Found 29 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417820
(CHEMBL1669396)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C24H20ClNO2/c1-2-13-26-14-12-18-15-19(16-22(25)23(18)24(26)27)17-8-10-21(11-9-17)28-20-6-4-3-5-7-20/h3-12,14-16H,2,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417840
(CHEMBL1669390)Show InChI InChI=1S/C18H17ClN2O2/c1-3-7-21-8-6-12-9-14(10-15(19)17(12)18(21)22)13-4-5-16(23-2)20-11-13/h4-6,8-11H,3,7H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417835
(CHEMBL1669384)Show InChI InChI=1S/C18H17ClN2O2/c1-2-7-21-8-5-14-9-15(10-16(19)17(14)18(21)22)23-12-13-4-3-6-20-11-13/h3-6,8-11H,2,7,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417836
(CHEMBL1669385)Show InChI InChI=1S/C18H18ClN3O/c1-2-7-22-8-5-14-9-15(10-16(19)17(14)18(22)23)21-12-13-4-3-6-20-11-13/h3-6,8-11,21H,2,7,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417837
(CHEMBL1669386)Show InChI InChI=1S/C19H19ClN2O2/c1-2-8-22-9-5-15-11-16(12-17(20)18(15)19(22)23)24-10-6-14-4-3-7-21-13-14/h3-5,7,9,11-13H,2,6,8,10H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417838
(CHEMBL1669388)Show InChI InChI=1S/C19H20ClN3O/c1-4-8-23-9-7-13-10-15(11-16(20)18(13)19(23)24)14-5-6-17(21-12-14)22(2)3/h5-7,9-12H,4,8H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417817
(CHEMBL1669393)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCCc2ccccc2)nc1 Show InChI InChI=1S/C25H23ClN2O2/c1-2-12-28-13-10-19-15-21(16-22(26)24(19)25(28)29)20-8-9-23(27-17-20)30-14-11-18-6-4-3-5-7-18/h3-10,13,15-17H,2,11-12,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417824
(CHEMBL1669400)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2ccc(nc2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H20ClF3N2O2/c1-2-10-31-11-9-18-12-19(13-21(26)23(18)24(31)32)17-4-6-20(7-5-17)33-15-16-3-8-22(30-14-16)25(27,28)29/h3-9,11-14H,2,10,15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417828
(CHEMBL1669377)Show InChI InChI=1S/C16H19ClN2O2/c1-2-4-19-5-3-12-10-13(18-6-8-21-9-7-18)11-14(17)15(12)16(19)20/h3,5,10-11H,2,4,6-9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417831
(CHEMBL1669380)Show InChI InChI=1S/C17H15ClN2O/c1-2-8-20-9-5-13-10-14(12-3-6-19-7-4-12)11-15(18)16(13)17(20)21/h3-7,9-11H,2,8H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417832
(CHEMBL1669381)Show InChI InChI=1S/C17H15ClN2O/c1-2-7-20-8-5-12-9-14(13-4-3-6-19-11-13)10-15(18)16(12)17(20)21/h3-6,8-11H,2,7H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417841
(CHEMBL1669387)Show InChI InChI=1S/C20H21ClN2O2/c1-2-9-23-10-7-16-12-17(13-18(21)19(16)20(23)24)25-11-4-6-15-5-3-8-22-14-15/h3,5,7-8,10,12-14H,2,4,6,9,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417822
(CHEMBL1669398)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2cccnc2)cc1 Show InChI InChI=1S/C24H21ClN2O2/c1-2-11-27-12-9-19-13-20(14-22(25)23(19)24(27)28)18-5-7-21(8-6-18)29-16-17-4-3-10-26-15-17/h3-10,12-15H,2,11,16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417829
(CHEMBL1669378)Show InChI InChI=1S/C17H21ClN2O2/c1-2-6-20-7-3-12-10-13(11-15(18)16(12)17(20)22)19-8-4-14(21)5-9-19/h3,7,10-11,14,21H,2,4-6,8-9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417834
(CHEMBL1669383)Show InChI InChI=1S/C15H14ClN3O/c1-2-4-19-5-3-10-6-11(12-8-17-18-9-12)7-13(16)14(10)15(19)20/h3,5-9H,2,4H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417839
