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PubMed code 22831799

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 3.5n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389433
PNG
(CHEMBL2064616)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1Br |r|
Show InChI InChI=1S/C21H30BrNO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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 9.30n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389435
PNG
(CHEMBL2064617)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C21H31NO/c23-21-15-19-9-5-4-8-18(19)14-20(21)22-12-10-17(11-13-22)16-6-2-1-3-7-16/h1-3,6-7,17-21,23H,4-5,8-15H2/t18-,19-,20?,21?/m0/s1
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 13.6n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DT...

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389433
PNG
(CHEMBL2064616)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1Br |r|
Show InChI InChI=1S/C21H30BrNO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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 13.8n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DT...

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389432
PNG
(CHEMBL2064618)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1I |r|
Show InChI InChI=1S/C21H30INO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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 20.5n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DT...

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50018078
PNG
(2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Ph...)
Show SMILES OC1CCCCC1N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2
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 22.1n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389432
PNG
(CHEMBL2064618)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1I |r|
Show InChI InChI=1S/C21H30INO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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 28.6n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50018078
PNG
(2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Ph...)
Show SMILES OC1CCCCC1N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2
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 32.9n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50018078
PNG
(2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Ph...)
Show SMILES OC1CCCCC1N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2
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 33.9n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DT...

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50389435
PNG
(CHEMBL2064617)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C21H31NO/c23-21-15-19-9-5-4-8-18(19)14-20(21)22-12-10-17(11-13-22)16-6-2-1-3-7-16/h1-3,6-7,17-21,23H,4-5,8-15H2/t18-,19-,20?,21?/m0/s1
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 74.1n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C |w:10.11|
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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 131n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50389433
PNG
(CHEMBL2064616)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1Br |r|
Show InChI InChI=1S/C21H30BrNO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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 151n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50389432
PNG
(CHEMBL2064618)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1I |r|
Show InChI InChI=1S/C21H30INO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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 242n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1 |(5.41,-4.43,;4.65,-5.78,;6.2,-5.78,;6.97,-7.12,;6.97,-4.45,;8.52,-4.1,;8.52,-2.56,;9.86,-1.78,;11.19,-2.56,;11.19,-4.1,;9.86,-4.88,;9.09,-3.78,;9.09,-2.9,;3.1,-5.81,;2.36,-7.19,;.82,-7.2,;.01,-5.88,;.78,-4.52,;2.32,-4.49,;4.65,-7.23,;3.39,-7.96,;3.38,-9.41,;4.64,-10.15,;5.91,-9.42,;5.91,-7.97,)|
Show InChI InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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 582n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM21397
PNG
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
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 1.03E+3n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C |w:10.11|
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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 1.13E+3n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM21395
PNG
(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1 |r|
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50001028
PNG
((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Show SMILES [#6]-[#6@H]1-[#6@H]-2-[#6]-c3ccc(-[#8])cc3[C@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](\[#6])-[#6] |r,TLB:16:15:1:3.4.10|
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389432
PNG
(CHEMBL2064618)
Show SMILES OC1C[C@@H]2CCCC[C@H]2CC1N1CCC(CC1)c1ccccc1I |r|
Show InChI InChI=1S/C21H30INO/c22-19-8-4-3-7-18(19)15-9-11-23(12-10-15)20-13-16-5-1-2-6-17(16)14-21(20)24/h3-4,7-8,15-17,20-21,24H,1-2,5-6,9-14H2/t16-,17-,20?,21?/m0/s1
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n/an/an/a 1.73n/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Binding affinity to VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting in presence of haloperidol

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50009602
PNG
(2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | CHEMBL8...)
Show SMILES O[C@@H]1CCCCC1N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2/t16?,17-/m1/s1
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n/an/an/a 7.40n/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Binding affinity to VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting in presence of DTG

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)		BDBM50389434
PNG
(CHEMBL2064619)
Show SMILES O[C@@H]1CCCCC1N1CCC(CC1)c1ccccc1I |r|
Show InChI InChI=1S/C17H24INO/c18-15-6-2-1-5-14(15)13-9-11-19(12-10-13)16-7-3-4-8-17(16)20/h1-2,5-6,13,16-17,20H,3-4,7-12H2/t16?,17-/m1/s1
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n/an/an/a 17.4n/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Binding affinity to VAChT in rat cerebral membrane

Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%