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PubMed code 25437503

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034909
PNG
(CHEMBL3338127)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCN(Cc3ccccc3)C2=O)n1CC(O)=O
Show InChI InChI=1S/C30H28N2O5S/c1-21-25(18-23-12-8-9-15-27(23)38(36,37)24-13-6-3-7-14-24)29-26(32(21)20-28(33)34)16-17-31(30(29)35)19-22-10-4-2-5-11-22/h2-15H,16-20H2,1H3,(H,33,34)
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n/an/a 1.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 2.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 180 mins by radio-labelled [35S]-GTPg...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 2.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 180 mins by radio-labelled [35S]-GTPg...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034919
PNG
(CHEMBL3338136)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(ccn(C(F)F)c2=O)n1CC(O)=O
Show InChI InChI=1S/C24H20F2N2O5S/c1-15-18(22-19(28(15)14-21(29)30)11-12-27(23(22)31)24(25)26)13-16-7-5-6-10-20(16)34(32,33)17-8-3-2-4-9-17/h2-12,24H,13-14H2,1H3,(H,29,30)
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n/an/a 2.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 2.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 120 mins by radio-labelled [35S]-GTPg...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 2.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 120 mins by radio-labelled [35S]-GTPg...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 180 mins by radio-labelled [35S]-GTPg...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 120 mins by radio-labelled [35S]-GTPg...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034898
PNG
(CHEMBL3338118)
Show SMILES Cc1c(Cc2ccc(cc2)S(=O)(=O)Cc2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H24N2O5S/c1-16-20(23-21(11-12-25-24(23)29)26(16)14-22(27)28)13-17-7-9-19(10-8-17)32(30,31)15-18-5-3-2-4-6-18/h2-10H,11-15H2,1H3,(H,25,29)(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034885
PNG
(CHEMBL3338105)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21FN2O5S/c1-14-18(22-19(10-11-25-23(22)29)26(14)13-21(27)28)12-15-4-2-3-5-20(15)32(30,31)17-8-6-16(24)7-9-17/h2-9H,10-13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 3.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 3.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 60 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034880
PNG
(CHEMBL3338101)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2F)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21FN2O5S/c1-14-16(22-18(10-11-25-23(22)29)26(14)13-21(27)28)12-15-6-2-4-8-19(15)32(30,31)20-9-5-3-7-17(20)24/h2-9H,10-13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 3.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034836
PNG
(CHEMBL3338097)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H24N2O6S/c1-15-19(23-20(10-11-25-24(23)29)26(15)14-22(27)28)13-16-12-17(32-2)8-9-21(16)33(30,31)18-6-4-3-5-7-18/h3-9,12H,10-11,13-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 3.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034833
PNG
(CHEMBL3338096)
Show SMILES Cc1c(Cc2cc(F)ccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21FN2O5S/c1-14-18(22-19(9-10-25-23(22)29)26(14)13-21(27)28)12-15-11-16(24)7-8-20(15)32(30,31)17-5-3-2-4-6-17/h2-8,11H,9-10,12-13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 3.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034876
PNG
(CHEMBL3338098)
Show SMILES Cc1c(Cc2cc(Br)ccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21BrN2O5S/c1-14-18(22-19(9-10-25-23(22)29)26(14)13-21(27)28)12-15-11-16(24)7-8-20(15)32(30,31)17-5-3-2-4-6-17/h2-8,11H,9-10,12-13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 3.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034887
PNG
(CHEMBL3338107)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12
Show InChI InChI=1S/C24H24N2O6S/c1-15-19(23-20(11-12-25-24(23)29)26(15)14-22(27)28)13-16-5-3-4-6-21(16)33(30,31)18-9-7-17(32-2)8-10-18/h3-10H,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 3.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 60 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034882
PNG
