Found 40 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434697
(CHEMBL2385195)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C39H33F4N5O5/c1-51-34-22-26-29(23-35(34)52-20-8-19-47-17-6-7-18-47)44-16-15-32(26)53-33-14-13-24(21-28(33)40)45-38(50)36-37(49)25-9-2-4-11-30(25)48(46-36)31-12-5-3-10-27(31)39(41,42)43/h2-5,9-16,21-23H,6-8,17-20H2,1H3,(H,45,50) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434730
(CHEMBL2385176)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C39H33F4N5O6/c1-51-34-22-26-29(23-35(34)53-18-6-15-47-16-19-52-20-17-47)44-14-13-32(26)54-33-12-11-24(21-28(33)40)45-38(50)36-37(49)25-7-2-4-9-30(25)48(46-36)31-10-5-3-8-27(31)39(41,42)43/h2-5,7-14,21-23H,6,15-20H2,1H3,(H,45,50) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50383191
(CHEMBL2031893)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC Show InChI InChI=1S/C29H25FN4O5/c1-17-27(29(36)34(33(17)2)19-8-6-5-7-9-19)28(35)32-18-10-11-24(21(30)14-18)39-23-12-13-31-22-16-26(38-4)25(37-3)15-20(22)23/h5-16H,1-4H3,(H,32,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434729
(CHEMBL2385175)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C38H33ClFN5O6/c1-48-34-22-26-29(23-35(34)50-18-6-15-44-16-19-49-20-17-44)41-14-13-32(26)51-33-12-11-24(21-28(33)40)42-38(47)36-37(46)25-7-2-4-9-30(25)45(43-36)31-10-5-3-8-27(31)39/h2-5,7-14,21-23H,6,15-20H2,1H3,(H,42,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
(FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434728
(CHEMBL2385202)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C40H35F4N5O5/c1-52-35-23-27-30(24-36(35)53-21-9-20-48-18-7-2-8-19-48)45-17-16-33(27)54-34-15-14-25(22-29(34)41)46-39(51)37-38(50)26-10-3-5-12-31(26)49(47-37)32-13-6-4-11-28(32)40(42,43)44/h3-6,10-17,22-24H,2,7-9,18-21H2,1H3,(H,46,51) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434727
(CHEMBL2385201)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H35ClFN5O5/c1-49-35-23-27-30(24-36(35)50-21-9-20-45-18-7-2-8-19-45)42-17-16-33(27)51-34-15-14-25(22-29(34)41)43-39(48)37-38(47)26-10-3-5-12-31(26)46(44-37)32-13-6-4-11-28(32)40/h3-6,10-17,22-24H,2,7-9,18-21H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434726
(CHEMBL2385188)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C40H37F2N5O5/c1-25-15-19-46(20-16-25)18-7-21-51-37-24-31-28(23-36(37)50-2)34(14-17-43-31)52-35-13-12-26(22-30(35)42)44-40(49)38-39(48)27-8-3-5-10-32(27)47(45-38)33-11-6-4-9-29(33)41/h3-6,8-14,17,22-25H,7,15-16,18-21H2,1-2H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434725
(CHEMBL2385205)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H35ClFN5O5/c1-49-35-23-29-31(24-36(35)50-21-7-20-45-18-5-2-6-19-45)42-17-16-33(29)51-34-15-12-26(22-30(34)41)43-39(48)37-38(47)28-8-3-4-9-32(28)46(44-37)27-13-10-25(40)11-14-27/h3-4,8-17,22-24H,2,5-7,18-21H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434724
(CHEMBL2385206)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Br)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H35BrFN5O5/c1-49-35-23-29-31(24-36(35)50-21-7-20-45-18-5-2-6-19-45)42-17-16-33(29)51-34-15-12-26(22-30(34)41)43-39(48)37-38(47)28-8-3-4-9-32(28)46(44-37)27-13-10-25(40)11-14-27/h3-4,8-17,22-24H,2,5-7,18-21H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434723
(CHEMBL2385203)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H35F2N5O5/c1-49-35-23-29-31(24-36(35)50-20-8-19-45-17-5-2-6-18-45)42-16-15-33(29)51-34-14-13-26(22-30(34)41)43-39(48)37-38(47)28-11-3-4-12-32(28)46(44-37)27-10-7-9-25(40)21-27/h3-4,7,9-16,21-24H,2,5-6,8,17-20H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434722
