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PubMed code 22884988

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50390599
PNG
(CHEMBL2069579)
Show SMILES OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H22N4O3S/c30-24(23(10-17-4-2-1-3-5-17)27-14-22-15-33-16-28-22)29-21-12-19(11-20(13-21)25(31)32)18-6-8-26-9-7-18/h1-9,11-13,15-16,23,27H,10,14H2,(H,29,30)(H,31,32)/t23-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50390608
PNG
(CHEMBL2069588)
Show SMILES Cc1cc(ccn1)-c1c[nH]c(=O)c(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C24H23N5O2S/c1-16-9-18(7-8-25-16)19-11-22(23(30)27-12-19)29-24(31)21(10-17-5-3-2-4-6-17)26-13-20-14-32-15-28-20/h2-9,11-12,14-15,21,26H,10,13H2,1H3,(H,27,30)(H,29,31)/t21-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50390608
PNG
(CHEMBL2069588)
Show SMILES Cc1cc(ccn1)-c1c[nH]c(=O)c(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C24H23N5O2S/c1-16-9-18(7-8-25-16)19-11-22(23(30)27-12-19)29-24(31)21(10-17-5-3-2-4-6-17)26-13-20-14-32-15-28-20/h2-9,11-12,14-15,21,26H,10,13H2,1H3,(H,27,30)(H,29,31)/t21-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))		BDBM50390599
PNG
(CHEMBL2069579)
Show SMILES OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H22N4O3S/c30-24(23(10-17-4-2-1-3-5-17)27-14-22-15-33-16-28-22)29-21-12-19(11-20(13-21)25(31)32)18-6-8-26-9-7-18/h1-9,11-13,15-16,23,27H,10,14H2,(H,29,30)(H,31,32)/t23-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50390599
PNG
(CHEMBL2069579)
Show SMILES OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H22N4O3S/c30-24(23(10-17-4-2-1-3-5-17)27-14-22-15-33-16-28-22)29-21-12-19(11-20(13-21)25(31)32)18-6-8-26-9-7-18/h1-9,11-13,15-16,23,27H,10,14H2,(H,29,30)(H,31,32)/t23-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390578
PNG
(CHEMBL2069483)
Show SMILES N[C@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H18N4O2/c20-16(10-13-4-2-1-3-5-13)18(24)23-17-11-15(12-22-19(17)25)14-6-8-21-9-7-14/h1-9,11-12,16H,10,20H2,(H,22,25)(H,23,24)/t16-/m1/s1
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n/an/an/an/a 1.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390587
PNG
(CHEMBL2069492)
Show SMILES Cc1ccc(C[C@H](N)C(=O)Nc2cc(c[nH]c2=O)-c2ccncc2)cc1 |r|
Show InChI InChI=1S/C20H20N4O2/c1-13-2-4-14(5-3-13)10-17(21)19(25)24-18-11-16(12-23-20(18)26)15-6-8-22-9-7-15/h2-9,11-12,17H,10,21H2,1H3,(H,23,26)(H,24,25)/t17-/m0/s1
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n/an/an/an/a 6.60E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390591
PNG
(CHEMBL2069496)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCC1CC1 |r|
Show InChI InChI=1S/C23H24N4O2/c28-22-21(13-19(15-26-22)18-8-10-24-11-9-18)27-23(29)20(25-14-17-6-7-17)12-16-4-2-1-3-5-16/h1-5,8-11,13,15,17,20,25H,6-7,12,14H2,(H,26,28)(H,27,29)/t20-/m0/s1
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n/an/an/an/a 760n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390594
PNG
(CHEMBL2069574)
Show SMILES O=C(Nc1nccc(n1)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C22H20N6OS/c29-21(28-22-24-11-8-19(27-22)17-6-9-23-10-7-17)20(12-16-4-2-1-3-5-16)25-13-18-14-30-15-26-18/h1-11,14-15,20,25H,12-13H2,(H,24,27,28,29)/t20-/m0/s1
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n/an/an/an/a 360n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390596
PNG
(CHEMBL2069576)
Show SMILES COc1ccc(cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H24N4O2S/c1-31-24-8-7-20(19-9-11-26-12-10-19)14-22(24)29-25(30)23(13-18-5-3-2-4-6-18)27-15-21-16-32-17-28-21/h2-12,14,16-17,23,27H,13,15H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/an/an/a 89n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390598