(CHEMBL3338103)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2cccc(Cl)c2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21ClN2O5S/c1-14-18(22-19(9-10-25-23(22)29)26(14)13-21(27)28)11-15-5-2-3-8-20(15)32(30,31)17-7-4-6-16(24)12-17/h2-8,12H,9-11,13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 4.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 30 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 4.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 60 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 4.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 30 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 4.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 15 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034918
PNG
(CHEMBL3338135)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(ccn(C)c2=O)n1CC(O)=O
Show InChI InChI=1S/C24H22N2O5S/c1-16-19(23-20(26(16)15-22(27)28)12-13-25(2)24(23)29)14-17-8-6-7-11-21(17)32(30,31)18-9-4-3-5-10-18/h3-13H,14-15H2,1-2H3,(H,27,28)
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n/an/a 4.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034915
PNG
(CHEMBL3338132)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CC(C)(C)NC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H27FN2O6S/c1-15-20(24-21(29(15)14-23(30)31)13-26(2,3)28-25(24)32)12-16-11-18(35-4)7-10-22(16)36(33,34)19-8-5-17(27)6-9-19/h5-11H,12-14H2,1-4H3,(H,28,32)(H,30,31)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034914
PNG
(CHEMBL3338131)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H25FN2O5S/c1-15-19(23-20(28(15)14-22(29)30)13-25(2,3)27-24(23)31)12-16-6-4-5-7-21(16)34(32,33)18-10-8-17(26)9-11-18/h4-11H,12-14H2,1-3H3,(H,27,31)(H,29,30)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 5.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 30 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034913
PNG
(CHEMBL3338129)
Show SMILES CC(N1CCc2c(c(Cc3ccccc3S(=O)(=O)c3ccccc3)c(C)n2CC(O)=O)C1=O)C(F)(F)F
Show InChI InChI=1S/C26H25F3N2O5S/c1-16-20(14-18-8-6-7-11-22(18)37(35,36)19-9-4-3-5-10-19)24-21(31(16)15-23(32)33)12-13-30(25(24)34)17(2)26(27,28)29/h3-11,17H,12-15H2,1-2H3,(H,32,33)
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n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034881
PNG
(CHEMBL3338102)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2cccc(F)c2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21FN2O5S/c1-14-18(22-19(9-10-25-23(22)29)26(14)13-21(27)28)11-15-5-2-3-8-20(15)32(30,31)17-7-4-6-16(24)12-17/h2-8,12H,9-11,13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 6.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 6.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 15 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 6.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in CHO.K1 cells co-mixing the compound and PGD2 by radio-labelled [35S]-GTPgammaS bind...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034888
PNG
(CHEMBL3338108)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H21F3N2O6S/c1-14-18(22-19(10-11-28-23(22)32)29(14)13-21(30)31)12-15-4-2-3-5-20(15)36(33,34)17-8-6-16(7-9-17)35-24(25,26)27/h2-9H,10-13H2,1H3,(H,28,32)(H,30,31)
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n/an/a 6.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 6.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 15 mins by radio-labelled [35S]-GTPga...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034907
PNG
(CHEMBL3338126)
Show SMILES CN1CCc2c(c(Cc3ccccc3S(=O)(=O)c3ccccc3)c(C)n2CC(O)=O)C1=O
Show InChI InChI=1S/C24H24N2O5S/c1-16-19(23-20(26(16)15-22(27)28)12-13-25(2)24(23)29)14-17-8-6-7-11-21(17)32(30,31)18-9-4-3-5-10-18/h3-11H,12-15H2,1-2H3,(H,27,28)
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n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 7.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034812
PNG
(CHEMBL3338130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CC(C)(C)NC2=O)n1CC(O)=O
Show InChI InChI=1S/C25H26N2O5S/c1-16-19(23-20(27(16)15-22(28)29)14-25(2,3)26-24(23)30)13-17-9-7-8-12-21(17)33(31,32)18-10-5-4-6-11-18/h4-12H,13-15H2,1-3H3,(H,26,30)(H,28,29)
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n/an/a 7.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in CHO.K1 cells co-mixing the compound and PGD2 by radio-labelled [35S]-GTPgammaS bind...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034886
