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PubMed code 22083916

Compile data set for download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125938
PNG
(6-Methoxy-N,9-bis[ (1-{[(2R,3S,4S,5R,6S)-3,4,5-tri...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58+,59+,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a 1.50E+3n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125935
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57-,58-,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a 2.20E+3n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125938
PNG
(6-Methoxy-N,9-bis[ (1-{[(2R,3S,4S,5R,6S)-3,4,5-tri...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58+,59+,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a 2.90E+3n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125936
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3S,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57+,58+,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a 3.20E+3n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125931
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30-,31+,32-,35+/m1/s1
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n/an/a 7.20E+3n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125937
PNG
(6-Methoxy-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58-,59-,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a 7.90E+3n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125935
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57-,58-,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a 1.10E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125932
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30+,31+,32-,35+/m1/s1
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n/an/a 1.11E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125937
PNG
(6-Methoxy-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58-,59-,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a 1.62E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125936
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3S,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57+,58+,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a 1.80E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125938
PNG
(6-Methoxy-N,9-bis[ (1-{[(2R,3S,4S,5R,6S)-3,4,5-tri...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58+,59+,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a 2.49E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125931
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30-,31+,32-,35+/m1/s1
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n/an/a 2.99E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125938
PNG
(6-Methoxy-N,9-bis[ (1-{[(2R,3S,4S,5R,6S)-3,4,5-tri...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58+,59+,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a 3.57E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125932
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30+,31+,32-,35+/m1/s1
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n/an/a 5.36E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM50208877
PNG
(2-amino-6-chloropurine | 6-Cl-purine (1) | 6-chlor...)
Show SMILES Nc1nc(Cl)c2[nH]cnc2n1
Show InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
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n/an/a 5.97E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125928
PNG
(6-Chloro-N,9-di(prop-2-yn-1-yl)-9H-purin-2-amine (...)
Show SMILES Clc1nc(NCC#C)nc2n(CC#C)cnc12
Show InChI InChI=1S/C11H8ClN5/c1-3-5-13-11-15-9(12)8-10(16-11)17(6-4-2)7-14-8/h1-2,7H,5-6H2,(H,13,15,16)
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n/an/a 7.57E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125928
PNG
(6-Chloro-N,9-di(prop-2-yn-1-yl)-9H-purin-2-amine (...)
Show SMILES Clc1nc(NCC#C)nc2n(CC#C)cnc12
Show InChI InChI=1S/C11H8ClN5/c1-3-5-13-11-15-9(12)8-10(16-11)17(6-4-2)7-14-8/h1-2,7H,5-6H2,(H,13,15,16)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125935
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57-,58-,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM50208877
PNG
(2-amino-6-chloropurine | 6-Cl-purine (1) | 6-chlor...)
Show SMILES Nc1nc(Cl)c2[nH]cnc2n1
Show InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125935
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57-,58-,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125934
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31+,32+,33-,36+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125936
