Found 52 hits for monomerid = 26431 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 1 |
J Med Chem 45: 3171-83 (2002)
BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 1
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| PubMed
| 701 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 5
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated. |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 789 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor 4
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 868 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| PubMed
| 940 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Binding affinity against human GluR6 |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 2 |
J Med Chem 45: 3171-83 (2002)
BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | |
Glutamate receptor 1
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 4 |
J Med Chem 45: 3171-83 (2002)
BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Rattus norvegicus) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from rat GLUK6 expressed in HEK293 cells |
J Med Chem 49: 2579-92 (2006)
Article DOI: 10.1021/jm051086f BindingDB Entry DOI: 10.7270/Q2FQ9W76 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Glutamate receptor ionotropic, kainate 2
(Rattus norvegicus) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cells |
J Med Chem 48: 7867-81 (2005)
Article DOI: 10.1021/jm050584l BindingDB Entry DOI: 10.7270/Q2V69KCT |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Glutamate racemase
(Helicobacter pylori) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Global Structural Chemistry
Curated by ChEMBL
| Assay Description Inhibition of Helicobacter pylori glutamate racemase |
Nature 447: 817-822 (2007)
Article DOI: 10.1038/nature05689 BindingDB Entry DOI: 10.7270/Q2HX1DJ3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by PDSP Ki Database
| |
Br J Pharmacol 95: 932-8 (1988)
Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by PDSP Ki Database
| |
Br J Pharmacol 95: 932-8 (1988)
Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by PDSP Ki Database
| |
Biochemistry 24: 2401-5 (1985)
Article DOI: 10.1021/bi00331a002 BindingDB Entry DOI: 10.7270/Q2W094FK |
More data for this Ligand-Target Pair | |
Glutamate racemase
(Lactobacillus fermentum) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | KEGG
UniProtKB/SwissProt
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| Article
| 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r... |
Bioorg Med Chem Lett 7: 2265-2270 (1997)
Article DOI: 10.1016/S0960-894X(97)00413-7 BindingDB Entry DOI: 10.7270/Q2N58MVX |
More data for this Ligand-Target Pair | |
Glutamate racemase
(Lactobacillus fermentum) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | KEGG
UniProtKB/SwissProt
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| Article
| 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition towards glutamate racemase was determined and expressed as KI |
Bioorg Med Chem Lett 7: 2265-2270 (1997)
Article DOI: 10.1016/S0960-894X(97)00413-7 BindingDB Entry DOI: 10.7270/Q2N58MVX |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 7
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | n/a | 8.22E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1 |
J Med Chem 45: 4240-5 (2002)
BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4 |
J Med Chem 45: 4240-5 (2002)
BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2 |
J Med Chem 45: 4240-5 (2002)
BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5 |
J Med Chem 45: 4240-5 (2002)
BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.83E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR2 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 1
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Induction of calcium influx in HEK293 cells expressing human GLUK5 by FLIPR assay |
J Med Chem 49: 2579-92 (2006)
Article DOI: 10.1021/jm051086f BindingDB Entry DOI: 10.7270/Q2FQ9W76 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of Metabotropic glutamate receptor 5 |
J Med Chem 41: 1641-50 (1998)
Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of Metabotropic glutamate receptor 6 |
J Med Chem 41: 1641-50 (1998)
Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of metabotropic glutamate receptor 2 (mGluR2). |
J Med Chem 41: 1641-50 (1998)
Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of Metabotropic glutamate receptor 1 |
J Med Chem 41: 1641-50 (1998)
Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of Metabotropic glutamate receptor 4 |
J Med Chem 41: 1641-50 (1998)
Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonistic activity at mGlu1-alpha receptor expressed in CHO cells |
J Med Chem 39: 3188-94 (1996)
Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonistic activity at mGlu6 receptor expressed in CHO cells |
J Med Chem 39: 3188-94 (1996)
Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonistic activity at mGlu2 receptor expressed in CHO cells |
J Med Chem 39: 3188-94 (1996)
Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 4 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 2 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 1 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 7
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 5.40E+6 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 7 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 5 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 3 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Effect on Metabotropic glutamate receptor 6 |
J Med Chem 40: 3700-5 (1997)
Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9 |
More data for this Ligand-Target Pair | |
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in... |
J Med Chem 56: 3680-8 (2013)
Article DOI: 10.1021/jm400193d BindingDB Entry DOI: 10.7270/Q21V5GBQ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a |
Janssen-Cilag SA
Curated by ChEMBL
| Assay Description Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay |
Bioorg Med Chem Lett 21: 971-6 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.048 BindingDB Entry DOI: 10.7270/Q2JD4Z18 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.31E+5 | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Agonist activity at recombinant GluR5 |
Eur J Med Chem 45: 69-77 (2010)
Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.70E+5 | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Agonist activity at recombinant GluR6 |
Eur J Med Chem 45: 69-77 (2010)
Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.88E+3 | n/a | n/a | n/a | n/a |
INSA de Rouen and Universit£ de Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured e... |
Bioorg Med Chem 20: 4716-26 (2012)
Article DOI: 10.1016/j.bmc.2012.06.006 BindingDB Entry DOI: 10.7270/Q2BG2Q2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 8
(Rattus norvegicus (Rat)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.32E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
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Patents
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| PubMed
| n/a | n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description Effective concentration against human GluR6 expressed in HEK293 cells |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |