BindingDB logo
myBDB logout

PubMed code 22148754

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycylpeptide N-tetradecanoyltransferase


(Leishmania major)
BDBM50364113
PNG
(CHEMBL1230468)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major N-myristoyltransferase using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins ...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364113
PNG
(CHEMBL1230468)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364135
PNG
(CHEMBL1951295)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cc(Cl)c(c(Cl)c2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C24H29Cl2N5O2S/c1-16-23(17(2)30(4)27-16)28-34(32,33)24-21(25)13-20(14-22(24)26)19-7-5-6-18(12-19)15-31-10-8-29(3)9-11-31/h5-7,12-14,28H,8-11,15H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364127
PNG
(CHEMBL1951287)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(nc1)N1CCCC(C1)N1CCNCC1
Show InChI InChI=1S/C20H31N7O2S/c1-15-20(16(2)25(3)23-15)24-30(28,29)18-6-7-19(22-13-18)27-10-4-5-17(14-27)26-11-8-21-9-12-26/h6-7,13,17,21,24H,4-5,8-12,14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364136
PNG
(CHEMBL1951296)
Show SMILES CCN(CC)Cc1cccc(c1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C
Show InChI InChI=1S/C23H28Cl2N4O2S/c1-6-29(7-2)14-17-9-8-10-18(11-17)19-12-20(24)23(21(25)13-19)32(30,31)27-22-15(3)26-28(5)16(22)4/h8-13,27H,6-7,14H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364133
PNG
(CHEMBL1951293)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-19(25-12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 750n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364123
PNG
(CHEMBL1951283)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCCN2CCN(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C23H31N7O2S/c1-18-23(19(2)28(3)26-18)27-33(31,32)21-9-10-22(25-17-21)24-11-12-29-13-15-30(16-14-29)20-7-5-4-6-8-20/h4-10,17,27H,11-16H2,1-3H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364122
PNG
(CHEMBL1951282)
Show SMILES CN1CCC(CCNc2ccc(cn2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C19H30N6O2S/c1-14-19(15(2)25(4)22-14)23-28(26,27)17-5-6-18(21-13-17)20-10-7-16-8-11-24(3)12-9-16/h5-6,13,16,23H,7-12H2,1-4H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364121
PNG
(CHEMBL1951280)
Show SMILES CC(C)N1CCN(CCNc2ccc(cn2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C20H33N7O2S/c1-15(2)27-12-10-26(11-13-27)9-8-21-19-7-6-18(14-22-19)30(28,29)24-20-16(3)23-25(5)17(20)4/h6-7,14-15,24H,8-13H2,1-5H3,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364126
PNG
(CHEMBL1951286)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(nc1)N1CCC(C1)N1CCNCC1
Show InChI InChI=1S/C19H29N7O2S/c1-14-19(15(2)24(3)22-14)23-29(27,28)17-4-5-18(21-12-17)26-9-6-16(13-26)25-10-7-20-8-11-25/h4-5,12,16,20,23H,6-11,13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364124
PNG
(CHEMBL1951284)
Show SMILES CN1CCN(CCCNc2ccc(cn2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C19H31N7O2S/c1-15-19(16(2)25(4)22-15)23-29(27,28)17-6-7-18(21-14-17)20-8-5-9-26-12-10-24(3)11-13-26/h6-7,14,23H,5,8-13H2,1-4H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364117
PNG
(CHEMBL1951274)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCc2ccc3[nH]ccc3c2)nc1
Show InChI InChI=1S/C20H22N6O2S/c1-13-20(14(2)26(3)24-13)25-29(27,28)17-5-7-19(23-12-17)22-11-15-4-6-18-16(10-15)8-9-21-18/h4-10,12,21,25H,11H2,1-3H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364131
PNG
(CHEMBL1951291)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc(Cl)c(c(Cl)c2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C24H29Cl2N5O2S/c1-16-23(17(2)30(4)27-16)28-34(32,33)24-21(25)13-20(14-22(24)26)19-7-5-18(6-8-19)15-31-11-9-29(3)10-12-31/h5-8,13-14,28H,9-12,15H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364134
PNG
(CHEMBL1951294)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1cccc2CNCCc12
Show InChI InChI=1S/C21H22Cl2N4O2S/c1-12-20(13(2)27(3)25-12)26-30(28,29)21-18(22)9-15(10-19(21)23)16-6-4-5-14-11-24-8-7-17(14)16/h4-6,9-10,24,26H,7-8,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364118
PNG
(CHEMBL1951277)
Show SMILES CN1CCN(CCNc2ccc(cn2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C18H29N7O2S/c1-14-18(15(2)24(4)21-14)22-28(26,27)16-5-6-17(20-13-16)19-7-8-25-11-9-23(3)10-12-25/h5-6,13,22H,7-12H2,1-4H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364125
PNG
(CHEMBL1951285)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCCCn2ccnc2)nc1
Show InChI InChI=1S/C17H23N7O2S/c1-13-17(14(2)23(3)21-13)22-27(25,26)15-5-6-16(20-11-15)19-7-4-9-24-10-8-18-12-24/h5-6,8,10-12,22H,4,7,9H2,1-3H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.70E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364128
PNG
(CHEMBL1951288)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCCN2CCN(Cc3ccccc3)CC2)nc1
Show InChI InChI=1S/C24H33N7O2S/c1-19-24(20(2)29(3)27-19)28-34(32,33)22-9-10-23(26-17-22)25-11-12-30-13-15-31(16-14-30)18-21-7-5-4-6-8-21/h4-10,17,28H,11-16,18H2,1-3H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364129
PNG
(CHEMBL1951289)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCCN2CCN(CC2)C(=O)OC(C)(C)C)nc1
Show InChI InChI=1S/C22H35N7O4S/c1-16-20(17(2)27(6)25-16)26-34(31,32)18-7-8-19(24-15-18)23-9-10-28-11-13-29(14-12-28)21(30)33-22(3,4)5/h7-8,15,26H,9-14H2,1-6H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364119
PNG
(CHEMBL1951278)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCCN2CCNCC2)nc1
Show InChI InChI=1S/C17H27N7O2S/c1-13-17(14(2)23(3)21-13)22-27(25,26)15-4-5-16(20-12-15)19-8-11-24-9-6-18-7-10-24/h4-5,12,18,22H,6-11H2,1-3H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364116
PNG
(CHEMBL1951273)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCc2ccccc2)nc1
Show InChI InChI=1S/C18H21N5O2S/c1-13-18(14(2)23(3)21-13)22-26(24,25)16-9-10-17(20-12-16)19-11-15-7-5-4-6-8-15/h4-10,12,22H,11H2,1-3H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364114
PNG
(CHEMBL1951105)
Show SMILES COc1cc(C)c(c(C)c1C)S(=O)(=O)Nc1c(C)nn(C)c1C
Show InChI InChI=1S/C16H23N3O3S/c1-9-8-14(22-7)10(2)11(3)16(9)23(20,21)18-15-12(4)17-19(6)13(15)5/h8,18H,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50364113
PNG
(CHEMBL1230468)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human ERG by automated patch clamp assay


