Affinity Data by PubMed id=2542557

PubMed code 2542557

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thymidylate synthase (Homo sapiens (Human))	BDBM50008294 (2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of pure human thymidyllate synthase from extract of Manca human lymphoma cells				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Thymidylate synthase (Lactobacillus casei)	BDBM50008294 (2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of thymidyllate synthase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of GAR formyltransferase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Thymidylate synthase (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of pure human thymidyllate synthase from extract of Manca human lymphoma cells				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Thymidylate synthase (Lactobacillus casei)	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of thymidyllate synthase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50008294 (2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50017081 (2-{4-[(4-Oxo-2-trifluoromethyl-3,4-dihydro-quinazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of purified human thymidylate synthase from a SV40-transformed human fibroblast cell line cloned in Escherichia coli				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Thymidylate synthase (Homo sapiens (Human))	BDBM50017080 (2-{4-[(2,3-Dimethyl-4-oxo-3,4-dihydro-quinazolin-6...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of purified human thymidylate synthase from a SV40-transformed human fibroblast cell line cloned in Escherichia coli				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of thymidyllate synthase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of GAR formyltransferase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Lactobacillus casei				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of AICAR formyltransferase from extract of Manca human lymphoma cells				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM50012244 (2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of AICAR formyltransferase from extract of Manca human lymphoma cells				J Med Chem 32: 1284-9 (1989) BindingDB Entry DOI: 10.7270/Q2P55MG5
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%