BindingDB logo
myBDB logout

PubMed code 24378711

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 1.00E+3n/an/an/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 2.00E+3n/an/an/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 4.40E+3n/an/an/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 3.80E+4n/an/an/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-reciprocal ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495691
PNG
(CHEMBL3116308)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C15H14Cl4O6P2/c16-11-3-1-9(5-13(11)18)7-15(26(20,21)22,27(23,24)25)8-10-2-4-12(17)14(19)6-10/h1-6H,7-8H2,(H2,20,21,22)(H2,23,24,25)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495691
PNG
(CHEMBL3116308)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C15H14Cl4O6P2/c16-11-3-1-9(5-13(11)18)7-15(26(20,21)22,27(23,24)25)8-10-2-4-12(17)14(19)6-10/h1-6H,7-8H2,(H2,20,21,22)(H2,23,24,25)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase E92Q mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pro...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase G140S mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase E138K mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase N155H mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495691
PNG
(CHEMBL3116308)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C15H14Cl4O6P2/c16-11-3-1-9(5-13(11)18)7-15(26(20,21)22,27(23,24)25)8-10-2-4-12(17)14(19)6-10/h1-6H,7-8H2,(H2,20,21,22)(H2,23,24,25)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495691
PNG
(CHEMBL3116308)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C15H14Cl4O6P2/c16-11-3-1-9(5-13(11)18)7-15(26(20,21)22,27(23,24)25)8-10-2-4-12(17)14(19)6-10/h1-6H,7-8H2,(H2,20,21,22)(H2,23,24,25)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase E138K mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase N155H mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase G140S mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase E92Q mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pro...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.20E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.00E+4n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495691
PNG
(CHEMBL3116308)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C15H14Cl4O6P2/c16-11-3-1-9(5-13(11)18)7-15(26(20,21)22,27(23,24)25)8-10-2-4-12(17)14(19)6-10/h1-6H,7-8H2,(H2,20,21,22)(H2,23,24,25)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.50E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.56E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495688
PNG
(CHEMBL3116307)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O6P2/c9-6-2-1-5(3-7(6)10)4-8(17(11,12)13)18(14,15)16/h1-3,8H,4H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495691
PNG
(CHEMBL3116308)
Show SMILES OP(O)(=O)C(Cc1ccc(Cl)c(Cl)c1)(Cc1ccc(Cl)c(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C15H14Cl4O6P2/c16-11-3-1-9(5-13(11)18)7-15(26(20,21)22,27(23,24)25)8-10-2-4-12(17)14(19)6-10/h1-6H,7-8H2,(H2,20,21,22)(H2,23,24,25)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50240448
PNG
(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Show SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H10Cl2O7P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3,11H,4H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495690
PNG
(CHEMBL3116305)
Show SMILES OC(Cc1ccc(Cl)cc1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11ClO7P2/c9-7-3-1-6(2-4-7)5-8(10,17(11,12)13)18(14,15)16/h1-4,10H,5H2,(H2,11,12,13)(H2,14,15,16)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50495689
PNG
(CHEMBL3116306)
Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Lomonosov Moscow State University

Curated by ChEMBL


Assay Description
Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+

Eur J Med Chem 73: 73-82 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.028
BindingDB Entry DOI: 10.7270/Q24M97H3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%