PNG
(CHEMBL2069578)
Show SMILES COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 |r|
Show InChI InChI=1S/C25H24N4O2S/c1-31-24-8-7-20(14-22(24)19-9-11-26-12-10-19)29-25(30)23(13-18-5-3-2-4-6-18)27-15-21-16-32-17-28-21/h2-12,14,16-17,23,27H,13,15H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/an/an/a 240n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390603
PNG
(CHEMBL2069583)
Show SMILES Cn1ccc(n1)-c1cccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C23H23N5OS/c1-28-11-10-21(27-28)18-8-5-9-19(13-18)26-23(29)22(12-17-6-3-2-4-7-17)24-14-20-15-30-16-25-20/h2-11,13,15-16,22,24H,12,14H2,1H3,(H,26,29)/t22-/m0/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390605
PNG
(CHEMBL2069585)
Show SMILES Cn1cc(cn1)-c1cccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C23H23N5OS/c1-28-14-19(12-26-28)18-8-5-9-20(11-18)27-23(29)22(10-17-6-3-2-4-7-17)24-13-21-15-30-16-25-21/h2-9,11-12,14-16,22,24H,10,13H2,1H3,(H,27,29)/t22-/m0/s1
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n/an/an/an/a 180n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390607
PNG
(CHEMBL2069587)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C25H23N3OS/c29-25(28-22-13-7-12-21(15-22)20-10-5-2-6-11-20)24(14-19-8-3-1-4-9-19)26-16-23-17-30-18-27-23/h1-13,15,17-18,24,26H,14,16H2,(H,28,29)/t24-/m0/s1
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n/an/an/an/a 640n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390597
PNG
(CHEMBL2069577)
Show SMILES COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H24N4O2S/c1-31-23-13-20(19-7-9-26-10-8-19)12-21(14-23)29-25(30)24(11-18-5-3-2-4-6-18)27-15-22-16-32-17-28-22/h2-10,12-14,16-17,24,27H,11,15H2,1H3,(H,29,30)/t24-/m0/s1
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n/an/an/an/a 810n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390598
PNG
(CHEMBL2069578)
Show SMILES COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 |r|
Show InChI InChI=1S/C25H24N4O2S/c1-31-24-8-7-20(14-22(24)19-9-11-26-12-10-19)29-25(30)23(13-18-5-3-2-4-6-18)27-15-21-16-32-17-28-21/h2-12,14,16-17,23,27H,13,15H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/an/an/a 980n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390596
PNG
(CHEMBL2069576)
Show SMILES COc1ccc(cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H24N4O2S/c1-31-24-8-7-20(19-9-11-26-12-10-19)14-22(24)29-25(30)23(13-18-5-3-2-4-6-18)27-15-21-16-32-17-28-21/h2-12,14,16-17,23,27H,13,15H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390581
PNG
(CHEMBL2069486)
Show SMILES NCC(=O)Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C12H12N4O2/c13-6-11(17)16-10-5-9(7-15-12(10)18)8-1-3-14-4-2-8/h1-5,7H,6,13H2,(H,15,18)(H,16,17)
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390584
PNG
(CHEMBL2069489)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H17ClN4O2/c20-15-3-1-12(2-4-15)9-16(21)18(25)24-17-10-14(11-23-19(17)26)13-5-7-22-8-6-13/h1-8,10-11,16H,9,21H2,(H,23,26)(H,24,25)/t16-/m0/s1
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n/an/an/an/a 3.80E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390593
PNG
(CHEMBL2069573)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C23H21N5O2S/c29-22-21(11-18(12-26-22)17-6-8-24-9-7-17)28-23(30)20(10-16-4-2-1-3-5-16)25-13-19-14-31-15-27-19/h1-9,11-12,14-15,20,25H,10,13H2,(H,26,29)(H,28,30)/t20-/m0/s1
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n/an/an/an/a 93n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390604
PNG
(CHEMBL2069584)
