Affinity Data by PubMed id=24900231

PubMed code 24900231

Found 22 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Src kinase				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JAK2				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EGFR after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Src kinase				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of FGFR-1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of VEGFR2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LYN after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of KIT after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Aurora-A after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Akt1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TIE2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of GSK3-beta after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PDK1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PDGFR-beta after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JNK1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Flt3 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Erk2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of B-Raf after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of JAK2 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PKC-alpha after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Abl1 after 60 mins by radiometric assay				ACS Med Chem Lett 1: 454-459 (2010) Article DOI: 10.1021/ml100146z BindingDB Entry DOI: 10.7270/Q2XG9RDQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%