| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Ligand | BDBM50364116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_803806 (CHEMBL1954201) |
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| IC50 | 17000±n/a nM |
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| Citation |  Brand, S; Cleghorn, LA; McElroy, SP; Robinson, DA; Smith, VC; Hallyburton, I; Harrison, JR; Norcross, NR; Spinks, D; Bayliss, T; Norval, S; Stojanovski, L; Torrie, LS; Frearson, JA; Brenk, R; Fairlamb, AH; Ferguson, MA; Read, KD; Wyatt, PG; Gilbert, IH Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem55:140-52 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase 1 |
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| Name: | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56814.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30419 |
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| Residue: | 496 |
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| Sequence: | MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
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| BDBM50364116 |
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| n/a |
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| Name | BDBM50364116 |
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| Synonyms: | CHEMBL1951273 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5O2S |
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| Mol. Mass. | 371.457 |
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| SMILES | Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(NCc2ccccc2)nc1 |
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| Structure | 
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