(CHEMBL2385204)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(c5)C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C40H35F4N5O5/c1-52-35-23-29-31(24-36(35)53-20-8-19-48-17-5-2-6-18-48)45-16-15-33(29)54-34-14-13-26(22-30(34)41)46-39(51)37-38(50)28-11-3-4-12-32(28)49(47-37)27-10-7-9-25(21-27)40(42,43)44/h3-4,7,9-16,21-24H,2,5-6,8,17-20H2,1H3,(H,46,51) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434721
(CHEMBL2385191)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C40H37F2N5O5/c1-25-15-19-46(20-16-25)18-5-21-51-37-24-32-30(23-36(37)50-2)34(14-17-43-32)52-35-13-10-27(22-31(35)42)44-40(49)38-39(48)29-6-3-4-7-33(29)47(45-38)28-11-8-26(41)9-12-28/h3-4,6-14,17,22-25H,5,15-16,18-21H2,1-2H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434720
(CHEMBL2385197)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)c(F)c5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H32F3N5O5/c1-49-34-21-26-30(22-35(34)50-18-6-17-45-15-4-5-16-45)42-14-13-32(26)51-33-12-9-23(19-29(33)41)43-38(48)36-37(47)25-7-2-3-8-31(25)46(44-36)24-10-11-27(39)28(40)20-24/h2-3,7-14,19-22H,4-6,15-18H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434719
(CHEMBL2385174)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C38H34FN5O6/c1-47-34-23-28-30(24-35(34)49-19-7-16-43-17-20-48-21-18-43)40-15-14-32(28)50-33-13-12-25(22-29(33)39)41-38(46)36-37(45)27-10-5-6-11-31(27)44(42-36)26-8-3-2-4-9-26/h2-6,8-15,22-24H,7,16-21H2,1H3,(H,41,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434718
(CHEMBL2385194)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)c(c5)C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C41H36ClF4N5O5/c1-24-13-17-50(18-14-24)16-5-19-55-37-23-32-28(22-36(37)54-2)34(12-15-47-32)56-35-11-8-25(20-31(35)43)48-40(53)38-39(52)27-6-3-4-7-33(27)51(49-38)26-9-10-30(42)29(21-26)41(44,45)46/h3-4,6-12,15,20-24H,5,13-14,16-19H2,1-2H3,(H,48,53) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434717
(CHEMBL2385199)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cc(ccc5Cl)C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C39H32ClF4N5O5/c1-52-34-21-26-29(22-35(34)53-18-6-17-48-15-4-5-16-48)45-14-13-32(26)54-33-12-10-24(20-28(33)41)46-38(51)36-37(50)25-7-2-3-8-30(25)49(47-36)31-19-23(39(42,43)44)9-11-27(31)40/h2-3,7-14,19-22H,4-6,15-18H2,1H3,(H,46,51) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434716
(CHEMBL2385177)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C39H33F4N5O7/c1-51-34-22-26-28(23-35(34)53-18-6-15-47-16-19-52-20-17-47)44-14-13-31(26)54-32-12-11-24(21-27(32)40)45-38(50)36-37(49)25-7-2-3-8-29(25)48(46-36)30-9-4-5-10-33(30)55-39(41,42)43/h2-5,7-14,21-23H,6,15-20H2,1H3,(H,45,50) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434715
(CHEMBL2385184)Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Nc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34FN5O5/c1-39-33(41)26(22-37-34(39)38-24-7-4-3-5-8-24)23-9-10-30(27(35)19-23)45-29-11-12-36-28-21-32(31(42-2)20-25(28)29)44-16-6-13-40-14-17-43-18-15-40/h3-5,7-12,19-22H,6,13-18H2,1-2H3,(H,37,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434713
(CHEMBL2385189)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Br)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C40H37BrFN5O5/c1-25-15-19-46(20-16-25)18-7-21-51-37-24-31-28(23-36(37)50-2)34(14-17-43-31)52-35-13-12-26(22-30(35)42)44-40(49)38-39(48)27-8-3-5-10-32(27)47(45-38)33-11-6-4-9-29(33)41/h3-6,8-14,17,22-25H,7,15-16,18-21H2,1-2H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434714