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3S,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57+,58+,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125937
PNG
(6-Methoxy-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58-,59-,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125933
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31-,32+,33-,36+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM50208877
PNG
(2-amino-6-chloropurine | 6-Cl-purine (1) | 6-chlor...)
Show SMILES Nc1nc(Cl)c2[nH]cnc2n1
Show InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125935
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57-,58-,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125931
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30-,31+,32-,35+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125932
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30+,31+,32-,35+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125933
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31-,32+,33-,36+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125933
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31-,32+,33-,36+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125929
PNG
(2-Amino-6-chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(Cn2cnc3c(Cl)nc(N)nc23)nn1
Show InChI InChI=1S/C22H25ClN8O9/c1-9(32)36-7-14-16(37-10(2)33)17(38-11(3)34)18(39-12(4)35)21(40-14)31-6-13(28-29-31)5-30-8-25-15-19(23)26-22(24)27-20(15)30/h6,8,14,16-18,21H,5,7H2,1-4H3,(H2,24,26,27)/t14-,16-,17+,18-,21+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125931
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30-,31+,32-,35+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125930
PNG
(6-Chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d-glucopy...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(CNc2nc(Cl)c3ncn(Cc4cn(nn4)[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)c3n2)nn1
Show InChI InChI=1S/C39H46ClN11O18/c1-16(52)60-13-26-29(62-18(3)54)31(64-20(5)56)33(66-22(7)58)37(68-26)50-11-24(45-47-50)9-41-39-43-35(40)28-36(44-39)49(15-42-28)10-25-12-51(48-46-25)38-34(67-23(8)59)32(65-21(6)57)30(63-19(4)55)27(69-38)14-61-17(2)53/h11-12,15,26-27,29-34,37-38H,9-10,13-14H2,1-8H3,(H,41,43,44)/t26-,27-,29-,30-,31+,32+,33-,34-,37+,38+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125934
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31+,32+,33-,36+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125929
PNG
(2-Amino-6-chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(Cn2cnc3c(Cl)nc(N)nc23)nn1
Show InChI InChI=1S/C22H25ClN8O9/c1-9(32)36-7-14-16(37-10(2)33)17(38-11(3)34)18(39-12(4)35)21(40-14)31-6-13(28-29-31)5-30-8-25-15-19(23)26-22(24)27-20(15)30/h6,8,14,16-18,21H,5,7H2,1-4H3,(H2,24,26,27)/t14-,16-,17+,18-,21+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125927
PNG
(6-Chloro-9-(prop-2-yn-1-yl)-9H-purin-2-amine (2))
Show SMILES Nc1nc(Cl)c2ncn(CC#C)c2n1
Show InChI InChI=1S/C8H6ClN5/c1-2-3-14-4-11-5-6(9)12-8(10)13-7(5)14/h1,4H,3H2,(H2,10,12,13)
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125928
PNG
(6-Chloro-N,9-di(prop-2-yn-1-yl)-9H-purin-2-amine (...)
Show SMILES Clc1nc(NCC#C)nc2n(CC#C)cnc12
Show InChI InChI=1S/C11H8ClN5/c1-3-5-13-11-15-9(12)8-10(16-11)17(6-4-2)7-14-8/h1-2,7H,5-6H2,(H,13,15,16)
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125930
PNG
(6-Chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d-glucopy...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(CNc2nc(Cl)c3ncn(Cc4cn(nn4)[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)c3n2)nn1
Show InChI InChI=1S/C39H46ClN11O18/c1-16(52)60-13-26-29(62-18(3)54)31(64-20(5)56)33(66-22(7)58)37(68-26)50-11-24(45-47-50)9-41-39-43-35(40)28-36(44-39)49(15-42-28)10-25-12-51(48-46-25)38-34(67-23(8)59)32(65-21(6)57)30(63-19(4)55)27(69-38)14-61-17(2)53/h11-12,15,26-27,29-34,37-38H,9-10,13-14H2,1-8H3,(H,41,43,44)/t26-,27-,29-,30-,31+,32+,33-,34-,37+,38+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM50208877
PNG
(2-amino-6-chloropurine | 6-Cl-purine (1) | 6-chlor...)
Show SMILES Nc1nc(Cl)c2[nH]cnc2n1
Show InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM50208877
PNG
(2-amino-6-chloropurine | 6-Cl-purine (1) | 6-chlor...)
Show SMILES Nc1nc(Cl)c2[nH]cnc2n1
Show InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125932
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30+,31+,32-,35+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125938
PNG
(6-Methoxy-N,9-bis[ (1-{[(2R,3S,4S,5R,6S)-3,4,5-tri...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58+,59+,60+,61+,62-,63-,66+,67+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125927
