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PubMed code 23719288

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Chymase


(Homo sapiens (Human))		BDBM100750
PNG
(CHEMBL2397003 | US8507714, 239)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1nnn[nH]1 |r|
Show InChI InChI=1S/C19H23ClN8O5/c1-3-13(16(30)23-18-24-26-27-25-18)22-19(32)28-9-15(29)21-8-11(17(28)31)6-10-7-12(20)4-5-14(10)33-2/h4-5,7,11,13H,3,6,8-9H2,1-2H3,(H,21,29)(H,22,32)(H2,23,24,25,26,27,30)/t11?,13-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50210730
PNG
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436403
PNG
(CHEMBL2397001)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cc(N)cc(c1)C(O)=O |r|
Show InChI InChI=1S/C25H28ClN5O7/c1-3-19(22(33)29-18-9-14(24(35)36)8-17(27)10-18)30-25(37)31-12-21(32)28-11-15(23(31)34)6-13-7-16(26)4-5-20(13)38-2/h4-5,7-10,15,19H,3,6,11-12,27H2,1-2H3,(H,28,32)(H,29,33)(H,30,37)(H,35,36)/t15?,19-/m1/s1
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n/an/a 380n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436400
PNG
(CHEMBL2397008)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cc(co1)C(O)=O |r|
Show InChI InChI=1S/C22H24ClN3O7/c1-3-16(18-8-14(11-33-18)21(29)30)25-22(31)26-10-19(27)24-9-13(20(26)28)6-12-7-15(23)4-5-17(12)32-2/h4-5,7-8,11,13,16H,3,6,9-10H2,1-2H3,(H,24,27)(H,25,31)(H,29,30)/t13-,16-/m1/s1
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n/an/a 380n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436399
PNG
(CHEMBL2397009)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1nc(co1)C(O)=O |r|
Show InChI InChI=1S/C21H23ClN4O7/c1-3-14(18-24-15(10-33-18)20(29)30)25-21(31)26-9-17(27)23-8-12(19(26)28)6-11-7-13(22)4-5-16(11)32-2/h4-5,7,10,12,14H,3,6,8-9H2,1-2H3,(H,23,27)(H,25,31)(H,29,30)/t12-,14-/m1/s1
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n/an/a 410n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436419
PNG
(CHEMBL2397011)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(o1)C(O)=O |r|
Show InChI InChI=1S/C22H24ClN3O7/c1-3-15(17-6-7-18(33-17)21(29)30)25-22(31)26-11-19(27)24-10-13(20(26)28)8-12-9-14(23)4-5-16(12)32-2/h4-7,9,13,15H,3,8,10-11H2,1-2H3,(H,24,27)(H,25,31)(H,29,30)/t13-,15-/m1/s1
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n/an/a 520n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436398
PNG
(CHEMBL2396929)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(c1)C(O)=O |r|
Show InChI InChI=1S/C25H27ClN4O7/c1-3-19(22(32)28-18-6-4-5-14(11-18)24(34)35)29-25(36)30-13-21(31)27-12-16(23(30)33)9-15-10-17(26)7-8-20(15)37-2/h4-8,10-11,16,19H,3,9,12-13H2,1-2H3,(H,27,31)(H,28,32)(H,29,36)(H,34,35)/t16?,19-/m1/s1
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n/an/a 570n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436404
PNG
(CHEMBL2397000)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccc(O)c(c1)C(O)=O |r|
Show InChI InChI=1S/C25H27ClN4O8/c1-3-18(22(33)28-16-5-6-19(31)17(10-16)24(35)36)29-25(37)30-12-21(32)27-11-14(23(30)34)8-13-9-15(26)4-7-20(13)38-2/h4-7,9-10,14,18,31H,3,8,11-12H2,1-2H3,(H,27,32)(H,28,33)(H,29,37)(H,35,36)/t14?,18-/m1/s1
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n/an/a 570n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436397
PNG
(CHEMBL2396997)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(N)c1 |r|
Show InChI InChI=1S/C24H28ClN5O5/c1-3-19(22(32)28-18-6-4-5-17(26)11-18)29-24(34)30-13-21(31)27-12-15(23(30)33)9-14-10-16(25)7-8-20(14)35-2/h4-8,10-11,15,19H,3,9,12-13,26H2,1-2H3,(H,27,31)(H,28,32)(H,29,34)/t15?,19-/m1/s1
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n/an/a 660n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436405
PNG
(CHEMBL2396999)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccc(N)c(c1)C(O)=O |r|
Show InChI InChI=1S/C25H28ClN5O7/c1-3-19(22(33)29-16-5-6-18(27)17(10-16)24(35)36)30-25(37)31-12-21(32)28-11-14(23(31)34)8-13-9-15(26)4-7-20(13)38-2/h4-7,9-10,14,19H,3,8,11-12,27H2,1-2H3,(H,28,32)(H,29,33)(H,30,37)(H,35,36)/t14?,19-/m1/s1
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n/an/a 730n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436407