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364132
PNG
(CHEMBL1951292)
Show SMILES CCN(CC)Cc1ccc(cc1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C
Show InChI InChI=1S/C23H28Cl2N4O2S/c1-6-29(7-2)14-17-8-10-18(11-9-17)19-12-20(24)23(21(25)13-19)32(30,31)27-22-15(3)26-28(5)16(22)4/h8-13,27H,6-7,14H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364120
PNG
(CHEMBL1951279)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCCN2CCCCC2)nc1
Show InChI InChI=1S/C18H28N6O2S/c1-14-18(15(2)23(3)21-14)22-27(25,26)16-7-8-17(20-13-16)19-9-12-24-10-5-4-6-11-24/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.40E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364130
PNG
(CHEMBL1951290)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1cccc2cnccc12
Show InChI InChI=1S/C21H18Cl2N4O2S/c1-12-20(13(2)27(3)25-12)26-30(28,29)21-18(22)9-15(10-19(21)23)16-6-4-5-14-11-24-8-7-17(14)16/h4-11,26H,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))
BDBM50364115
PNG
(CHEMBL1951272)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(Cl)nc1
Show InChI InChI=1S/C11H13ClN4O2S/c1-7-11(8(2)16(3)14-7)15-19(17,18)9-4-5-10(12)13-6-9/h4-6,15H,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


J Med Chem 55: 140-52 (2012)


Article DOI: 10.1021/jm201091t
BindingDB Entry DOI: 10.7270/Q25Q4WK9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%