-8-16(9-11-17)15-5-2-1-3-6-15/h1-14,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50335803
(3-hydroxy-2-methyl-4H-pyran-4-thione | CHEMBL16506...)Show InChI InChI=1S/C6H6O2S/c1-4-6(7)5(9)2-3-8-4/h2-3,7H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-lipoxygenase after 10 mins by fluorescence assay |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50335808
(2,5-Dihydroxybenzoate, VI | 2,5-dihydroxybenzoic a...)Show InChI InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 5-lipoxygenase after 10 mins by fluorescence assay |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335806
(3-hydroxy-4H-pyran-4-thione | CHEMBL1649594)Show InChI InChI=1S/C5H4O2S/c6-4-3-7-2-1-5(4)8/h1-3,6H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 7.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM26193
(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)Show InChI InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase after 10 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335810
(2-thiouracil | 4-mercaptopyrimidin-2-ol | CHEMBL16...)Show InChI InChI=1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.21E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM32203
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50236983
(2-Hydroxy-cyclohepta-2,4,6-trienone | 2-hydroxycyc...)Show InChI InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.46E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50335809
(6-hydroxypicolinic acid | CHEMBL1650602)Show InChI InChI=1S/C6H5NO3/c8-5-3-1-2-4(7-5)6(9)10/h1-3H,(H,7,8)(H,9,10) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.59E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase after 10 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Lethal factor
(Bacillus anthracis) | BDBM50335806
(3-hydroxy-4H-pyran-4-thione | CHEMBL1649594)Show InChI InChI=1S/C5H4O2S/c6-4-3-7-2-1-5(4)8/h1-3,6H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.04E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of recombinant anthrax lethal factor after 30 mins by fluorescence assay |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50335811
(3-amino-2-hydroxybenzoic acid | CHEMBL1650630)Show InChI InChI=1S/C7H7NO3/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,9H,8H2,(H,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.89E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
Lethal factor
(Bacillus anthracis) | BDBM50099857
(ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsae...)Show InChI InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.14E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of recombinant anthrax lethal factor after 30 mins by fluorescence assay |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50099857
(ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsae...)Show InChI InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 after 30 mins |
J Med Chem 54: 591-602 (2011)
Article DOI: 10.1021/jm101266s BindingDB Entry DOI: 10.7270/Q2154HBV |
More data for this Ligand-Target Pair | |