| Reaction Details |
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 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
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| Ligand | BDBM50390610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835424 (CHEMBL2072130) |
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| EC50 | 230±n/a nM |
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| Citation |  Lizarzaburu, M; Turcotte, S; Du, X; Duquette, J; Fu, A; Houze, J; Li, L; Liu, J; Murakoshi, M; Oda, K; Okuyama, R; Nara, F; Reagan, J; Yu, M; Medina, JC Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett22:5942-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Probable G-protein coupled receptor 142 |
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| Name: | Probable G-protein coupled receptor 142 |
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| Synonyms: | G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51127.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_985961 |
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| Residue: | 462 |
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| Sequence: | MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQ
VTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATA
GQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVA
LARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFA
ANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMW
RDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILL
GITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKT
FRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
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| BDBM50390610 |
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| n/a |
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| Name | BDBM50390610 |
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| Synonyms: | CHEMBL2069590 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N6O2S |
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| Mol. Mass. | 434.514 |
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| SMILES | Cn1cc(cn1)-c1c[nH]c(=O)c(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)c1 |r| |
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| Structure | 
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