PNG
(6-Chloro-9-(prop-2-yn-1-yl)-9H-purin-2-amine (2))
Show SMILES Nc1nc(Cl)c2ncn(CC#C)c2n1
Show InChI InChI=1S/C8H6ClN5/c1-2-3-14-4-11-5-6(9)12-8(10)13-7(5)14/h1,4H,3H2,(H2,10,12,13)
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125928
PNG
(6-Chloro-N,9-di(prop-2-yn-1-yl)-9H-purin-2-amine (...)
Show SMILES Clc1nc(NCC#C)nc2n(CC#C)cnc12
Show InChI InChI=1S/C11H8ClN5/c1-3-5-13-11-15-9(12)8-10(16-11)17(6-4-2)7-14-8/h1-2,7H,5-6H2,(H,13,15,16)
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125936
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3S,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57+,58+,59+,60+,61-,62-,65+,66+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125933
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31-,32+,33-,36+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125929
PNG
(2-Amino-6-chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(Cn2cnc3c(Cl)nc(N)nc23)nn1
Show InChI InChI=1S/C22H25ClN8O9/c1-9(32)36-7-14-16(37-10(2)33)17(38-11(3)34)18(39-12(4)35)21(40-14)31-6-13(28-29-31)5-30-8-25-15-19(23)26-22(24)27-20(15)30/h6,8,14,16-18,21H,5,7H2,1-4H3,(H2,24,26,27)/t14-,16-,17+,18-,21+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125934
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31+,32+,33-,36+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125934
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31+,32+,33-,36+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125937
PNG
(6-Methoxy-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58-,59-,60+,61+,62-,63-,66+,67+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125927
PNG
(6-Chloro-9-(prop-2-yn-1-yl)-9H-purin-2-amine (2))
Show SMILES Nc1nc(Cl)c2ncn(CC#C)c2n1
Show InChI InChI=1S/C8H6ClN5/c1-2-3-14-4-11-5-6(9)12-8(10)13-7(5)14/h1,4H,3H2,(H2,10,12,13)
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125930
PNG
(6-Chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d-glucopy...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(CNc2nc(Cl)c3ncn(Cc4cn(nn4)[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)c3n2)nn1
Show InChI InChI=1S/C39H46ClN11O18/c1-16(52)60-13-26-29(62-18(3)54)31(64-20(5)56)33(66-22(7)58)37(68-26)50-11-24(45-47-50)9-41-39-43-35(40)28-36(44-39)49(15-42-28)10-25-12-51(48-46-25)38-34(67-23(8)59)32(65-21(6)57)30(63-19(4)55)27(69-38)14-61-17(2)53/h11-12,15,26-27,29-34,37-38H,9-10,13-14H2,1-8H3,(H,41,43,44)/t26-,27-,29-,30-,31+,32+,33-,34-,37+,38+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125930
PNG
(6-Chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d-glucopy...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(CNc2nc(Cl)c3ncn(Cc4cn(nn4)[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)c3n2)nn1
Show InChI InChI=1S/C39H46ClN11O18/c1-16(52)60-13-26-29(62-18(3)54)31(64-20(5)56)33(66-22(7)58)37(68-26)50-11-24(45-47-50)9-41-39-43-35(40)28-36(44-39)49(15-42-28)10-25-12-51(48-46-25)38-34(67-23(8)59)32(65-21(6)57)30(63-19(4)55)27(69-38)14-61-17(2)53/h11-12,15,26-27,29-34,37-38H,9-10,13-14H2,1-8H3,(H,41,43,44)/t26-,27-,29-,30-,31+,32+,33-,34-,37+,38+/m1/s1
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East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125937
PNG
(6-Methoxy-N,9-bis[(1-{[(2R,3R,4S,5R,6S)-3,4,5-tris...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(OC)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C68H73N11O11/c1-80-65-57-64(77(46-70-57)35-54-37-79(76-74-54)39-56-59(84-41-48-24-12-5-13-25-48)61(86-43-50-28-16-7-17-29-50)63(67(82-3)90-56)88-45-52-32-20-9-21-33-52)71-68(72-65)69-34-53-36-78(75-73-53)38-55-58(83-40-47-22-10-4-11-23-47)60(85-42-49-26-14-6-15-27-49)62(66(81-2)89-55)87-44-51-30-18-8-19-31-51/h4-33,36-37,46,55-56,58-63,66-67H,34-35,38-45H2,1-3H3,(H,69,71,72)/t55-,56-,58-,59-,60+,61+,62-,63-,66+,67+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125929
PNG
(2-Amino-6-chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(Cn2cnc3c(Cl)nc(N)nc23)nn1
Show InChI InChI=1S/C22H25ClN8O9/c1-9(32)36-7-14-16(37-10(2)33)17(38-11(3)34)18(39-12(4)35)21(40-14)31-6-13(28-29-31)5-30-8-25-15-19(23)26-22(24)27-20(15)30/h6,8,14,16-18,21H,5,7H2,1-4H3,(H2,24,26,27)/t14-,16-,17+,18-,21+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125931
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30-,31+,32-,35+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125928
PNG
(6-Chloro-N,9-di(prop-2-yn-1-yl)-9H-purin-2-amine (...)
Show SMILES Clc1nc(NCC#C)nc2n(CC#C)cnc12
Show InChI InChI=1S/C11H8ClN5/c1-3-5-13-11-15-9(12)8-10(16-11)17(6-4-2)7-14-8/h1-2,7H,5-6H2,(H,13,15,16)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11


