Found 24 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442661
(CHEMBL2442021)Show SMILES CCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1C |r| Show InChI InChI=1S/C23H30N2O2/c1-3-25(20-12-8-11-19(24)15-20)23(26)21-13-6-7-14-22(21)27-16-18-10-5-4-9-17(18)2/h4-7,9-10,13-14,19-20H,3,8,11-12,15-16,24H2,1-2H3/t19-,20+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442654
(CHEMBL2442013)Show SMILES CCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C22H27ClN2O2/c1-2-25(19-7-5-6-18(24)14-19)22(26)20-8-3-4-9-21(20)27-15-16-10-12-17(23)13-11-16/h3-4,8-13,18-19H,2,5-7,14-15,24H2,1H3/t18-,19+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442659
(CHEMBL2442019)Show SMILES CCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1F |r| Show InChI InChI=1S/C22H27FN2O2/c1-2-25(18-10-7-9-17(24)14-18)22(26)19-11-4-6-13-21(19)27-15-16-8-3-5-12-20(16)23/h3-6,8,11-13,17-18H,2,7,9-10,14-15,24H2,1H3/t17-,18+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442657
(CHEMBL2442017)Show SMILES CCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1Cl |r| Show InChI InChI=1S/C22H27ClN2O2/c1-2-25(18-10-7-9-17(24)14-18)22(26)19-11-4-6-13-21(19)27-15-16-8-3-5-12-20(16)23/h3-6,8,11-13,17-18H,2,7,9-10,14-15,24H2,1H3/t17-,18+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442662
(CHEMBL2442022)Show SMILES CCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C22H28N2O2/c1-2-24(19-12-8-11-18(23)15-19)22(25)20-13-6-7-14-21(20)26-16-17-9-4-3-5-10-17/h3-7,9-10,13-14,18-19H,2,8,11-12,15-16,23H2,1H3/t18-,19+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442656
(CHEMBL2442016)Show SMILES CCN([C@H]1CCC[C@@H](N)C1)C(=O)c1ccccc1OCc1ccccc1Cl |r| Show InChI InChI=1S/C22H27ClN2O2/c1-2-25(18-10-7-9-17(24)14-18)22(26)19-11-4-6-13-21(19)27-15-16-8-3-5-12-20(16)23/h3-6,8,11-13,17-18H,2,7,9-10,14-15,24H2,1H3/t17-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442655
(CHEMBL2442015)Show SMILES CCN(C1CCCC(N)C1)C(=O)c1ccccc1OCc1cccc(Cl)c1 Show InChI InChI=1S/C22H27ClN2O2/c1-2-25(19-10-6-9-18(24)14-19)22(26)20-11-3-4-12-21(20)27-15-16-7-5-8-17(23)13-16/h3-5,7-8,11-13,18-19H,2,6,9-10,14-15,24H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442653
(CHEMBL2442014)Show SMILES CCN([C@H]1CCC[C@@H](N)C1)C(=O)c1ccccc1OCc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C22H27ClN2O2/c1-2-25(19-7-5-6-18(24)14-19)22(26)20-8-3-4-9-21(20)27-15-16-10-12-17(23)13-11-16/h3-4,8-13,18-19H,2,5-7,14-15,24H2,1H3/t18-,19+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 254 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442660
(CHEMBL2442020)Show SMILES CCN([C@H]1CCC[C@@H](N)C1)C(=O)c1ccccc1OCc1ccccc1C |r| Show InChI InChI=1S/C23H30N2O2/c1-3-25(20-12-8-11-19(24)15-20)23(26)21-13-6-7-14-22(21)27-16-18-10-5-4-9-17(18)2/h4-7,9-10,13-14,19-20H,3,8,11-12,15-16,24H2,1-2H3/t19-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 291 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442658
(CHEMBL2442018)Show SMILES CCN([C@H]1CCC[C@@H](N)C1)C(=O)c1ccccc1OCc1ccccc1F |r| Show InChI InChI=1S/C22H27FN2O2/c1-2-25(18-10-7-9-17(24)14-18)22(26)19-11-4-6-13-21(19)27-15-16-8-3-5-12-20(16)23/h3-6,8,11-13,17-18H,2,7,9-10,14-15,24H2,1H3/t17-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 435 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442651
(CHEMBL2442011)Show SMILES CCN(C1CCCC(N)C1)C(=O)c1ccccc1OCc1cccc(c1)C#N Show InChI InChI=1S/C23H27N3O2/c1-2-26(20-10-6-9-19(25)14-20)23(27)21-11-3-4-12-22(21)28-16-18-8-5-7-17(13-18)15-24/h3-5,7-8,11-13,19-20H,2,6,9-10,14,16,25H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 493 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442663