PNG
(CHEMBL3338106)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(Cl)cc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H21ClN2O5S/c1-14-18(22-19(10-11-25-23(22)29)26(14)13-21(27)28)12-15-4-2-3-5-20(15)32(30,31)17-8-6-16(24)7-9-17/h2-9H,10-13H2,1H3,(H,25,29)(H,27,28)
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n/an/a 8.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034917
PNG
(CHEMBL3338134)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(cc[nH]c2=O)n1CC(O)=O
Show InChI InChI=1S/C23H20N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-12H,13-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 8.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034911
PNG
(CHEMBL3338128)
Show SMILES CC(C)N1CCc2c(c(Cc3ccccc3S(=O)(=O)c3ccccc3)c(C)n2CC(O)=O)C1=O
Show InChI InChI=1S/C26H28N2O5S/c1-17(2)27-14-13-22-25(26(27)31)21(18(3)28(22)16-24(29)30)15-19-9-7-8-12-23(19)34(32,33)20-10-5-4-6-11-20/h4-12,17H,13-16H2,1-3H3,(H,29,30)
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n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034810
PNG
(CHEMBL3338109)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN2O6S/c1-14-19(23-20(9-10-26-24(23)30)27(14)13-22(28)29)12-15-11-17(33-2)5-8-21(15)34(31,32)18-6-3-16(25)4-7-18/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in CHO.K1 cells co-mixing the compound and PGD2 by radio-labelled [35S]-GTPgammaS bind...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034809
PNG
(CHEMBL3338090)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgammaS binding assay ...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034825
PNG
(CHEMBL3338095)
Show SMILES CNC(=O)c1ccc(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c(c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H25N3O6S/c1-15-19(23-20(10-11-27-25(23)32)28(15)14-22(29)30)12-16-8-9-17(24(31)26-2)13-21(16)35(33,34)18-6-4-3-5-7-18/h3-9,13H,10-12,14H2,1-2H3,(H,26,31)(H,27,32)(H,29,30)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034821
PNG
(CHEMBL3338094)
Show SMILES COC(=O)c1ccc(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c(c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H24N2O7S/c1-15-19(23-20(10-11-26-24(23)30)27(15)14-22(28)29)12-16-8-9-17(25(31)34-2)13-21(16)35(32,33)18-6-4-3-5-7-18/h3-9,13H,10-12,14H2,1-2H3,(H,26,30)(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034883
PNG
(CHEMBL3337462)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12
Show InChI InChI=1S/C24H24N2O6S/c1-15-19(23-20(10-11-25-24(23)29)26(15)14-22(27)28)12-16-6-3-4-9-21(16)33(30,31)18-8-5-7-17(13-18)32-2/h3-9,13H,10-12,14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 12n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034814
PNG
(CHEMBL3338092)
Show SMILES Cc1c(Cc2ccc(cc2S(=O)(=O)c2ccccc2)C(F)(F)F)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H21F3N2O5S/c1-14-18(22-19(9-10-28-23(22)32)29(14)13-21(30)31)11-15-7-8-16(24(25,26)27)12-20(15)35(33,34)17-5-3-2-4-6-17/h2-8,12H,9-11,13H2,1H3,(H,28,32)(H,30,31)
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n/an/a 13n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034916
PNG
(CHEMBL3338133)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c(Cl)nccc2n1CC(O)=O
Show InChI InChI=1S/C23H19ClN2O4S/c1-15-18(22-19(11-12-25-23(22)24)26(15)14-21(27)28)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h2-12H,13-14H2,1H3,(H,27,28)
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n/an/a 16n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034819
PNG
(CHEMBL3338093)
Show SMILES Cc1c(Cc2ccc(cc2S(=O)(=O)c2ccccc2)C(O)=O)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H22N2O7S/c1-14-18(22-19(9-10-25-23(22)29)26(14)13-21(27)28)11-15-7-8-16(24(30)31)12-20(15)34(32,33)17-5-3-2-4-6-17/h2-8,12H,9-11,13H2,1H3,(H,25,29)(H,27,28)(H,30,31)
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n/an/a 19n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034813
PNG
(CHEMBL3338091)
Show SMILES COc1cccc(Cc2c(C)n(CC(O)=O)c3CCNC(=O)c23)c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H24N2O6S/c1-15-18(22-19(11-12-25-24(22)29)26(15)14-21(27)28)13-16-7-6-10-20(32-2)23(16)33(30,31)17-8-4-3-5-9-17/h3-10H,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034893
PNG