(CHEMBL2385190)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(c5)C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C41H37F4N5O5/c1-25-14-18-49(19-15-25)17-6-20-54-37-24-32-30(23-36(37)53-2)34(13-16-46-32)55-35-12-11-27(22-31(35)42)47-40(52)38-39(51)29-9-3-4-10-33(29)50(48-38)28-8-5-7-26(21-28)41(43,44)45/h3-5,7-13,16,21-25H,6,14-15,17-20H2,1-2H3,(H,47,52) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434712
(CHEMBL2385186)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 |(22.57,-52.86,;22.57,-54.4,;23.9,-55.17,;25.23,-54.4,;26.57,-55.16,;27.89,-54.39,;27.89,-52.85,;29.21,-52.07,;30.54,-52.84,;31.87,-52.07,;31.86,-50.52,;33.19,-49.75,;34.53,-50.51,;34.54,-52.05,;35.86,-49.73,;35.85,-48.19,;37.19,-47.42,;37.19,-45.88,;38.52,-45.09,;39.85,-45.86,;38.53,-43.55,;37.18,-42.81,;35.84,-43.59,;35.85,-45.12,;34.53,-45.9,;38.52,-48.18,;39.85,-47.4,;41.19,-48.17,;41.19,-49.73,;39.86,-50.5,;38.52,-49.73,;37.2,-50.5,;37.21,-52.04,;30.52,-49.76,;29.19,-50.54,;27.85,-49.79,;29.23,-55.15,;29.24,-56.7,;27.9,-57.47,;26.57,-56.71,;25.24,-57.48,;23.9,-56.71,;22.57,-57.48,;21.23,-56.71,;19.9,-57.48,;18.57,-56.71,;18.57,-55.17,;19.9,-54.4,;19.91,-52.87,;18.58,-52.09,;17.24,-52.86,;17.23,-54.4,)| Show InChI InChI=1S/C39H34Cl2FN5O5/c1-50-34-22-26-30(23-35(34)51-20-8-19-46-17-5-2-6-18-46)43-16-15-32(26)52-33-14-13-24(21-29(33)42)44-39(49)36-38(48)25-9-3-4-12-31(25)47(45-36)37-27(40)10-7-11-28(37)41/h3-4,7,9-16,21-23H,2,5-6,8,17-20H2,1H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434711
(CHEMBL2385193)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 |(48.04,-29.9,;48.04,-31.44,;49.37,-32.21,;50.7,-31.44,;52.04,-32.21,;53.36,-31.43,;53.36,-29.89,;54.68,-29.12,;56.01,-29.88,;57.34,-29.11,;57.33,-27.57,;58.66,-26.79,;60,-27.55,;60.01,-29.09,;61.33,-26.77,;61.32,-25.24,;62.66,-24.46,;62.66,-22.92,;61.32,-22.16,;60,-22.94,;61.31,-20.64,;62.65,-19.85,;64,-20.59,;63.99,-22.13,;65.33,-22.9,;63.99,-25.23,;65.32,-24.44,;66.66,-25.21,;66.67,-26.77,;65.33,-27.54,;63.99,-26.77,;62.67,-27.54,;62.68,-29.08,;55.99,-26.8,;54.66,-27.59,;53.32,-26.83,;54.7,-32.19,;54.71,-33.74,;53.37,-34.52,;52.04,-33.75,;50.71,-34.53,;49.37,-33.76,;48.04,-34.53,;46.7,-33.75,;45.37,-34.52,;44.04,-33.75,;44.04,-32.21,;45.37,-31.44,;45.38,-29.91,;44.05,-29.13,;44.06,-27.59,;42.71,-29.9,;42.7,-31.44,)| Show InChI InChI=1S/C40H36Cl2FN5O5/c1-24-14-18-47(19-15-24)17-6-20-52-36-23-31-27(22-35(36)51-2)33(13-16-44-31)53-34-12-11-25(21-30(34)43)45-40(50)37-39(49)26-7-3-4-10-32(26)48(46-37)38-28(41)8-5-9-29(38)42/h3-5,7-13,16,21-24H,6,14-15,17-20H2,1-2H3,(H,45,50) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434710
(CHEMBL2385198)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 |(22.1,-11.76,;22.1,-13.3,;23.43,-14.07,;24.76,-13.3,;26.09,-14.06,;27.42,-13.29,;27.41,-11.75,;28.74,-10.97,;30.07,-11.74,;31.4,-10.97,;31.39,-9.42,;32.72,-8.65,;34.06,-9.41,;34.07,-10.95,;35.39,-8.63,;35.38,-7.09,;36.71,-6.32,;36.71,-4.78,;35.38,-4.02,;34.05,-4.8,;35.37,-2.49,;36.71,-1.71,;38.06,-2.45,;38.05,-3.99,;39.38,-4.76,;38.05,-7.08,;39.38,-6.3,;40.71,-7.07,;40.72,-8.63,;39.38,-9.4,;38.05,-8.63,;36.73,-9.4,;36.74,-10.94,;30.05,-8.66,;28.72,-9.44,;27.38,-8.69,;28.76,-14.05,;28.77,-15.6,;27.43,-16.37,;26.1,-15.61,;24.76,-16.38,;23.43,-15.61,;22.09,-16.38,;20.76,-15.61,;19.43,-16.38,;18.09,-15.61,;18.1,-14.07,;19.34,-13.16,;18.87,-11.7,;17.33,-11.7,;16.85,-13.16,)| Show InChI InChI=1S/C38H32Cl2FN5O5/c1-49-33-21-25-29(22-34(33)50-19-7-18-45-16-4-5-17-45)42-15-14-31(25)51-32-13-12-23(20-28(32)41)43-38(48)35-37(47)24-8-2-3-11-30(24)46(44-35)36-26(39)9-6-10-27(36)40/h2-3,6,8-15,20-22H,4-5,7,16-19H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434709