(CHEMBL1669389)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(nc1)N1CCOCC1 Show InChI InChI=1S/C21H22ClN3O2/c1-2-6-25-7-5-15-12-17(13-18(22)20(15)21(25)26)16-3-4-19(23-14-16)24-8-10-27-11-9-24/h3-5,7,12-14H,2,6,8-11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417823
(CHEMBL1669399)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2ccc(Cl)nc2)cc1 Show InChI InChI=1S/C24H20Cl2N2O2/c1-2-10-28-11-9-18-12-19(13-21(25)23(18)24(28)29)17-4-6-20(7-5-17)30-15-16-3-8-22(26)27-14-16/h3-9,11-14H,2,10,15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417833
(CHEMBL1669382)Show InChI InChI=1S/C16H14ClN3O/c1-2-4-20-5-3-11-6-12(13-8-18-10-19-9-13)7-14(17)15(11)16(20)21/h3,5-10H,2,4H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417819
(CHEMBL1669395)Show InChI InChI=1S/C19H18ClNO2/c1-3-9-21-10-8-14-11-15(12-17(20)18(14)19(21)22)13-4-6-16(23-2)7-5-13/h4-8,10-12H,3,9H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417830
(CHEMBL1669379)Show InChI InChI=1S/C16H20ClN3O/c1-2-6-20-7-3-12-10-13(19-8-4-18-5-9-19)11-14(17)15(12)16(20)21/h3,7,10-11,18H,2,4-6,8-9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417825
(CHEMBL1669401)Show InChI InChI=1S/C16H20N2O2/c1-2-6-18-7-5-13-12-14(3-4-15(13)16(18)19)17-8-10-20-11-9-17/h3-5,7,12H,2,6,8-11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417827
(CHEMBL1669403)Show InChI InChI=1S/C18H15N3O/c1-2-7-21-8-5-13-9-15(14-4-3-6-20-12-14)10-16(11-19)17(13)18(21)22/h3-6,8-10,12H,2,7H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >5.01E+4 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417815
(CHEMBL1669391)Show InChI InChI=1S/C18H16ClFN2O2/c1-3-5-22-6-4-11-7-12(8-14(19)16(11)18(22)23)13-9-15(20)17(24-2)21-10-13/h4,6-10H,3,5H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417828
(CHEMBL1669377)Show InChI InChI=1S/C16H19ClN2O2/c1-2-4-19-5-3-12-10-13(18-6-8-21-9-7-18)11-14(17)15(12)16(19)20/h3,5,10-11H,2,4,6-9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in HEK293 cells assessed as induction of calcium release by FLIPR assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417816
(CHEMBL1669392)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(Oc2ccccc2)nc1 Show InChI InChI=1S/C23H19ClN2O2/c1-2-11-26-12-10-16-13-18(14-20(24)22(16)23(26)27)17-8-9-21(25-15-17)28-19-6-4-3-5-7-19/h3-10,12-15H,2,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417818
(CHEMBL1669394)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2cccnc2)nc1 Show InChI InChI=1S/C23H20ClN3O2/c1-2-9-27-10-7-17-11-19(12-20(24)22(17)23(27)28)18-5-6-21(26-14-18)29-15-16-4-3-8-25-13-16/h3-8,10-14H,2,9,15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417821
(CHEMBL1669397)Show SMILES CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(Oc2ccncc2)cc1 Show InChI InChI=1S/C23H19ClN2O2/c1-2-12-26-13-9-17-14-18(15-21(24)22(17)23(26)27)16-3-5-19(6-4-16)28-20-7-10-25-11-8-20/h3-11,13-15H,2,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50417826
(CHEMBL1669402)Show InChI InChI=1S/C17H16N2O/c1-2-9-19-10-7-14-11-13(5-6-16(14)17(19)20)15-4-3-8-18-12-15/h3-8,10-12H,2,9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description
Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048
BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this
Ligand-Target Pair | |
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