PNG
(CHEMBL2396996)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C25H27ClN4O7/c1-3-19(22(32)28-18-7-4-14(5-8-18)24(34)35)29-25(36)30-13-21(31)27-12-16(23(30)33)10-15-11-17(26)6-9-20(15)37-2/h4-9,11,16,19H,3,10,12-13H2,1-2H3,(H,27,31)(H,28,32)(H,29,36)(H,34,35)/t16?,19-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436406
PNG
(CHEMBL2396998)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccc(N)cc1 |r|
Show InChI InChI=1S/C24H28ClN5O5/c1-3-19(22(32)28-18-7-5-17(26)6-8-18)29-24(34)30-13-21(31)27-12-15(23(30)33)10-14-11-16(25)4-9-20(14)35-2/h4-9,11,15,19H,3,10,12-13,26H2,1-2H3,(H,27,31)(H,28,32)(H,29,34)/t15?,19-/m1/s1
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n/an/a 790n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436402
PNG
(CHEMBL2397002)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1c[nH]c(c1)C(O)=O |r|
Show InChI InChI=1S/C23H26ClN5O7/c1-3-16(20(31)27-15-8-17(22(33)34)25-10-15)28-23(35)29-11-19(30)26-9-13(21(29)32)6-12-7-14(24)4-5-18(12)36-2/h4-5,7-8,10,13,16,25H,3,6,9,11H2,1-2H3,(H,26,30)(H,27,31)(H,28,35)(H,33,34)/t13?,16-/m1/s1
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n/an/a 850n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436422
PNG
(CHEMBL2397006)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(cn1)C(O)=O |r|
Show InChI InChI=1S/C23H25ClN4O6/c1-3-17(18-6-4-13(10-25-18)22(31)32)27-23(33)28-12-20(29)26-11-15(21(28)30)8-14-9-16(24)5-7-19(14)34-2/h4-7,9-10,15,17H,3,8,11-12H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t15-,17-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436420
PNG
(CHEMBL2397010)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cc(ccn1)C(O)=O |r|
Show InChI InChI=1S/C23H25ClN4O6/c1-3-17(18-10-13(22(31)32)6-7-25-18)27-23(33)28-12-20(29)26-11-15(21(28)30)8-14-9-16(24)4-5-19(14)34-2/h4-7,9-10,15,17H,3,8,11-12H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t15-,17-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM100747
PNG
(CHEMBL2397007 | US8507714, 151)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cncc(c1)C(O)=O |r|
Show InChI InChI=1S/C23H25ClN4O6/c1-3-18(14-7-16(22(31)32)10-25-9-14)27-23(33)28-12-20(29)26-11-15(21(28)30)6-13-8-17(24)4-5-19(13)34-2/h4-5,7-10,15,18H,3,6,11-12H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t15-,18-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436412
PNG
(CHEMBL2396924)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C24H27ClN4O5/c1-3-19(22(31)27-18-7-5-4-6-8-18)28-24(33)29-14-21(30)26-13-16(23(29)32)11-15-12-17(25)9-10-20(15)34-2/h4-10,12,16,19H,3,11,13-14H2,1-2H3,(H,26,30)(H,27,31)(H,28,33)/t16?,19-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436417
PNG
(CHEMBL2396919)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C21H23ClN4O6S/c1-3-14(18-24-15(10-33-18)20(29)30)25-21(31)26-9-17(27)23-8-12(19(26)28)6-11-7-13(22)4-5-16(11)32-2/h4-5,7,10,12,14H,3,6,8-9H2,1-2H3,(H,23,27)(H,25,31)(H,29,30)/t12-,14-/m1/s1
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n/an/a 1.64E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436409
PNG
(CHEMBL2396927)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccncc1 |r|
Show InChI InChI=1S/C23H26ClN5O5/c1-3-18(21(31)27-17-6-8-25-9-7-17)28-23(33)29-13-20(30)26-12-15(22(29)32)10-14-11-16(24)4-5-19(14)34-2/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,26,30)(H,28,33)(H,25,27,31)/t15?,18-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436414
PNG
(CHEMBL2396922)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)N[C@@H](C)C(O)=O |r|
Show InChI InChI=1S/C21H27ClN4O7/c1-4-15(18(28)24-11(2)20(30)31)25-21(32)26-10-17(27)23-9-13(19(26)29)7-12-8-14(22)5-6-16(12)33-3/h5-6,8,11,13,15H,4,7,9-10H2,1-3H3,(H,23,27)(H,24,28)(H,25,32)(H,30,31)/t11-,13?,15+/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436418
PNG
(CHEMBL2397012)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cc(cs1)C(O)=O |r|
Show InChI InChI=1S/C22H24ClN3O6S/c1-3-16(18-8-14(11-33-18)21(29)30)25-22(31)26-10-19(27)24-9-13(20(26)28)6-12-7-15(23)4-5-17(12)32-2/h4-5,7-8,11,13,16H,3,6,9-10H2,1-2H3,(H,24,27)(H,25,31)(H,29,30)/t13-,16-/m1/s1
