Affinity Data by PubMed id=25180768

PubMed code 25180768

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 \| 2-[4-(3-phenylquinoxal...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin)				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 \| 2-[4-(3-phenylquinoxal...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin)				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 \| 2-[4-(3-phenylquinoxal...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of Akt1 PH domain (unknown origin)				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 \| 2-[4-(3-phenylquinoxal...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of Akt2 PH domain (unknown origin)				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 \| 2-[4-(3-phenylquinoxal...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of SGK (unknown origin)				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15148 (2,3-diphenylquinoxaline 1 \| 2-[4-(3-phenylquinoxal...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of Akt3 (unknown origin)				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50156074 (1,2-bis(3-fluorobenzylidene)hydrazine \| CHEMBL3718...) Show SMILES Fc1cccc(\C=N\N=C\c2cccc(F)c2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50024560 (CHEMBL3334989) Show SMILES COc1cccc(\C=N\N=C\c2cccc(OC)c2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50024561 (CHEMBL3334990) Show SMILES Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Silent allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50024542 (CHEMBL3334991) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50024562 (CHEMBL2431187) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Allosteric agonist activity at human muscarinic acetylcholine receptor M5				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%