(Homo sapiens (Human))		BDBM125929
PNG
(2-Amino-6-chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(Cn2cnc3c(Cl)nc(N)nc23)nn1
Show InChI InChI=1S/C22H25ClN8O9/c1-9(32)36-7-14-16(37-10(2)33)17(38-11(3)34)18(39-12(4)35)21(40-14)31-6-13(28-29-31)5-30-8-25-15-19(23)26-22(24)27-20(15)30/h6,8,14,16-18,21H,5,7H2,1-4H3,(H2,24,26,27)/t14-,16-,17+,18-,21+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))		BDBM125927
PNG
(6-Chloro-9-(prop-2-yn-1-yl)-9H-purin-2-amine (2))
Show SMILES Nc1nc(Cl)c2ncn(CC#C)c2n1
Show InChI InChI=1S/C8H6ClN5/c1-2-3-14-4-11-5-6(9)12-8(10)13-7(5)14/h1,4H,3H2,(H2,10,12,13)
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125934
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31+,32+,33-,36+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F


(Homo sapiens (Human))		BDBM125936
PNG
(6-Chloro-N,9-bis[(1-{[(2R,3S,4S,5R,6S)-3,4,5-tris(...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(CNc3nc(Cl)c4ncn(Cc5cn(C[C@H]6O[C@H](OC)[C@H](OCc7ccccc7)[C@@H](OCc7ccccc7)[C@H]6OCc6ccccc6)nn5)c4n3)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C67H70ClN11O10/c1-80-65-61(86-43-50-29-17-7-18-30-50)59(84-41-48-25-13-5-14-26-48)57(82-39-46-21-9-3-10-22-46)54(88-65)37-78-35-52(73-75-78)33-69-67-71-63(68)56-64(72-67)77(45-70-56)34-53-36-79(76-74-53)38-55-58(83-40-47-23-11-4-12-24-47)60(85-42-49-27-15-6-16-28-49)62(66(81-2)89-55)87-44-51-31-19-8-20-32-51/h3-32,35-36,45,54-55,57-62,65-66H,33-34,37-44H2,1-2H3,(H,69,71,72)/t54-,55-,57+,58+,59+,60+,61-,62-,65+,66+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125930
PNG
(6-Chloro-9-{[1-(2,3,4,6-tetra-O-acetyl-b-d-glucopy...)
Show SMILES CC(=O)OC[C@H]1O[C@@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)n1cc(CNc2nc(Cl)c3ncn(Cc4cn(nn4)[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)c3n2)nn1
Show InChI InChI=1S/C39H46ClN11O18/c1-16(52)60-13-26-29(62-18(3)54)31(64-20(5)56)33(66-22(7)58)37(68-26)50-11-24(45-47-50)9-41-39-43-35(40)28-36(44-39)49(15-42-28)10-25-12-51(48-46-25)38-34(67-23(8)59)32(65-21(6)57)30(63-19(4)55)27(69-38)14-61-17(2)53/h11-12,15,26-27,29-34,37-38H,9-10,13-14H2,1-8H3,(H,41,43,44)/t26-,27-,29-,30-,31+,32+,33-,34-,37+,38+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125932
PNG
(Methyl 6-{4-[(2-Amino-6-chloro-9H-purin-9-yl)methy...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(Cl)nc(N)nc34)nn2)[C@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C36H37ClN8O5/c1-46-35-32(49-22-26-15-9-4-10-16-26)31(48-21-25-13-7-3-8-14-25)30(47-20-24-11-5-2-6-12-24)28(50-35)19-45-18-27(42-43-45)17-44-23-39-29-33(37)40-36(38)41-34(29)44/h2-16,18,23,28,30-32,35H,17,19-22H2,1H3,(H2,38,40,41)/t28-,30+,31+,32-,35+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6


(Homo sapiens (Human))		BDBM125933
PNG
(Methyl 6-{4-[(2-Amino-6-methoxy-9H-purin-9-yl)meth...)
Show SMILES CO[C@H]1O[C@H](Cn2cc(Cn3cnc4c(OC)nc(N)nc34)nn2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1
Show InChI InChI=1S/C37H40N8O6/c1-46-35-30-34(40-37(38)41-35)44(24-39-30)18-28-19-45(43-42-28)20-29-31(48-21-25-12-6-3-7-13-25)32(49-22-26-14-8-4-9-15-26)33(36(47-2)51-29)50-23-27-16-10-5-11-17-27/h3-17,19,24,29,31-33,36H,18,20-23H2,1-2H3,(H2,38,40,41)/t29-,31-,32+,33-,36+/m1/s1
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n/an/a>8.00E+4n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1


(Homo sapiens (Human))		BDBM125927
PNG
(6-Chloro-9-(prop-2-yn-1-yl)-9H-purin-2-amine (2))
Show SMILES Nc1nc(Cl)c2ncn(CC#C)c2n1
Show InChI InChI=1S/C8H6ClN5/c1-2-3-14-4-11-5-6(9)12-8(10)13-7(5)14/h1,4H,3H2,(H2,10,12,13)
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n/an/a 2.32E+5n/an/an/an/a6.5n/a



East China University of Science and Technology



Assay Description
Enzymatic activity of enzyme was evaluated using pNPP assay. Briefly, a reaction mixture (100 無) containing 50 mM MOPS (pH 6.5), 2 mM pNPP and recom...

Chem Biodivers 8: 2035-44 (2011)


Article DOI: 10.1002/cbdv.201000242
BindingDB Entry DOI: 10.7270/Q2668BVX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%