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PubMed code 23845217

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50334594
PNG
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)
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n/an/a 7n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438048
PNG
(CHEMBL2409592)
Show SMILES CNC(=O)c1ccccc1Nc1ncnc(Nc2ccc(CN)cc2)n1
Show InChI InChI=1S/C18H19N7O/c1-20-16(26)14-4-2-3-5-15(14)24-18-22-11-21-17(25-18)23-13-8-6-12(10-19)7-9-13/h2-9,11H,10,19H2,1H3,(H,20,26)(H2,21,22,23,24,25)
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n/an/a 160n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438050
PNG
(CHEMBL2409590)
Show SMILES CNC(=O)c1ccccc1Nc1ncnc(Nc2cc(CCC(N)=O)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C22H25N7O4/c1-24-20(31)15-6-4-5-7-16(15)28-22-26-12-25-21(29-22)27-14-10-13(8-9-18(23)30)19(33-3)17(11-14)32-2/h4-7,10-12H,8-9H2,1-3H3,(H2,23,30)(H,24,31)(H2,25,26,27,28,29)
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n/an/a 300n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438051
PNG
(CHEMBL2409589)
Show SMILES CNC(=O)c1ccccc1Nc1ncnc(Nc2ccc(cc2OC)N2CCOCC2)n1
Show InChI InChI=1S/C22H25N7O3/c1-23-20(30)16-5-3-4-6-17(16)26-21-24-14-25-22(28-21)27-18-8-7-15(13-19(18)31-2)29-9-11-32-12-10-29/h3-8,13-14H,9-12H2,1-2H3,(H,23,30)(H2,24,25,26,27,28)
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n/an/a 320n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438033
PNG
(CHEMBL2409605)
Show SMILES CNC(=O)c1ccccc1Nc1ncnc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C20H22N6O4/c1-21-18(27)13-7-5-6-8-14(13)25-20-23-11-22-19(26-20)24-12-9-15(28-2)17(30-4)16(10-12)29-3/h5-11H,1-4H3,(H,21,27)(H2,22,23,24,25,26)
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n/an/a 400n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438047
PNG
(CHEMBL2409593)
Show SMILES CCNC(=O)c1ccccc1Nc1ncnc(Nc2ccc(CN)cc2)n1
Show InChI InChI=1S/C19H21N7O/c1-2-21-17(27)15-5-3-4-6-16(15)25-19-23-12-22-18(26-19)24-14-9-7-13(11-20)8-10-14/h3-10,12H,2,11,20H2,1H3,(H,21,27)(H2,22,23,24,25,26)
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n/an/a 440n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438046
PNG
(CHEMBL2409577)
Show SMILES CC(C)NC(=O)c1ccccc1Nc1ncnc(Nc2ccc(CN)cc2)n1
Show InChI InChI=1S/C20H23N7O/c1-13(2)24-18(28)16-5-3-4-6-17(16)26-20-23-12-22-19(27-20)25-15-9-7-14(11-21)8-10-15/h3-10,12-13H,11,21H2,1-2H3,(H,24,28)(H2,22,23,25,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438053
PNG
(CHEMBL2409587)
Show SMILES CNC(=O)c1ccccc1Nc1ncnc(Nc2ccc(OC)cc2OC)n1
Show InChI InChI=1S/C19H20N6O3/c1-20-17(26)13-6-4-5-7-14(13)23-18-21-11-22-19(25-18)24-15-9-8-12(27-2)10-16(15)28-3/h4-11H,1-3H3,(H,20,26)(H2,21,22,23,24,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438045
PNG
(CHEMBL2409578)
Show SMILES CCC(CC)NC(=O)c1ccccc1Nc1ncnc(Nc2ccc(CN)cc2)n1
Show InChI InChI=1S/C22H27N7O/c1-3-16(4-2)26-20(30)18-7-5-6-8-19(18)28-22-25-14-24-21(29-22)27-17-11-9-15(13-23)10-12-17/h5-12,14,16H,3-4,13,23H2,1-2H3,(H,26,30)(H2,24,25,27,28,29)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438061
PNG
(CHEMBL2409579)
Show SMILES COc1cc(Nc2ncnc(Nc3ccccc3C(=O)NC(C)C)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H26N6O4/c1-13(2)25-20(29)15-8-6-7-9-16(15)27-22-24-12-23-21(28-22)26-14-10-17(30-3)19(32-5)18(11-14)31-4/h6-13H,1-5H3,(H,25,29)(H2,23,24,26,27,28)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438049
PNG
(CHEMBL2409591)
Show SMILES CS(=O)(=O)Nc1ccccc1Nc1ncnc(Nc2ccc(CN)cc2)n1
Show InChI InChI=1S/C17H19N7O2S/c1-27(25,26)24-15-5-3-2-4-14(15)22-17-20-11-19-16(23-17)21-13-8-6-12(10-18)7-9-13/h2-9,11,24H,10,18H2,1H3,(H2,19,20,21,22,23)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438043
