Affinity Data by PubMed id=22837811

PubMed code 22837811

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50320082 (1-(4-Amino-2-butyl-1H-imidazo-[4,5-c]quinolin-1-yl...) Show SMILES CCCCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50320082 (1-(4-Amino-2-butyl-1H-imidazo-[4,5-c]quinolin-1-yl...) Show SMILES CCCCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.70E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50403024 (CHEMBL195276) Show SMILES CC(C)(O)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.50E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50241029 (1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...) Show SMILES CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50403022 (CHEMBL2216760) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.13E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50403023 (CHEMBL2216759) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.70E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50403022 (CHEMBL2216760) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50241029 (1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...) Show SMILES CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50403024 (CHEMBL195276) Show SMILES CC(C)(O)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.70E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50403023 (CHEMBL2216759) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.70E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%