Show SMILES O=C(Nc1cccc(c1)-c1cc[nH]n1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C22H21N5OS/c28-22(26-18-8-4-7-17(12-18)20-9-10-25-27-20)21(11-16-5-2-1-3-6-16)23-13-19-14-29-15-24-19/h1-10,12,14-15,21,23H,11,13H2,(H,25,27)(H,26,28)/t21-/m0/s1
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n/an/an/an/a 67n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390593
PNG
(CHEMBL2069573)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C23H21N5O2S/c29-22-21(11-18(12-26-22)17-6-8-24-9-7-17)28-23(30)20(10-16-4-2-1-3-5-16)25-13-19-14-31-15-27-19/h1-9,11-12,14-15,20,25H,10,13H2,(H,26,29)(H,28,30)/t20-/m0/s1
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n/an/an/an/a 500n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390610
PNG
(CHEMBL2069590)
Show SMILES Cn1cc(cn1)-c1c[nH]c(=O)c(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C22H22N6O2S/c1-28-12-17(10-26-28)16-8-20(21(29)24-9-16)27-22(30)19(7-15-5-3-2-4-6-15)23-11-18-13-31-14-25-18/h2-6,8-10,12-14,19,23H,7,11H2,1H3,(H,24,29)(H,27,30)/t19-/m0/s1
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n/an/an/an/a 230n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390583
PNG
(CHEMBL2069488)
Show SMILES N[C@@H](Cc1cccc(Cl)c1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H17ClN4O2/c20-15-3-1-2-12(8-15)9-16(21)18(25)24-17-10-14(11-23-19(17)26)13-4-6-22-7-5-13/h1-8,10-11,16H,9,21H2,(H,23,26)(H,24,25)/t16-/m0/s1
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390590
PNG
(CHEMBL2069495)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C21H20N4O3/c1-14(26)24-18(11-15-5-3-2-4-6-15)21(28)25-19-12-17(13-23-20(19)27)16-7-9-22-10-8-16/h2-10,12-13,18H,11H2,1H3,(H,23,27)(H,24,26)(H,25,28)/t18-/m0/s1
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390609
PNG
(CHEMBL2069589)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1cc[nH]n1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C21H20N6O2S/c28-20-19(9-15(10-23-20)17-6-7-25-27-17)26-21(29)18(8-14-4-2-1-3-5-14)22-11-16-12-30-13-24-16/h1-7,9-10,12-13,18,22H,8,11H2,(H,23,28)(H,25,27)(H,26,29)/t18-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390611
PNG
(CHEMBL2069498)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCCc1ccccc1 |r|
Show InChI InChI=1S/C27H26N4O2/c32-26-25(18-23(19-30-26)22-12-14-28-15-13-22)31-27(33)24(17-21-9-5-2-6-10-21)29-16-11-20-7-3-1-4-8-20/h1-10,12-15,18-19,24,29H,11,16-17H2,(H,30,32)(H,31,33)/t24-/m0/s1
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n/an/an/an/a 780n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390580
PNG
(CHEMBL2069485)
Show SMILES N[C@@H](CC1CCCCC1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H24N4O2/c20-16(10-13-4-2-1-3-5-13)18(24)23-17-11-15(12-22-19(17)25)14-6-8-21-9-7-14/h6-9,11-13,16H,1-5,10,20H2,(H,22,25)(H,23,24)/t16-/m0/s1
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390586
PNG
(CHEMBL2069491)
Show SMILES N[C@@H](Cc1ccc(cc1)C#N)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C20H17N5O2/c21-11-14-3-1-13(2-4-14)9-17(22)19(26)25-18-10-16(12-24-20(18)27)15-5-7-23-8-6-15/h1-8,10,12,17H,9,22H2,(H,24,27)(H,25,26)/t17-/m0/s1
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n/an/an/an/a 4.60E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390588
PNG
(CHEMBL2069493)
Show SMILES COc1ccc(C[C@H](N)C(=O)Nc2cc(c[nH]c2=O)-c2ccncc2)cc1 |r|
Show InChI InChI=1S/C20H20N4O3/c1-27-16-4-2-13(3-5-16)10-17(21)19(25)24-18-11-15(12-23-20(18)26)14-6-8-22-9-7-14/h2-9,11-12,17H,10,21H2,1H3,(H,23,26)(H,24,25)/t17-/m0/s1
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n/an/an/an/a 2.50E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390597
PNG
(CHEMBL2069577)
