Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386376
(CHEMBL2046865)Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6](-c1ccccc1)-c1ccccc1)-[#6](=O)-[#6]-[#6]-c1ccc(-[#8])cc1 |r| Show InChI InChI=1S/C29H34N4O3/c30-29(31)32-20-8-7-13-25(26(35)19-16-21-14-17-24(34)18-15-21)33-28(36)27(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-6,9-12,14-15,17-18,25,27,34H,7-8,13,16,19-20H2,(H,33,36)(H4,30,31,32)/t25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386365
(CHEMBL2046867)Show SMILES CCOc1cccc(c1)[C@]1([C@H]2C[C@H](C)C[C@@H]12)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H32N2O/c1-3-28-22-11-7-8-20(18-22)25(23-16-19(2)17-24(23)25)27-14-12-26(13-15-27)21-9-5-4-6-10-21/h4-11,18-19,23-24H,3,12-17H2,1-2H3/t19-,23-,24+,25+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386375
(CHEMBL2046864)Show SMILES CCOc1cccc(c1)[C@]1(CC[C@H](C)CC1)N1CCN(CC1)c1ccccc1 |r,wU:9.17,12.13,(15.93,-8.14,;17.42,-8.55,;18.51,-7.46,;18.12,-5.97,;16.61,-5.56,;16.22,-4.06,;17.33,-2.97,;18.82,-3.39,;19.22,-4.88,;19.93,-2.3,;21.25,-1.54,;21.25,,;19.93,.78,;19.93,2.32,;18.6,,;18.6,-1.54,;21.01,-3.39,;20.6,-4.87,;21.68,-5.96,;23.16,-5.57,;23.57,-4.09,;22.49,-3,;23.92,-6.9,;23.15,-8.22,;23.91,-9.54,;25.44,-9.55,;26.21,-8.22,;25.44,-6.9,)| Show InChI InChI=1S/C25H34N2O/c1-3-28-24-11-7-8-22(20-24)25(14-12-21(2)13-15-25)27-18-16-26(17-19-27)23-9-5-4-6-10-23/h4-11,20-21H,3,12-19H2,1-2H3/t21-,25+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386372
(CHEMBL2046861)Show SMILES C[C@H]1C[C@H]2[C@@H](C1)[C@@]2(N1CCN(CC1)c1ccccc1)c1ccc(O)cc1 |r| Show InChI InChI=1S/C23H28N2O/c1-17-15-21-22(16-17)23(21,18-7-9-20(26)10-8-18)25-13-11-24(12-14-25)19-5-3-2-4-6-19/h2-10,17,21-22,26H,11-16H2,1H3/t17-,21-,22+,23+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386374
(CHEMBL2046863)Show SMILES C[C@H]1C[C@H]2[C@@H](C1)[C@@]2(N1CCN(CC1)c1ccccc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C23H27FN2/c1-17-15-21-22(16-17)23(21,18-7-9-19(24)10-8-18)26-13-11-25(12-14-26)20-5-3-2-4-6-20/h2-10,17,21-22H,11-16H2,1H3/t17-,21-,22+,23+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386369
(CHEMBL2046858)Show SMILES C[C@H]1C[C@H]2[C@@H](C1)[C@@]2(N1CCN(CC1)c1ccccc1)c1cccc(N)c1 |r| Show InChI InChI=1S/C23H29N3/c1-17-14-21-22(15-17)23(21,18-6-5-7-19(24)16-18)26-12-10-25(11-13-26)20-8-3-2-4-9-20/h2-9,16-17,21-22H,10-15,24H2,1H3/t17-,21-,22+,23+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386368
(CHEMBL2046870)Show SMILES COc1cccc(c1)[C@]1([C@H]2C[C@H](C)C[C@@H]12)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C24H30N2O/c1-18-15-22-23(16-18)24(22,19-7-6-10-21(17-19)27-2)26-13-11-25(12-14-26)20-8-4-3-5-9-20/h3-10,17-18,22-23H,11-16H2,1-2H3/t18-,22-,23+,24+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386371
(CHEMBL2046860)Show SMILES C[C@H]1C[C@H]2[C@@H](C1)[C@@]2(N1CCN(CC1)c1ccccc1)c1ccc(C)cc1 |r| Show InChI InChI=1S/C24H30N2/c1-18-8-10-20(11-9-18)24(22-16-19(2)17-23(22)24)26-14-12-25(13-15-26)21-6-4-3-5-7-21/h3-11,19,22-23H,12-17H2,1-2H3/t19-,22-,23+,24+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386373
(CHEMBL2046862)Show SMILES COc1ccc(cc1)[C@]1([C@H]2C[C@H](C)C[C@@H]12)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C24H30N2O/c1-18-16-22-23(17-18)24(22,19-8-10-21(27-2)11-9-19)26-14-12-25(13-15-26)20-6-4-3-5-7-20/h3-11,18,22-23H,12-17H2,1-2H3/t18-,22-,23+,24+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386367
(CHEMBL2046869)Show SMILES COc1ccccc1[C@]1([C@H]2C[C@H](C)C[C@@H]12)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C24H30N2O/c1-18-16-21-22(17-18)24(21,20-10-6-7-11-23(20)27-2)26-14-12-25(13-15-26)19-8-4-3-5-9-19/h3-11,18,21-22H,12-17H2,1-2H3/t18-,21-,22+,24+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386366
(CHEMBL2046868)Show SMILES C[C@H]1C[C@H]2[C@@H](C1)[C@@]2(N1CCN(CC1)c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C23H28N2/c1-18-16-21-22(17-18)23(21,19-8-4-2-5-9-19)25-14-12-24(13-15-25)20-10-6-3-7-11-20/h2-11,18,21-22H,12-17H2,1H3/t18-,21-,22+,23+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50386370
(CHEMBL2046859)Show SMILES C[C@H]1C[C@H]2[C@@H](C1)[C@@]2(N1CCN(CC1)c1ccccc1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H27ClN2/c1-17-14-21-22(15-17)23(21,18-6-5-7-19(24)16-18)26-12-10-25(11-13-26)20-8-3-2-4-9-20/h2-9,16-17,21-22H,10-15H2,1H3/t17-,21-,22+,23+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting |
ACS Med Chem Lett 3: 222-226 (2012)
Article DOI: 10.1021/ml200265m
BindingDB Entry DOI: 10.7270/Q2ZP475V |
More data for this
Ligand-Target Pair | |
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