PNG
(CHEMBL2409595)
Show SMILES COc1cc(Nc2ncnc(Nc3ccccc3NS(C)(=O)=O)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H22N6O5S/c1-28-15-9-12(10-16(29-2)17(15)30-3)22-18-20-11-21-19(24-18)23-13-7-5-6-8-14(13)25-31(4,26)27/h5-11,25H,1-4H3,(H2,20,21,22,23,24)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438058
PNG
(CHEMBL2409582)
Show SMILES COc1cc(Nc2ncnc(Nc3ccccc3C(=O)NC3CCCC3)n2)cc(OC)c1OC
Show InChI InChI=1S/C24H28N6O4/c1-32-19-12-16(13-20(33-2)21(19)34-3)28-23-25-14-26-24(30-23)29-18-11-7-6-10-17(18)22(31)27-15-8-4-5-9-15/h6-7,10-15H,4-5,8-9H2,1-3H3,(H,27,31)(H2,25,26,28,29,30)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438059
PNG
(CHEMBL2409581)
Show SMILES CCC(CC)NC(=O)c1ccccc1Nc1ncnc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C24H30N6O4/c1-6-15(7-2)27-22(31)17-10-8-9-11-18(17)29-24-26-14-25-23(30-24)28-16-12-19(32-3)21(34-5)20(13-16)33-4/h8-15H,6-7H2,1-5H3,(H,27,31)(H2,25,26,28,29,30)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438054
PNG
(CHEMBL2409586)
Show SMILES COc1ccc(Nc2ncnc(Nc3ccccc3NS(C)(=O)=O)n2)c(OC)c1
Show InChI InChI=1S/C18H20N6O4S/c1-27-12-8-9-15(16(10-12)28-2)22-18-20-11-19-17(23-18)21-13-6-4-5-7-14(13)24-29(3,25)26/h4-11,24H,1-3H3,(H2,19,20,21,22,23)
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n/an/a 6.10E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438060
PNG
(CHEMBL2409580)
Show SMILES COc1cc(Nc2ncnc(Nc3ccccc3C(=O)NC3CC3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H24N6O4/c1-30-17-10-14(11-18(31-2)19(17)32-3)26-21-23-12-24-22(28-21)27-16-7-5-4-6-15(16)20(29)25-13-8-9-13/h4-7,10-13H,8-9H2,1-3H3,(H,25,29)(H2,23,24,26,27,28)
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n/an/a 6.10E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438038
PNG
(CHEMBL2409600)
Show SMILES COc1cc(Nc2nc(C)nc(Nc3ccccc3NS(C)(=O)=O)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H24N6O5S/c1-12-21-19(23-13-10-16(29-2)18(31-4)17(11-13)30-3)25-20(22-12)24-14-8-6-7-9-15(14)26-32(5,27)28/h6-11,26H,1-5H3,(H2,21,22,23,24,25)
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n/an/a 7.90E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438040
PNG
(CHEMBL2409598)
Show SMILES COc1cc(Nc2ncnc(Nc3cccc(NS(C)(=O)=O)c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H22N6O5S/c1-28-15-9-14(10-16(29-2)17(15)30-3)23-19-21-11-20-18(24-19)22-12-6-5-7-13(8-12)25-31(4,26)27/h5-11,25H,1-4H3,(H2,20,21,22,23,24)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438056
PNG
(CHEMBL2409584)
Show SMILES COc1cc(Nc2ncnc(Nc3ccccc3C(=O)NCCN(C)C)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H29N7O4/c1-30(2)11-10-24-21(31)16-8-6-7-9-17(16)28-23-26-14-25-22(29-23)27-15-12-18(32-3)20(34-5)19(13-15)33-4/h6-9,12-14H,10-11H2,1-5H3,(H,24,31)(H2,25,26,27,28,29)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438055
PNG
(CHEMBL2409585)
Show SMILES COC(=O)c1ccccc1Nc1ncnc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C20H21N5O5/c1-27-15-9-12(10-16(28-2)17(15)29-3)23-19-21-11-22-20(25-19)24-14-8-6-5-7-13(14)18(26)30-4/h5-11H,1-4H3,(H2,21,22,23,24,25)
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n/an/a 1.79E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438052
PNG
(CHEMBL2409588)
Show SMILES COc1ccc(Nc2ncnc(Nc3ccccc3NC(C)=O)n2)c(OC)c1
Show InChI InChI=1S/C19H20N6O3/c1-12(26)22-14-6-4-5-7-15(14)23-18-20-11-21-19(25-18)24-16-9-8-13(27-2)10-17(16)28-3/h4-11H,1-3H3,(H,22,26)(H2,20,21,23,24,25)
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n/an/a 2.11E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438057
PNG
(CHEMBL2409583)