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n/an/a 2.77E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436411
PNG
(CHEMBL2396925)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccccn1 |r|
Show InChI InChI=1S/C23H26ClN5O5/c1-3-17(21(31)28-19-6-4-5-9-25-19)27-23(33)29-13-20(30)26-12-15(22(29)32)10-14-11-16(24)7-8-18(14)34-2/h4-9,11,15,17H,3,10,12-13H2,1-2H3,(H,26,30)(H,27,33)(H,25,28,31)/t15?,17-/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436413
PNG
(CHEMBL2396923)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)N[C@H](C)C(O)=O |r|
Show InChI InChI=1S/C21H27ClN4O7/c1-4-15(18(28)24-11(2)20(30)31)25-21(32)26-10-17(27)23-9-13(19(26)29)7-12-8-14(22)5-6-16(12)33-3/h5-6,8,11,13,15H,4,7,9-10H2,1-3H3,(H,23,27)(H,24,28)(H,25,32)(H,30,31)/t11-,13?,15-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436410
PNG
(CHEMBL2396926)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccnc1 |r|
Show InChI InChI=1S/C23H26ClN5O5/c1-3-18(21(31)27-17-5-4-8-25-12-17)28-23(33)29-13-20(30)26-11-15(22(29)32)9-14-10-16(24)6-7-19(14)34-2/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,26,30)(H,27,31)(H,28,33)/t15?,18-/m1/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436408
PNG
(CHEMBL2396928)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccccc1C(O)=O |r|
Show InChI InChI=1S/C25H27ClN4O7/c1-3-18(22(32)28-19-7-5-4-6-17(19)24(34)35)29-25(36)30-13-21(31)27-12-15(23(30)33)10-14-11-16(26)8-9-20(14)37-2/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,27,31)(H,28,32)(H,29,36)(H,34,35)/t15?,18-/m1/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436401
PNG
(CHEMBL2397005)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)C(O)=O |r|
Show InChI InChI=1S/C18H22ClN3O6/c1-3-13(17(25)26)21-18(27)22-9-15(23)20-8-11(16(22)24)6-10-7-12(19)4-5-14(10)28-2/h4-5,7,11,13H,3,6,8-9H2,1-2H3,(H,20,23)(H,21,27)(H,25,26)/t11-,13-/m1/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436415
PNG
(CHEMBL2396921)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(O)=O |r|
Show InChI InChI=1S/C20H25ClN4O7/c1-3-14(18(29)23-9-17(27)28)24-20(31)25-10-16(26)22-8-12(19(25)30)6-11-7-13(21)4-5-15(11)32-2/h4-5,7,12,14H,3,6,8-10H2,1-2H3,(H,22,26)(H,23,29)(H,24,31)(H,27,28)/t12?,14-/m1/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436416
PNG
(CHEMBL2396920)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NC |r|
Show InChI InChI=1S/C19H25ClN4O5/c1-4-14(17(26)21-2)23-19(28)24-10-16(25)22-9-12(18(24)27)7-11-8-13(20)5-6-15(11)29-3/h5-6,8,12,14H,4,7,9-10H2,1-3H3,(H,21,26)(H,22,25)(H,23,28)/t12?,14-/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50436400
PNG
(CHEMBL2397008)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cc(co1)C(O)=O |r|
Show InChI InChI=1S/C22H24ClN3O7/c1-3-16(18-8-14(11-33-18)21(29)30)25-22(31)26-10-19(27)24-9-13(20(26)28)6-12-7-15(23)4-5-17(12)32-2/h4-5,7-8,11,13,16H,3,6,9-10H2,1-2H3,(H,24,27)(H,25,31)(H,29,30)/t13-,16-/m1/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50436398
PNG
(CHEMBL2396929)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(c1)C(O)=O |r|
Show InChI InChI=1S/C25H27ClN4O7/c1-3-19(22(32)28-18-6-4-5-14(11-18)24(34)35)29-25(36)30-13-21(31)27-12-16(23(30)33)9-15-10-17(26)7-8-20(15)37-2/h4-8,10-11,16,19H,3,9,12-13H2,1-2H3,(H,27,31)(H,28,32)(H,29,36)(H,34,35)/t16?,19-/m1/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))		BDBM50436401
PNG
(CHEMBL2397005)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)C(O)=O |r|
Show InChI InChI=1S/C18H22ClN3O6/c1-3-13(17(25)26)21-18(27)22-9-15(23)20-8-11(16(22)24)6-10-7-12(19)4-5-14(10)28-2/h4-5,7,11,13H,3,6,8-9H2,1-2H3,(H,20,23)(H,21,27)(H,25,26)/t11-,13-/m1/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50436397
PNG
(CHEMBL2396997)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(N)c1 |r|
Show InChI InChI=1S/C24H28ClN5O5/c1-3-19(22(32)28-18-6-4-5-17(26)11-18)29-24(34)30-13-21(31)27-12-15(23(30)33)9-14-10-16(25)7-8-20(14)35-2/h4-8,10-11,15,19H,3,9,12-13,26H2,1-2H3,(H,27,31)(H,28,32)(H,29,34)/t15?,19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Neutrophil elastase


