| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 1 |
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| Ligand | BDBM50386376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_826725 (CHEMBL2051172) |
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| Ki | 15±n/a nM |
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| Citation |  Hu, S; Huang, Y; Deshpande, M; Luo, G; Bruce, MA; Chen, L; Mattson, G; Iben, LG; Zhang, J; Russell, JW; Clarke, WJ; Hogan, JB; Ortiz, A; Flint, O; Henwood, A; Gao, Q; Antal-Zimanyi, I; Poindexter, GS Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists. ACS Med Chem Lett3:222-226 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 1 |
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| Name: | Neuropeptide Y receptor type 1 |
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| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44399.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y1 NPY1R HUMAN::P25929 |
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| Residue: | 384 |
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| Sequence: | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
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| BDBM50386376 |
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| n/a |
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| Name | BDBM50386376 |
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| Synonyms: | CHEMBL2046865 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34N4O3 |
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| Mol. Mass. | 486.6053 |
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| SMILES | [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6](-c1ccccc1)-c1ccccc1)-[#6](=O)-[#6]-[#6]-c1ccc(-[#8])cc1 |r| |
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| Structure | 
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