Show SMILES COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H24N4O2S/c1-31-23-13-20(19-7-9-26-10-8-19)12-21(14-23)29-25(30)24(11-18-5-3-2-4-6-18)27-15-22-16-32-17-28-22/h2-10,12-14,16-17,24,27H,11,15H2,1H3,(H,29,30)/t24-/m0/s1
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n/an/an/an/a 53n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390606
PNG
(CHEMBL2069586)
Show SMILES O=C(Nc1cccc(c1)-c1cn[nH]c1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C22H21N5OS/c28-22(27-19-8-4-7-17(10-19)18-11-25-26-12-18)21(9-16-5-2-1-3-6-16)23-13-20-14-29-15-24-20/h1-8,10-12,14-15,21,23H,9,13H2,(H,25,26)(H,27,28)/t21-/m0/s1
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n/an/an/an/a 180n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390585
PNG
(CHEMBL2069490)
Show SMILES N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H17FN4O2/c20-15-3-1-12(2-4-15)9-16(21)18(25)24-17-10-14(11-23-19(17)26)13-5-7-22-8-6-13/h1-8,10-11,16H,9,21H2,(H,23,26)(H,24,25)/t16-/m0/s1
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n/an/an/an/a 4.20E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390592
PNG
(CHEMBL2069497)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1ccccc1 |r|
Show InChI InChI=1S/C26H24N4O2/c31-25-24(16-22(18-29-25)21-11-13-27-14-12-21)30-26(32)23(15-19-7-3-1-4-8-19)28-17-20-9-5-2-6-10-20/h1-14,16,18,23,28H,15,17H2,(H,29,31)(H,30,32)/t23-/m0/s1
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n/an/an/an/a 830n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390601
PNG
(CHEMBL2069581)
Show SMILES Cc1cc(ccn1)-c1cccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C25H24N4OS/c1-18-12-21(10-11-26-18)20-8-5-9-22(14-20)29-25(30)24(13-19-6-3-2-4-7-19)27-15-23-16-31-17-28-23/h2-12,14,16-17,24,27H,13,15H2,1H3,(H,29,30)/t24-/m0/s1
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n/an/an/an/a 52n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390608
PNG
(CHEMBL2069588)
Show SMILES Cc1cc(ccn1)-c1c[nH]c(=O)c(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C24H23N5O2S/c1-16-9-18(7-8-25-16)19-11-22(23(30)27-12-19)29-24(31)21(10-17-5-3-2-4-6-17)26-13-20-14-32-15-28-20/h2-9,11-12,14-15,21,26H,10,13H2,1H3,(H,27,30)(H,29,31)/t21-/m0/s1
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n/an/an/an/a 67n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390594
PNG
(CHEMBL2069574)
Show SMILES O=C(Nc1nccc(n1)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C22H20N6OS/c29-21(28-22-24-11-8-19(27-22)17-6-9-23-10-7-17)20(12-16-4-2-1-3-5-16)25-13-18-14-30-15-26-18/h1-11,14-15,20,25H,12-13H2,(H,24,27,28,29)/t20-/m0/s1
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n/an/an/an/a 290n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390595
PNG
(CHEMBL2069575)
Show SMILES O=C(Nc1cccc(c1)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C24H22N4OS/c29-24(28-21-8-4-7-20(14-21)19-9-11-25-12-10-19)23(13-18-5-2-1-3-6-18)26-15-22-16-30-17-27-22/h1-12,14,16-17,23,26H,13,15H2,(H,28,29)/t23-/m0/s1
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n/an/an/an/a 970n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390599
PNG
(CHEMBL2069579)
Show SMILES OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H22N4O3S/c30-24(23(10-17-4-2-1-3-5-17)27-14-22-15-33-16-28-22)29-21-12-19(11-20(13-21)25(31)32)18-6-8-26-9-7-18/h1-9,11-13,15-16,23,27H,10,14H2,(H,29,30)(H,31,32)/t23-/m0/s1
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n/an/an/an/a 480n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390579
PNG
(CHEMBL2069484)
Show SMILES N[C@H](C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1)c1ccccc1 |r|
