| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 [11-371] |
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| Ligand | BDBM50346717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_753235 (CHEMBL1799390) |
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| IC50 | 68100±n/a nM |
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| Citation |  Bissinger, EM; Heinke, R; Spannhoff, A; Eberlin, A; Metzger, E; Cura, V; Hassenboehler, P; Cavarelli, J; Schüle, R; Bedford, MT; Sippl, W; Jung, M Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem19:3717-31 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 [11-371] |
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| Name: | Protein arginine N-methyltransferase 1 [11-371] |
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| Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
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| Type: | Protein |
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| Mol. Mass.: | 41506.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99873[11-371] |
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| Residue: | 361 |
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| Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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| BDBM50346717 |
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| n/a |
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| Name | BDBM50346717 |
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| Synonyms: | CHEMBL1797551 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19IN2O3S |
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| Mol. Mass. | 506.357 |
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| SMILES | Ic1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1 |
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| Structure | 
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