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PubMed code 21899370

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 4.60n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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n/an/a 4.70n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393236
PNG
(CHEMBL2151432)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393236
PNG
(CHEMBL2151432)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17+/m1/s1
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n/an/a 5.37n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393235
PNG
(CHEMBL2151436)
Show SMILES C[C@@H](OCCCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H27NO3/c1-3-4-13-19(22)21-15-18(20(21)23)16(2)24-14-9-8-12-17-10-6-5-7-11-17/h3,5-7,10-11,16,18H,1,4,8-9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393235
PNG
(CHEMBL2151436)
Show SMILES C[C@@H](OCCCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H27NO3/c1-3-4-13-19(22)21-15-18(20(21)23)16(2)24-14-9-8-12-17-10-6-5-7-11-17/h3,5-7,10-11,16,18H,1,4,8-9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8.13n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26740
PNG
(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Show SMILES O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26)
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n/an/a 33n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393240
PNG
(CHEMBL2151435)
Show SMILES C[C@@H](OCCCCc1ccccc1)C1CN(C1)C(=O)CCC=C |r|
Show InChI InChI=1S/C20H29NO2/c1-3-4-13-20(22)21-15-19(16-21)17(2)23-14-9-8-12-18-10-6-5-7-11-18/h3,5-7,10-11,17,19H,1,4,8-9,12-16H2,2H3/t17-/m1/s1
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n/an/a 2.88E+3n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393240
PNG
(CHEMBL2151435)
Show SMILES C[C@@H](OCCCCc1ccccc1)C1CN(C1)C(=O)CCC=C |r|
Show InChI InChI=1S/C20H29NO2/c1-3-4-13-20(22)21-15-19(16-21)17(2)23-14-9-8-12-18-10-6-5-7-11-18/h3,5-7,10-11,17,19H,1,4,8-9,12-16H2,2H3/t17-/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393237
PNG
(CHEMBL2151043)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(CCCC=C)C1=O |r|
Show InChI InChI=1S/C20H27NO3/c1-3-4-8-14-21-15-18(20(21)23)16(2)24-19(22)13-9-12-17-10-6-5-7-11-17/h3,5-7,10-11,16,18H,1,4,8-9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8.28E+4n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393237
PNG
(CHEMBL2151043)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(CCCC=C)C1=O |r|
Show InChI InChI=1S/C20H27NO3/c1-3-4-8-14-21-15-18(20(21)23)16(2)24-19(22)13-9-12-17-10-6-5-7-11-17/h3,5-7,10-11,16,18H,1,4,8-9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8.32E+4n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393238
PNG
(CHEMBL2151433)
Show SMILES C[C@@H](OCCCCc1ccccc1)[C@@H]1CN(CCCC=C)C1=O |r|
Show InChI InChI=1S/C20H29NO2/c1-3-4-9-14-21-16-19(20(21)22)17(2)23-15-10-8-13-18-11-6-5-7-12-18/h3,5-7,11-12,17,19H,1,4,8-10,13-16H2,2H3/t17-,19+/m1/s1
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n/an/a 8.86E+4n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393238
PNG
(CHEMBL2151433)
Show SMILES C[C@@H](OCCCCc1ccccc1)[C@@H]1CN(CCCC=C)C1=O |r|
Show InChI InChI=1S/C20H29NO2/c1-3-4-9-14-21-16-19(20(21)22)17(2)23-15-10-8-13-18-11-6-5-7-12-18/h3,5-7,11-12,17,19H,1,4,8-10,13-16H2,2H3/t17-,19+/m1/s1
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n/an/a 8.91E+4n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393239
PNG
(CHEMBL2151434)
Show SMILES C[C@@H](OCCCCc1ccccc1)C1CN(CCCC=C)C1 |r|
Show InChI InChI=1S/C20H31NO/c1-3-4-9-14-21-16-20(17-21)18(2)22-15-10-8-13-19-11-6-5-7-12-19/h3,5-7,11-12,18,20H,1,4,8-10,13-17H2,2H3/t18-/m1/s1
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n/an/a>3.16E+5n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50393239
PNG
(CHEMBL2151434)
Show SMILES C[C@@H](OCCCCc1ccccc1)C1CN(CCCC=C)C1 |r|
Show InChI InChI=1S/C20H31NO/c1-3-4-9-14-21-16-20(17-21)18(2)22-15-10-8-13-19-11-6-5-7-12-19/h3,5-7,11-12,18,20H,1,4,8-10,13-17H2,2H3/t18-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting

J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%