(Homo sapiens (Human))		BDBM50436398
PNG
(CHEMBL2396929)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(c1)C(O)=O |r|
Show InChI InChI=1S/C25H27ClN4O7/c1-3-19(22(32)28-18-6-4-5-14(11-18)24(34)35)29-25(36)30-13-21(31)27-12-16(23(30)33)9-15-10-17(26)7-8-20(15)37-2/h4-8,10-11,16,19H,3,9,12-13H2,1-2H3,(H,27,31)(H,28,32)(H,29,36)(H,34,35)/t16?,19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Neutrophil elastase


(Homo sapiens (Human))		BDBM100750
PNG
(CHEMBL2397003 | US8507714, 239)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1nnn[nH]1 |r|
Show InChI InChI=1S/C19H23ClN8O5/c1-3-13(16(30)23-18-24-26-27-25-18)22-19(32)28-9-15(29)21-8-11(17(28)31)6-10-7-12(20)4-5-14(10)33-2/h4-5,7,11,13H,3,6,8-9H2,1-2H3,(H,21,29)(H,22,32)(H2,23,24,25,26,27,30)/t11?,13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM100750
PNG
(CHEMBL2397003 | US8507714, 239)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1nnn[nH]1 |r|
Show InChI InChI=1S/C19H23ClN8O5/c1-3-13(16(30)23-18-24-26-27-25-18)22-19(32)28-9-15(29)21-8-11(17(28)31)6-10-7-12(20)4-5-14(10)33-2/h4-5,7,11,13H,3,6,8-9H2,1-2H3,(H,21,29)(H,22,32)(H2,23,24,25,26,27,30)/t11?,13-/m1/s1
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Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Neutrophil elastase


