Affinity Data by PubMed id=22778800

PubMed code 22778800

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50382445 (CHEMBL2023357) Show SMILES NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1 \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	894	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382446 (CHEMBL2022185) Show SMILES CCOc1ccccc1[C@H]1C[C@@H]1CN \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382453 (CHEMBL2022180) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382448 (CHEMBL2022192) Show SMILES NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	304	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.860	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.60	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50382446 (CHEMBL2022185) Show SMILES CCOc1ccccc1[C@H]1C[C@@H]1CN \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	331	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0900	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382447 (CHEMBL2022186) Show SMILES CCCOc1ccccc1[C@H]1C[C@@H]1CN \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382456 (CHEMBL2022189) Show SMILES NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382458 (CHEMBL2022193) Show SMILES NC[C@@H]1C[C@H]1c1ccccc1OCC1CC1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	978	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50382447 (CHEMBL2022186) Show SMILES CCCOc1ccccc1[C@H]1C[C@@H]1CN \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	304	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50382445 (CHEMBL2023357) Show SMILES NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	289	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382445 (CHEMBL2023357) Show SMILES NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50382448 (CHEMBL2022192) Show SMILES NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382451 (CHEMBL2022177) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.71E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382454 (CHEMBL2022181) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382456 (CHEMBL2022189) Show SMILES NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382452 (CHEMBL2022179) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.31E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382457 (CHEMBL2022190) Show SMILES NC[C@H]1C[C@@H]1c1ccccc1OCC1CCC1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382455 (CHEMBL2022187) Show SMILES CC(C)COc1ccccc1[C@H]1C[C@@H]1CN \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	254	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50382446 (CHEMBL2022185) Show SMILES CCOc1ccccc1[C@H]1C[C@@H]1CN \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.02E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382450 (CHEMBL2023356) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50382449 (CHEMBL2023355) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay				ACS Med Chem Lett 2: 929-932 (2011) Article DOI: 10.1021/ml200206z BindingDB Entry DOI: 10.7270/Q2959JKS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%