(CHEMBL2385178)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(C)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C39H36FN5O6/c1-25-8-11-27(12-9-25)45-32-7-4-3-6-28(32)38(46)37(43-45)39(47)42-26-10-13-34(30(40)22-26)51-33-14-15-41-31-24-36(35(48-2)23-29(31)33)50-19-5-16-44-17-20-49-21-18-44/h3-4,6-15,22-24H,5,16-21H2,1-2H3,(H,42,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434708
(CHEMBL2385185)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)cc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H34Cl2FN5O5/c1-50-35-22-27-30(23-36(35)51-19-7-18-46-16-5-2-6-17-46)43-15-14-33(27)52-34-13-11-25(21-29(34)42)44-39(49)37-38(48)26-8-3-4-9-31(26)47(45-37)32-12-10-24(40)20-28(32)41/h3-4,8-15,20-23H,2,5-7,16-19H2,1H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50434697
(CHEMBL2385195)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C39H33F4N5O5/c1-51-34-22-26-29(23-35(34)52-20-8-19-47-17-6-7-18-47)44-16-15-32(26)53-33-14-13-24(21-28(33)40)45-38(50)36-37(49)25-9-2-4-11-30(25)48(46-36)31-12-5-3-10-27(31)39(41,42)43/h2-5,9-16,21-23H,6-8,17-20H2,1H3,(H,45,50) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Flt-3 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24751
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin...)Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C35H35FN4O5/c1-39-34(19-24-7-4-3-5-8-24)38-23-27(35(39)41)25-9-10-31(28(36)20-25)45-30-11-12-37-29-22-33(32(42-2)21-26(29)30)44-16-6-13-40-14-17-43-18-15-40/h3-5,7-12,20-23H,6,13-19H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of wild type GST-tagged c-Met kinase domain (1058 to 1365) (unknown origin) expressed in Sf9 cells by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434707
(CHEMBL2385179)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cc(C)ccc5C)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C40H38FN5O6/c1-25-9-10-26(2)33(21-25)46-32-8-5-4-7-28(32)39(47)38(44-46)40(48)43-27-11-12-35(30(41)22-27)52-34-13-14-42-31-24-37(36(49-3)23-29(31)34)51-18-6-15-45-16-19-50-20-17-45/h4-5,7-14,21-24H,6,15-20H2,1-3H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434706
(CHEMBL2385200)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cc(C)ccc5C)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C40H38FN5O5/c1-25-11-12-26(2)33(21-25)46-32-10-5-4-9-28(32)39(47)38(44-46)40(48)43-27-13-14-35(30(41)22-27)51-34-15-16-42-31-24-37(36(49-3)23-29(31)34)50-20-8-19-45-17-6-7-18-45/h4-5,9-16,21-24H,6-8,17-20H2,1-3H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434705
(CHEMBL2385196)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(c5)C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C39H33F4N5O5/c1-51-34-22-28-30(23-35(34)52-19-7-18-47-16-4-5-17-47)44-15-14-32(28)53-33-13-12-25(21-29(33)40)45-38(50)36-37(49)27-10-2-3-11-31(27)48(46-36)26-9-6-8-24(20-26)39(41,42)43/h2-3,6,8-15,20-23H,4-5,7,16-19H2,1H3,(H,45,50) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434704
(CHEMBL2385173)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5Br)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H32BrF2N5O5/c1-49-34-21-26-29(22-35(34)50-18-6-17-45-15-4-5-16-45)42-14-13-32(26)51-33-12-10-24(20-28(33)41)43-38(48)36-37(47)25-7-2-3-8-30(25)46(44-36)31-11-9-23(40)19-27(31)39/h2-3,7-14,19-22H,4-6,15-18H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434703