(Homo sapiens (Human))		BDBM50436397
PNG
(CHEMBL2396997)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(N)c1 |r|
Show InChI InChI=1S/C24H28ClN5O5/c1-3-19(22(32)28-18-6-4-5-17(26)11-18)29-24(34)30-13-21(31)27-12-15(23(30)33)9-14-10-16(25)7-8-20(14)35-2/h4-8,10-11,15,19H,3,9,12-13,26H2,1-2H3,(H,27,31)(H,28,32)(H,29,34)/t15?,19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50210730
PNG
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19-/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50436399
PNG
(CHEMBL2397009)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1nc(co1)C(O)=O |r|
Show InChI InChI=1S/C21H23ClN4O7/c1-3-14(18-24-15(10-33-18)20(29)30)25-21(31)26-9-17(27)23-8-12(19(26)28)6-11-7-13(22)4-5-16(11)32-2/h4-5,7,10,12,14H,3,6,8-9H2,1-2H3,(H,23,27)(H,25,31)(H,29,30)/t12-,14-/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Neutrophil elastase


(Homo sapiens (Human))		BDBM50436400
PNG
(CHEMBL2397008)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cc(co1)C(O)=O |r|
Show InChI InChI=1S/C22H24ClN3O7/c1-3-16(18-8-14(11-33-18)21(29)30)25-22(31)26-10-19(27)24-9-13(20(26)28)6-12-7-15(23)4-5-17(12)32-2/h4-5,7-8,11,13,16H,3,6,9-10H2,1-2H3,(H,24,27)(H,25,31)(H,29,30)/t13-,16-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Neutrophil elastase


(Homo sapiens (Human))		BDBM50436399
PNG
(CHEMBL2397009)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1nc(co1)C(O)=O |r|
Show InChI InChI=1S/C21H23ClN4O7/c1-3-14(18-24-15(10-33-18)20(29)30)25-21(31)26-9-17(27)23-8-12(19(26)28)6-11-7-13(22)4-5-16(11)32-2/h4-5,7,10,12,14H,3,6,8-9H2,1-2H3,(H,23,27)(H,25,31)(H,29,30)/t12-,14-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
Neutrophil elastase


(Homo sapiens (Human))		BDBM50210730
PNG
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19-/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...

Bioorg Med Chem 21: 4233-49 (2013)


Article DOI: 10.1016/j.bmc.2013.04.079
BindingDB Entry DOI: 10.7270/Q2CF9RHR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%