(CHEMBL2442030)Show SMILES N[C@H]1CCC[C@H](C1)N(CC1CC1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C24H30N2O2/c25-20-9-6-10-21(15-20)26(16-18-13-14-18)24(27)22-11-4-5-12-23(22)28-17-19-7-2-1-3-8-19/h1-5,7-8,11-12,18,20-21H,6,9-10,13-17,25H2/t20-,21+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 593 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442668
(CHEMBL2442037)Show SMILES CCCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C23H30N2O2/c1-2-15-25(20-12-8-11-19(24)16-20)23(26)21-13-6-7-14-22(21)27-17-18-9-4-3-5-10-18/h3-7,9-10,13-14,19-20H,2,8,11-12,15-17,24H2,1H3/t19-,20+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442670
(CHEMBL2442051)Show InChI InChI=1S/C21H22N2O2S/c22-12-13-23(15-18-9-6-14-26-18)21(24)19-10-4-5-11-20(19)25-16-17-7-2-1-3-8-17/h1-11,14H,12-13,15-16,22H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442667
(CHEMBL2442033)Show SMILES N[C@H]1CCC[C@H](C1)N(C1CCC1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C24H30N2O2/c25-19-10-6-13-21(16-19)26(20-11-7-12-20)24(27)22-14-4-5-15-23(22)28-17-18-8-2-1-3-9-18/h1-5,8-9,14-15,19-21H,6-7,10-13,16-17,25H2/t19-,21+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442664
(CHEMBL2442032)Show SMILES CCCCN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C24H32N2O2/c1-2-3-16-26(21-13-9-12-20(25)17-21)24(27)22-14-7-8-15-23(22)28-18-19-10-5-4-6-11-19/h4-8,10-11,14-15,20-21H,2-3,9,12-13,16-18,25H2,1H3/t20-,21+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442652
(CHEMBL2442012)Show InChI InChI=1S/C23H27N3O2/c1-2-26(20-11-7-10-19(25)14-20)23(27)21-12-5-6-13-22(21)28-16-18-9-4-3-8-17(18)15-24/h3-6,8-9,12-13,19-20H,2,7,10-11,14,16,25H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442666
(CHEMBL2442034)Show SMILES N[C@H]1CCC[C@H](C1)N(C1CC1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C23H28N2O2/c24-18-9-6-10-20(15-18)25(19-13-14-19)23(26)21-11-4-5-12-22(21)27-16-17-7-2-1-3-8-17/h1-5,7-8,11-12,18-20H,6,9-10,13-16,24H2/t18-,20+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442669
(CHEMBL2442036)Show SMILES CN([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C21H26N2O2/c1-23(18-11-7-10-17(22)14-18)21(24)19-12-5-6-13-20(19)25-15-16-8-3-2-4-9-16/h2-6,8-9,12-13,17-18H,7,10-11,14-15,22H2,1H3/t17-,18+/m0/s1 | PDB
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| n/a | n/a | 3.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442650
(CHEMBL2442010)Show SMILES CCN(C1CCCC(N)C1)C(=O)c1ccccc1OCc1ccc(cc1)C#N Show InChI InChI=1S/C23H27N3O2/c1-2-26(20-7-5-6-19(25)14-20)23(27)21-8-3-4-9-22(21)28-16-18-12-10-17(15-24)11-13-18/h3-4,8-13,19-20H,2,5-7,14,16,25H2,1H3 | PDB
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| n/a | n/a | 6.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442665
(CHEMBL2442031)Show SMILES CC(C)N([C@@H]1CCC[C@H](N)C1)C(=O)c1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C23H30N2O2/c1-17(2)25(20-12-8-11-19(24)15-20)23(26)21-13-6-7-14-22(21)27-16-18-9-4-3-5-10-18/h3-7,9-10,13-14,17,19-20H,8,11-12,15-16,24H2,1-2H3/t19-,20+/m0/s1 | PDB
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| n/a | n/a | 8.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50318482
((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442649
(CHEMBL2441929)Show SMILES COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r| Show InChI InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50241426
(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)Show SMILES Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O |c:10| Show InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) | PDB
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| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay |
Bioorg Med Chem Lett 23: 6118-22 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
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