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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Hepatocyte growth factor receptor | ||
| Ligand | BDBM50434710 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_961885 (CHEMBL2390327) | ||
| IC50 | 6.7±n/a nM | ||
| Citation |  Li, S; Zhao, Y; Wang, K; Gao, Y; Han, J; Cui, B; Gong, P Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors. Bioorg Med Chem21:2843-55 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Hepatocyte growth factor receptor | |||
| Name: | Hepatocyte growth factor receptor | ||
| Synonyms: | Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 155559.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08581 | ||
| Residue: | 1390 | ||
| Sequence: |
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| BDBM50434710 | |||
| n/a | |||
| Name | BDBM50434710 | ||
| Synonyms: | CHEMBL2385198 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C38H32Cl2FN5O5 | ||
| Mol. Mass. | 728.596 | ||
| SMILES | COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 |(22.1,-11.76,;22.1,-13.3,;23.43,-14.07,;24.76,-13.3,;26.09,-14.06,;27.42,-13.29,;27.41,-11.75,;28.74,-10.97,;30.07,-11.74,;31.4,-10.97,;31.39,-9.42,;32.72,-8.65,;34.06,-9.41,;34.07,-10.95,;35.39,-8.63,;35.38,-7.09,;36.71,-6.32,;36.71,-4.78,;35.38,-4.02,;34.05,-4.8,;35.37,-2.49,;36.71,-1.71,;38.06,-2.45,;38.05,-3.99,;39.38,-4.76,;38.05,-7.08,;39.38,-6.3,;40.71,-7.07,;40.72,-8.63,;39.38,-9.4,;38.05,-8.63,;36.73,-9.4,;36.74,-10.94,;30.05,-8.66,;28.72,-9.44,;27.38,-8.69,;28.76,-14.05,;28.77,-15.6,;27.43,-16.37,;26.1,-15.61,;24.76,-16.38,;23.43,-15.61,;22.09,-16.38,;20.76,-15.61,;19.43,-16.38,;18.09,-15.61,;18.1,-14.07,;19.34,-13.16,;18.87,-11.7,;17.33,-11.7,;16.85,-13.16,)| | ||
| Structure | 
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