Show InChI InChI=1S/C18H16N4O2/c19-16(13-4-2-1-3-5-13)18(24)22-15-10-14(11-21-17(15)23)12-6-8-20-9-7-12/h1-11,16H,19H2,(H,21,23)(H,22,24)/t16-/m0/s1
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390589
PNG
(CHEMBL2069494)
Show SMILES O=C(CCc1ccccc1)Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C19H17N3O2/c23-18(7-6-14-4-2-1-3-5-14)22-17-12-16(13-21-19(17)24)15-8-10-20-11-9-15/h1-5,8-13H,6-7H2,(H,21,24)(H,22,23)
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390595
PNG
(CHEMBL2069575)
Show SMILES O=C(Nc1cccc(c1)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C24H22N4OS/c29-24(28-21-8-4-7-20(14-21)19-9-11-25-12-10-19)23(13-18-5-2-1-3-6-18)26-15-22-16-30-17-27-22/h1-12,14,16-17,23,26H,13,15H2,(H,28,29)/t23-/m0/s1
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n/an/an/an/a 67n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390602
PNG
(CHEMBL2069582)
Show SMILES Nc1cc(ccn1)-c1cccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C24H23N5OS/c25-23-13-19(9-10-26-23)18-7-4-8-20(12-18)29-24(30)22(11-17-5-2-1-3-6-17)27-14-21-15-31-16-28-21/h1-10,12-13,15-16,22,27H,11,14H2,(H2,25,26)(H,29,30)/t22-/m0/s1
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n/an/an/an/a 210n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390577
PNG
(CHEMBL2069482)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H18N4O2/c20-16(10-13-4-2-1-3-5-13)18(24)23-17-11-15(12-22-19(17)25)14-6-8-21-9-7-14/h1-9,11-12,16H,10,20H2,(H,22,25)(H,23,24)/t16-/m0/s1
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n/an/an/an/a 4.80E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390608
PNG
(CHEMBL2069588)
Show SMILES Cc1cc(ccn1)-c1c[nH]c(=O)c(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r|
Show InChI InChI=1S/C24H23N5O2S/c1-16-9-18(7-8-25-16)19-11-22(23(30)27-12-19)29-24(31)21(10-17-5-3-2-4-6-17)26-13-20-14-32-15-28-20/h2-9,11-12,14-15,21,26H,10,13H2,1H3,(H,27,30)(H,29,31)/t21-/m0/s1
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n/an/an/an/a 290n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)		BDBM50390577
PNG
(CHEMBL2069482)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H18N4O2/c20-16(10-13-4-2-1-3-5-13)18(24)23-17-11-15(12-22-19(17)25)14-6-8-21-9-7-14/h1-9,11-12,16H,10,20H2,(H,22,25)(H,23,24)/t16-/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 assessed as inositol phosphate accumulation

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390600
PNG
(CHEMBL2069580)
Show SMILES O=C(Nc1ccccc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C19H19N3OS/c23-19(22-16-9-5-2-6-10-16)18(11-15-7-3-1-4-8-15)20-12-17-13-24-14-21-17/h1-10,13-14,18,20H,11-12H2,(H,22,23)/t18-/m0/s1
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n/an/an/an/a 3.30E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390582
PNG
(CHEMBL2069487)
Show SMILES N[C@@H](Cc1ccccc1Cl)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H17ClN4O2/c20-15-4-2-1-3-13(15)9-16(21)18(25)24-17-10-14(11-23-19(17)26)12-5-7-22-8-6-12/h1-8,10-11,16H,9,21H2,(H,23,26)(H,24,25)/t16-/m0/s1
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n/an/an/an/a>3.30E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390599
PNG
(CHEMBL2069579)
Show SMILES OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(c1)-c1ccncc1 |r|
Show InChI InChI=1S/C25H22N4O3S/c30-24(23(10-17-4-2-1-3-5-17)27-14-22-15-33-16-28-22)29-21-12-19(11-20(13-21)25(31)32)18-6-8-26-9-7-18/h1-9,11-13,15-16,23,27H,10,14H2,(H,29,30)(H,31,32)/t23-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation using [3H]-inositol after 1 hr by scintillatio...

Bioorg Med Chem Lett 22: 5942-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%