Show SMILES COc1cc(Nc2ncnc(Nc3ccccc3C(=O)NCCO)n2)cc(OC)c1OC
Show InChI InChI=1S/C21H24N6O5/c1-30-16-10-13(11-17(31-2)18(16)32-3)25-20-23-12-24-21(27-20)26-15-7-5-4-6-14(15)19(29)22-8-9-28/h4-7,10-12,28H,8-9H2,1-3H3,(H,22,29)(H2,23,24,25,26,27)
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n/an/a 2.38E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438036
PNG
(CHEMBL2409602)
Show SMILES COC(=O)Nc1ccccc1Nc1nc(C)nc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C21H24N6O5/c1-12-22-19(24-13-10-16(29-2)18(31-4)17(11-13)30-3)27-20(23-12)25-14-8-6-7-9-15(14)26-21(28)32-5/h6-11H,1-5H3,(H,26,28)(H2,22,23,24,25,27)
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n/an/a 3.59E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438039
PNG
(CHEMBL2409599)
Show SMILES CNc1nc(Nc2cccc(NS(C)(=O)=O)c2)nc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C20H25N7O5S/c1-21-18-24-19(22-12-7-6-8-13(9-12)27-33(5,28)29)26-20(25-18)23-14-10-15(30-2)17(32-4)16(11-14)31-3/h6-11,27H,1-5H3,(H3,21,22,23,24,25,26)
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n/an/a 4.13E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438044
PNG
(CHEMBL2409594)
Show SMILES COc1cc(Nc2nc(Cl)nc(Nc3ccccc3NS(C)(=O)=O)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H21ClN6O5S/c1-29-14-9-11(10-15(30-2)16(14)31-3)21-18-23-17(20)24-19(25-18)22-12-7-5-6-8-13(12)26-32(4,27)28/h5-10,26H,1-4H3,(H2,21,22,23,24,25)
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n/an/a 4.19E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438037
PNG
(CHEMBL2409601)
Show SMILES COc1cc(Nc2nc(C)nc(Nc3ccccc3NC(C)=O)n2)cc(OC)c1OC
Show InChI InChI=1S/C21H24N6O4/c1-12-22-20(25-14-10-17(29-3)19(31-5)18(11-14)30-4)27-21(23-12)26-16-9-7-6-8-15(16)24-13(2)28/h6-11H,1-5H3,(H,24,28)(H2,22,23,25,26,27)
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n/an/a 5.08E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438035
PNG
(CHEMBL2409603)
Show SMILES COc1cc(Nc2nc(C)nc(Nc3ccccc3NC(=O)N(C)C)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H27N7O4/c1-13-23-20(25-14-11-17(31-4)19(33-6)18(12-14)32-5)28-21(24-13)26-15-9-7-8-10-16(15)27-22(30)29(2)3/h7-12H,1-6H3,(H,27,30)(H2,23,24,25,26,28)
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n/an/a 5.43E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438041
PNG
(CHEMBL2409597)
Show SMILES COc1cc(Nc2nc(Cl)nc(Nc3cccc(NS(C)(=O)=O)c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H21ClN6O5S/c1-29-14-9-13(10-15(30-2)16(14)31-3)22-19-24-17(20)23-18(25-19)21-11-6-5-7-12(8-11)26-32(4,27)28/h5-10,26H,1-4H3,(H2,21,22,23,24,25)
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n/an/a 5.78E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438042
PNG
(CHEMBL2409596)
Show SMILES CNc1nc(Nc2cc(OC)c(OC)c(OC)c2)nc(Nc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C20H25N7O5S/c1-21-18-24-19(22-12-10-15(30-2)17(32-4)16(11-12)31-3)26-20(25-18)23-13-8-6-7-9-14(13)27-33(5,28)29/h6-11,27H,1-5H3,(H3,21,22,23,24,25,26)
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n/an/a 6.59E+4n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50438034
PNG
(CHEMBL2409604)
Show SMILES COc1cc(Nc2nc(Nc3ccccc3NC(C)=O)nc(n2)C(F)(F)F)cc(OC)c1OC
Show InChI InChI=1S/C21H21F3N6O4/c1-11(31)25-13-7-5-6-8-14(13)27-20-29-18(21(22,23)24)28-19(30-20)26-12-9-15(32-2)17(34-4)16(10-12)33-3/h5-10H,1-4H3,(H,25,31)(H2,26,27,28,29,30)
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n/an/a 1.26E+5n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...

Bioorg Med Chem Lett 23: 4552-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.038
BindingDB Entry DOI: 10.7270/Q2GM88RC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%