null
SMILES: CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
InChI Key: InChIKey=NOOLISFMXDJSKH-KXUCPTDWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Displacement of [3H]menthol from human TRPM8 expressed in HEK293 cell membranes by scintillation counting | Nat Chem Biol 3: 174-82 (2007) Article DOI: 10.1038/nchembio862 BindingDB Entry DOI: 10.7270/Q2057G4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay | Bioorg Med Chem Lett 23: 6118-22 (2013) Article DOI: 10.1016/j.bmcl.2013.09.016 BindingDB Entry DOI: 10.7270/Q2125V4N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 2.84E+4 | n/a | n/a | n/a | n/a |
Ferrara University Curated by ChEMBL | Assay Description Activation of TRPA1 channel | J Med Chem 53: 5085-107 (2010) Article DOI: 10.1021/jm100062h BindingDB Entry DOI: 10.7270/Q2416Z02 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Mus musculus) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a |
Ferrara University Curated by ChEMBL | Assay Description Antagonist activity at mouse TRPA1 channel expressed in CHO cells assessed as blockade of agonist-induced whole cell conductance by electrophysiology | J Med Chem 53: 5085-107 (2010) Article DOI: 10.1021/jm100062h BindingDB Entry DOI: 10.7270/Q2416Z02 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank US Patent | n/a | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description In the first set of data, the potency and in vitro effects of test compounds were evaluated on cloned hTRPM8 channel (encoded by the human TRPM8 gene... | Citation and Details BindingDB Entry DOI: 10.7270/Q24B34J8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a |
University of Salerno Curated by ChEMBL | Assay Description Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla... | J Med Chem 59: 2179-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01914 BindingDB Entry DOI: 10.7270/Q2B85B1Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activation | Nat Chem Biol 3: 174-82 (2007) Article DOI: 10.1038/nchembio862 BindingDB Entry DOI: 10.7270/Q2057G4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 9.60E+4 | n/a | n/a | n/a | n/a |
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL | Assay Description Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fl... | ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a |
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL | Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ... | ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50318482 ((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Binding affinity to human TRPM8 expressed in HEK293 cell membranes | Nat Chem Biol 3: 174-82 (2007) Article DOI: 10.1038/nchembio862 BindingDB Entry DOI: 10.7270/Q2057G4K | |||||||||||
More data for this Ligand-Target Pair |