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PubMed code 21440447

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346713
PNG
(CHEMBL1797447)
Show SMILES ClCC(=O)Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346718
PNG
(CHEMBL1797553)
Show SMILES Clc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H19ClN2O4S2/c21-17-6-10-20(11-7-17)29(26,27)23-18-8-12-19(13-9-18)28(24,25)22-15-14-16-4-2-1-3-5-16/h1-13,22-23H,14-15H2
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n/an/a 5.00E+3n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346716
PNG
(CHEMBL1797454)
Show SMILES Clc1ccc(cc1Cl)C(=O)Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H18Cl2N2O3S/c22-19-11-6-16(14-20(19)23)21(26)25-17-7-9-18(10-8-17)29(27,28)24-13-12-15-4-2-1-3-5-15/h1-11,14,24H,12-13H2,(H,25,26)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346710
PNG
(CHEMBL1797443)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H20N2O3S/c26-21-10-14-23(15-11-21)31(29,30)24-16-12-22(13-17-24)27-25(28)20-8-6-19(7-9-20)18-4-2-1-3-5-18/h1-17H,26H2,(H,27,28)
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n/an/a 1.18E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346711
PNG
(CHEMBL1797445)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)c2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C26H20N2O4S/c29-25(19-7-3-1-4-8-19)27-21-11-15-23(16-12-21)33(31,32)24-17-13-22(14-18-24)28-26(30)20-9-5-2-6-10-20/h1-18H,(H,27,29)(H,28,30)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346719
PNG
(CHEMBL1269351)
Show SMILES Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2
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n/an/a 2.67E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346712
PNG
(CHEMBL1797446)
Show SMILES O=C(Cc1ccccc1)Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C28H24N2O4S/c31-27(19-21-7-3-1-4-8-21)29-23-11-15-25(16-12-23)35(33,34)26-17-13-24(14-18-26)30-28(32)20-22-9-5-2-6-10-22/h1-18H,19-20H2,(H,29,31)(H,30,32)
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n/an/a 3.04E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346714
PNG
(CHEMBL1797448)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H15ClN2O4S2/c19-13-1-7-18(8-2-13)27(24,25)21-15-5-11-17(12-6-15)26(22,23)16-9-3-14(20)4-10-16/h1-12,21H,20H2
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n/an/a 3.51E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346709
PNG
(CHEMBL1795366)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C19H15ClN2O3S/c20-14-3-1-13(2-4-14)19(23)22-16-7-11-18(12-8-16)26(24,25)17-9-5-15(21)6-10-17/h1-12H,21H2,(H,22,23)
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n/an/a 4.59E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346715
PNG
(CHEMBL1797453)
Show SMILES Clc1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H19ClN2O3S/c22-18-8-6-17(7-9-18)21(25)24-19-10-12-20(13-11-19)28(26,27)23-15-14-16-4-2-1-3-5-16/h1-13,23H,14-15H2,(H,24,25)
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n/an/a 4.89E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346721
PNG
(CHEMBL440550)
Show SMILES Nc1ccc(cc1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C15H16N2O/c16-14-8-6-13(7-9-14)15(18)17-11-10-12-4-2-1-3-5-12/h1-9H,10-11,16H2,(H,17,18)
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n/an/a 4.97E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346722
PNG
(CHEMBL1797441)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3S/c20-15-6-10-17(11-7-15)25(23,24)18-12-8-16(9-13-18)21-19(22)14-4-2-1-3-5-14/h1-13H,20H2,(H,21,22)
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n/an/a 6.56E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase SETD7


(Homo sapiens (Human))		BDBM50346710
PNG
(CHEMBL1797443)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H20N2O3S/c26-21-10-14-23(15-11-21)31(29,30)24-16-12-22(13-17-24)27-25(28)20-8-6-19(7-9-20)18-4-2-1-3-5-18/h1-17H,26H2,(H,27,28)
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n/an/a 6.64E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of methyl transferase activity of SET7/9 using biotinylated histone H3(1-21) substrate by In-vitro time resolved fluorescence immunosorben...

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346717
PNG
(CHEMBL1797551)
Show SMILES Ic1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H19IN2O3S/c22-18-8-6-17(7-9-18)21(25)24-19-10-12-20(13-11-19)28(26,27)23-15-14-16-4-2-1-3-5-16/h1-13,23H,14-15H2,(H,24,25)
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n/an/a 6.81E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 1 [11-371]


(Homo sapiens (Human))		BDBM50346720
PNG
(CHEMBL1797556)
Show SMILES Nc1ccc(cc1)S(=O)(=O)NCc1ccccn1
Show InChI InChI=1S/C12H13N3O2S/c13-10-4-6-12(7-5-10)18(16,17)15-9-11-3-1-2-8-14-11/h1-8,15H,9,13H2
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n/an/a 7.07E+4n/an/an/an/an/an/a



Albert-Ludwigs-University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRMT1-mediated arginine methylation using nonhistone protein Npl3 substrate by ELISA

Bioorg Med Chem 19: 3717-31 (2011)


Article DOI: 10.1016/j.bmc.2011.02.032
BindingDB Entry DOI: 10.7270/Q28P60VG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%