BDBM50434710 CHEMBL2385198

SMILES: COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1

InChI Key: InChIKey=YXHJZCCPKMMPDW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50434710   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50434710 (CHEMBL2385198) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 |(22.1,-11.76,;22.1,-13.3,;23.43,-14.07,;24.76,-13.3,;26.09,-14.06,;27.42,-13.29,;27.41,-11.75,;28.74,-10.97,;30.07,-11.74,;31.4,-10.97,;31.39,-9.42,;32.72,-8.65,;34.06,-9.41,;34.07,-10.95,;35.39,-8.63,;35.38,-7.09,;36.71,-6.32,;36.71,-4.78,;35.38,-4.02,;34.05,-4.8,;35.37,-2.49,;36.71,-1.71,;38.06,-2.45,;38.05,-3.99,;39.38,-4.76,;38.05,-7.08,;39.38,-6.3,;40.71,-7.07,;40.72,-8.63,;39.38,-9.4,;38.05,-8.63,;36.73,-9.4,;36.74,-10.94,;30.05,-8.66,;28.72,-9.44,;27.38,-8.69,;28.76,-14.05,;28.77,-15.6,;27.43,-16.37,;26.1,-15.61,;24.76,-16.38,;23.43,-15.61,;22.09,-16.38,;20.76,-15.61,;19.43,-16.38,;18.09,-15.61,;18.1,-14.07,;19.34,-13.16,;18.87,-11.7,;17.33,-11.7,;16.85,-13.16,)| Show InChI InChI=1S/C38H32Cl2FN5O5/c1-49-33-21-25-29(22-34(33)50-19-7-18-45-16-4-5-17-45)42-15-14-31(25)51-32-13-12-23(20-28(32)41)43-38(48)35-37(47)24-8-2-3-11-30(24)46(44-35)36-26(39)9-6-10-27(36)40/h2-3,6,8-15,20-22H,4-5,7,16-19H2,1H3,(H,43,48)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay				Bioorg Med Chem 21: 2843-55 (2013) Article DOI: 10.1016/j.bmc.2013.04.013 BindingDB Entry DOI: 10.7270/Q25D8T6Z
					More data for this Ligand-Target Pair