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PubMed code 24900572

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426487
PNG
(CHEMBL2322708)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(cc1C(F)(F)F)C(N)=O |r|
Show InChI InChI=1S/C20H21F6N3O4S2/c1-11-10-28(14-4-3-12(17(27)30)9-13(14)19(21,22)23)7-8-29(11)35(32,33)16-6-5-15(34-16)18(2,31)20(24,25)26/h3-6,9,11,31H,7-8,10H2,1-2H3,(H2,27,30)/t11-,18+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426484
PNG
(CHEMBL2323017)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426488
PNG
(CHEMBL2322707)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(cc1C(F)(F)F)C(N)=O |r|
Show InChI InChI=1S/C20H21F6N3O4S2/c1-11-10-28(14-4-3-12(17(27)30)9-13(14)19(21,22)23)7-8-29(11)35(32,33)16-6-5-15(34-16)18(2,31)20(24,25)26/h3-6,9,11,31H,7-8,10H2,1-2H3,(H2,27,30)/t11-,18-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426479
PNG
(CHEMBL2323023)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)C(O)(c1nnc[nH]1)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C20H18F7N5O3S2/c1-11-9-31(14-3-2-12(21)8-13(14)19(22,23)24)6-7-32(11)37(34,35)16-5-4-15(36-16)18(33,20(25,26)27)17-28-10-29-30-17/h2-5,8,10-11,33H,6-7,9H2,1H3,(H,28,29,30)/t11-,18?/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426484
PNG
(CHEMBL2323017)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426489
PNG
(CHEMBL2322706)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426487
PNG
(CHEMBL2322708)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(cc1C(F)(F)F)C(N)=O |r|
Show InChI InChI=1S/C20H21F6N3O4S2/c1-11-10-28(14-4-3-12(17(27)30)9-13(14)19(21,22)23)7-8-29(11)35(32,33)16-6-5-15(34-16)18(2,31)20(24,25)26/h3-6,9,11,31H,7-8,10H2,1-2H3,(H2,27,30)/t11-,18+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426480
PNG
(CHEMBL2323022)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426479
PNG
(CHEMBL2323023)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)C(O)(c1nnc[nH]1)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C20H18F7N5O3S2/c1-11-9-31(14-3-2-12(21)8-13(14)19(22,23)24)6-7-32(11)37(34,35)16-5-4-15(36-16)18(33,20(25,26)27)17-28-10-29-30-17/h2-5,8,10-11,33H,6-7,9H2,1H3,(H,28,29,30)/t11-,18?/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426489
PNG
(CHEMBL2322706)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426483
PNG
(CHEMBL2323018)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426482
PNG
(CHEMBL2323019)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ncc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H17F7N4O4S2/c1-9-8-28(12-3-2-10(19)6-11(12)17(20,21)22)4-5-29(9)35(32,33)15-27-7-13(34-15)16(31,14(26)30)18(23,24)25/h2-3,6-7,9,31H,4-5,8H2,1H3,(H2,26,30)/t9-,16-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426487
PNG
(CHEMBL2322708)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(cc1C(F)(F)F)C(N)=O |r|
Show InChI InChI=1S/C20H21F6N3O4S2/c1-11-10-28(14-4-3-12(17(27)30)9-13(14)19(21,22)23)7-8-29(11)35(32,33)16-6-5-15(34-16)18(2,31)20(24,25)26/h3-6,9,11,31H,7-8,10H2,1-2H3,(H2,27,30)/t11-,18+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426488
PNG
(CHEMBL2322707)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(cc1C(F)(F)F)C(N)=O |r|
Show InChI InChI=1S/C20H21F6N3O4S2/c1-11-10-28(14-4-3-12(17(27)30)9-13(14)19(21,22)23)7-8-29(11)35(32,33)16-6-5-15(34-16)18(2,31)20(24,25)26/h3-6,9,11,31H,7-8,10H2,1-2H3,(H2,27,30)/t11-,18-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426489
PNG
(CHEMBL2322706)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426483
PNG
(CHEMBL2323018)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426488
PNG
(CHEMBL2322707)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(cc1C(F)(F)F)C(N)=O |r|
Show InChI InChI=1S/C20H21F6N3O4S2/c1-11-10-28(14-4-3-12(17(27)30)9-13(14)19(21,22)23)7-8-29(11)35(32,33)16-6-5-15(34-16)18(2,31)20(24,25)26/h3-6,9,11,31H,7-8,10H2,1-2H3,(H2,27,30)/t11-,18-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426480
PNG
(CHEMBL2323022)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426482
PNG
(CHEMBL2323019)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ncc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H17F7N4O4S2/c1-9-8-28(12-3-2-10(19)6-11(12)17(20,21)22)4-5-29(9)35(32,33)15-27-7-13(34-15)16(31,14(26)30)18(23,24)25/h2-3,6-7,9,31H,4-5,8H2,1H3,(H2,26,30)/t9-,16-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426479
PNG
(CHEMBL2323023)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)C(O)(c1nnc[nH]1)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C20H18F7N5O3S2/c1-11-9-31(14-3-2-12(21)8-13(14)19(22,23)24)6-7-32(11)37(34,35)16-5-4-15(36-16)18(33,20(25,26)27)17-28-10-29-30-17/h2-5,8,10-11,33H,6-7,9H2,1H3,(H,28,29,30)/t11-,18?/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426485
PNG
(CHEMBL2322710)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426477
PNG
(CHEMBL2322702)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cn(C)c(n1)C(C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H21F7N4O3S/c1-11-9-29(14-5-4-12(20)8-13(14)18(21,22)23)6-7-30(11)34(32,33)15-10-28(3)16(27-15)17(2,31)19(24,25)26/h4-5,8,10-11,31H,6-7,9H2,1-3H3/t11-,17?/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426485
PNG
(CHEMBL2322710)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426481
PNG
(CHEMBL2323020)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ncc(s1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H17F7N4O4S2/c1-9-8-28(12-3-2-10(19)6-11(12)17(20,21)22)4-5-29(9)35(32,33)15-27-7-13(34-15)16(31,14(26)30)18(23,24)25/h2-3,6-7,9,31H,4-5,8H2,1H3,(H2,26,30)/t9-,16+/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426482