(CHEMBL2385187)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(C)cc5C)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C41H40FN5O5/c1-26-12-14-33(27(2)22-26)47-34-11-6-5-10-29(34)40(48)39(45-47)41(49)44-28-13-15-36(31(42)23-28)52-35-16-17-43-32-25-38(37(50-3)24-30(32)35)51-21-9-20-46-18-7-4-8-19-46/h5-6,10-17,22-25H,4,7-9,18-21H2,1-3H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434702
(CHEMBL2385192)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(C)cc5)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C41H40FN5O5/c1-26-9-12-29(13-10-26)47-34-8-5-4-7-30(34)40(48)39(45-47)41(49)44-28-11-14-36(32(42)23-28)52-35-15-18-43-33-25-38(37(50-3)24-31(33)35)51-22-6-19-46-20-16-27(2)17-21-46/h4-5,7-15,18,23-25,27H,6,16-17,19-22H2,1-3H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434700
(CHEMBL2385181)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c5cc(F)ccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H34ClF2N5O5/c1-50-35-22-27-30(23-36(35)51-19-7-18-46-16-5-2-6-17-46)43-15-14-33(27)52-34-13-11-25(21-29(34)42)44-39(49)37-38(48)26-12-10-24(41)20-32(26)47(45-37)31-9-4-3-8-28(31)40/h3-4,8-15,20-23H,2,5-7,16-19H2,1H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434701
(CHEMBL2385183)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c5cc(F)ccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C40H36ClF2N5O5/c1-24-13-17-47(18-14-24)16-5-19-52-37-23-31-28(22-36(37)51-2)34(12-15-44-31)53-35-11-9-26(21-30(35)43)45-40(50)38-39(49)27-10-8-25(42)20-33(27)48(46-38)32-7-4-3-6-29(32)41/h3-4,6-12,15,20-24H,5,13-14,16-19H2,1-2H3,(H,45,50) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434699
(CHEMBL2385180)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c5cc(F)ccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H34F3N5O5/c1-50-35-22-27-30(23-36(35)51-19-7-18-46-16-5-2-6-17-46)43-15-14-33(27)52-34-13-11-25(21-29(34)42)44-39(49)37-38(48)26-12-10-24(40)20-32(26)47(45-37)31-9-4-3-8-28(31)41/h3-4,8-15,20-23H,2,5-7,16-19H2,1H3,(H,44,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50434698
(CHEMBL2385182)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c5cc(F)ccc5c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C38H32F3N5O6/c1-49-34-21-26-29(22-35(34)51-16-4-13-45-14-17-50-18-15-45)42-12-11-32(26)52-33-10-8-24(20-28(33)41)43-38(48)36-37(47)25-9-7-23(39)19-31(25)46(44-36)30-6-3-2-5-27(30)40/h2-3,5-12,19-22H,4,13-18H2,1H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50434697
(CHEMBL2385195)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C39H33F4N5O5/c1-51-34-22-26-29(23-35(34)52-20-8-19-47-17-6-7-18-47)44-16-15-32(26)53-33-14-13-24(21-28(33)40)45-38(50)36-37(49)25-9-2-4-11-30(25)48(46-36)31-12-5-3-10-27(31)39(41,42)43/h2-5,9-16,21-23H,6-8,17-20H2,1H3,(H,45,50) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299767
(CHEMBL574125 | N-(3-fluoro-4-(6-methoxy-7-(3-morph...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H34FN5O6/c1-42-30-21-25-27(22-31(30)44-17-5-12-37-15-18-43-19-16-37)35-11-10-28(25)45-29-9-8-23(20-26(29)34)36-32(40)39-14-13-38(33(39)41)24-6-3-2-4-7-24/h2-4,6-11,20-22H,5,12-19H2,1H3,(H,36,40) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem 21: 2843-55 (2013)
Article DOI: 10.1016/j.bmc.2013.04.013
BindingDB Entry DOI: 10.7270/Q25D8T6Z |
More data for this
Ligand-Target Pair | |
Search and Browse