PNG
(CHEMBL2323019)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ncc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H17F7N4O4S2/c1-9-8-28(12-3-2-10(19)6-11(12)17(20,21)22)4-5-29(9)35(32,33)15-27-7-13(34-15)16(31,14(26)30)18(23,24)25/h2-3,6-7,9,31H,4-5,8H2,1H3,(H2,26,30)/t9-,16-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426484
PNG
(CHEMBL2323017)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426486
PNG
(CHEMBL2322709)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426485
PNG
(CHEMBL2322710)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19+/m1/s1
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n/an/a 41n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426477
PNG
(CHEMBL2322702)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cn(C)c(n1)C(C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H21F7N4O3S/c1-11-9-29(14-5-4-12(20)8-13(14)18(21,22)23)6-7-30(11)34(32,33)15-10-28(3)16(27-15)17(2,31)19(24,25)26/h4-5,8,10-11,31H,6-7,9H2,1-3H3/t11-,17?/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426486
PNG
(CHEMBL2322709)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426481
PNG
(CHEMBL2323020)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ncc(s1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H17F7N4O4S2/c1-9-8-28(12-3-2-10(19)6-11(12)17(20,21)22)4-5-29(9)35(32,33)15-27-7-13(34-15)16(31,14(26)30)18(23,24)25/h2-3,6-7,9,31H,4-5,8H2,1H3,(H2,26,30)/t9-,16+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426483
PNG
(CHEMBL2323018)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19+/m1/s1
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n/an/a 51n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426486
PNG
(CHEMBL2322709)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426477
PNG
(CHEMBL2322702)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cn(C)c(n1)C(C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H21F7N4O3S/c1-11-9-29(14-5-4-12(20)8-13(14)18(21,22)23)6-7-30(11)34(32,33)15-10-28(3)16(27-15)17(2,31)19(24,25)26/h4-5,8,10-11,31H,6-7,9H2,1-3H3/t11-,17?/m1/s1
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n/an/a 77n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426476
PNG
(CHEMBL2322703)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1nc(n(C)n1)C(C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H20F7N5O3S/c1-10-9-29(13-5-4-11(19)8-12(13)17(20,21)22)6-7-30(10)34(32,33)15-26-14(28(3)27-15)16(2,31)18(23,24)25/h4-5,8,10,31H,6-7,9H2,1-3H3/t10-,16?/m1/s1
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n/an/a 104n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50426480
PNG
(CHEMBL2323022)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17+/m1/s1
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n/an/a 145n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426481
PNG
(CHEMBL2323020)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ncc(s1)[C@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H17F7N4O4S2/c1-9-8-28(12-3-2-10(19)6-11(12)17(20,21)22)4-5-29(9)35(32,33)15-27-7-13(34-15)16(31,14(26)30)18(23,24)25/h2-3,6-7,9,31H,4-5,8H2,1H3,(H2,26,30)/t9-,16+/m1/s1
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n/an/a 145n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426476
PNG
(CHEMBL2322703)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1nc(n(C)n1)C(C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H20F7N5O3S/c1-10-9-29(13-5-4-11(19)8-12(13)17(20,21)22)6-7-30(10)34(32,33)15-26-14(28(3)27-15)16(2,31)18(23,24)25/h4-5,8,10,31H,6-7,9H2,1-3H3/t10-,16?/m1/s1
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n/an/a 165n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))		BDBM50426476
PNG
(CHEMBL2322703)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1nc(n(C)n1)C(C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C18H20F7N5O3S/c1-10-9-29(13-5-4-11(19)8-12(13)17(20,21)22)6-7-30(10)34(32,33)15-26-14(28(3)27-15)16(2,31)18(23,24)25/h4-5,8,10,31H,6-7,9H2,1-3H3/t10-,16?/m1/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PPARbeta (unknown origin)

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase type 2


(Homo sapiens (Human))		BDBM50426484
PNG
(CHEMBL2323017)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]-Cortisone as substrate incubated for 30 mins prior to substrate addition measured a...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase type 2


(Homo sapiens (Human))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]-Cortisone as substrate incubated for 30 mins prior to substrate addition measured a...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem

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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PPARalpha (unknown origin)

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase type 2


(Homo sapiens (Human))		BDBM50426475
PNG
(CHEMBL2322705)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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UniChem

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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]-Cortisone as substrate incubated for 30 mins prior to substrate addition measured a...

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50426478
PNG
(CHEMBL2323021)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Show InChI InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PPARgamma (unknown origin)

ACS Med Chem Lett 4: 118-23 (2013)


Article DOI: 10.1021/ml300352x
BindingDB Entry DOI: 10.7270/Q25B03TM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%