(CHEMBL3338114)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)N2CCOCC2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C21H25N3O6S/c1-14-16(20-17(6-7-22-21(20)27)24(14)13-19(25)26)12-15-4-2-3-5-18(15)31(28,29)23-8-10-30-11-9-23/h2-5H,6-13H2,1H3,(H,22,27)(H,25,26)
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n/an/a 22n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034894
PNG
(CHEMBL3338115)
Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12
Show InChI InChI=1S/C25H27N3O5S/c1-17-20(24-21(12-13-26-25(24)31)28(17)16-23(29)30)14-19-10-6-7-11-22(19)34(32,33)27(2)15-18-8-4-3-5-9-18/h3-11H,12-16H2,1-2H3,(H,26,31)(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034877
PNG
(CHEMBL3338099)
Show SMILES Cc1c(Cc2cc(ccc2S(=O)(=O)c2ccccc2)C#N)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H21N3O5S/c1-15-19(23-20(9-10-26-24(23)30)27(15)14-22(28)29)12-17-11-16(13-25)7-8-21(17)33(31,32)18-5-3-2-4-6-18/h2-8,11H,9-10,12,14H2,1H3,(H,26,30)(H,28,29)
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n/an/a 28n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034892
PNG
(CHEMBL3338113)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)C2CCCCC2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H28N2O5S/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)31(29,30)17-8-3-2-4-9-17/h5-7,10,17H,2-4,8-9,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 28n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034902
PNG
(CHEMBL3338122)
Show SMILES Cc1c(Cc2ccccc2C(O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H24N2O4/c1-15-19(22-20(11-12-25-24(22)30)26(15)14-21(27)28)13-17-9-5-6-10-18(17)23(29)16-7-3-2-4-8-16/h2-10,23,29H,11-14H2,1H3,(H,25,30)(H,27,28)
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n/an/a 32n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034889
PNG
(CHEMBL3338110)
Show SMILES C[C@@H](C(O)=O)n1c(C)c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c1CCNC2=O |r|
Show InChI InChI=1S/C24H24N2O5S/c1-15-19(22-20(12-13-25-23(22)27)26(15)16(2)24(28)29)14-17-8-6-7-11-21(17)32(30,31)18-9-4-3-5-10-18/h3-11,16H,12-14H2,1-2H3,(H,25,27)(H,28,29)/t16-/m0/s1
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n/an/a 91n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034903
PNG
(CHEMBL3338123)
Show SMILES Cc1c(Cc2ccccc2Cc2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H24N2O3/c1-16-20(23-21(11-12-25-24(23)29)26(16)15-22(27)28)14-19-10-6-5-9-18(19)13-17-7-3-2-4-8-17/h2-10H,11-15H2,1H3,(H,25,29)(H,27,28)
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n/an/a 120n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034897
PNG
(CHEMBL3338117)
Show SMILES Cc1c(Cc2ccc(cc2)S(=O)(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O5S/c1-15-19(22-20(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-9-18(10-8-16)31(29,30)17-5-3-2-4-6-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 170n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034884
PNG
(CHEMBL3338104)
Show SMILES CNC(=O)c1cccc(c1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12
Show InChI InChI=1S/C25H25N3O6S/c1-15-19(23-20(10-11-27-25(23)32)28(15)14-22(29)30)13-16-6-3-4-9-21(16)35(33,34)18-8-5-7-17(12-18)24(31)26-2/h3-9,12H,10-11,13-14H2,1-2H3,(H,26,31)(H,27,32)(H,29,30)
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n/an/a 240n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034900
PNG
(CHEMBL3338120)
Show SMILES CCN(Cc1ccccc1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12)C(=O)C1CC1
Show InChI InChI=1S/C24H29N3O4/c1-3-26(24(31)16-8-9-16)13-18-7-5-4-6-17(18)12-19-15(2)27(14-21(28)29)20-10-11-25-23(30)22(19)20/h4-7,16H,3,8-14H2,1-2H3,(H,25,30)(H,28,29)
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n/an/a 240n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034890
PNG
(CHEMBL3338111)
Show SMILES C[C@H](C(O)=O)n1c(C)c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2c1CCNC2=O |r|
Show InChI InChI=1S/C24H24N2O5S/c1-15-19(22-20(12-13-25-23(22)27)26(15)16(2)24(28)29)14-17-8-6-7-11-21(17)32(30,31)18-9-4-3-5-10-18/h3-11,16H,12-14H2,1-2H3,(H,25,27)(H,28,29)/t16-/m1/s1
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n/an/a 430n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034905
PNG
(CHEMBL3338124)
Show SMILES Cc1c(Cc2ccccc2-c2cccc3ccccc23)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C27H24N2O3/c1-17-23(26-24(13-14-28-27(26)32)29(17)16-25(30)31)15-19-8-3-5-11-21(19)22-12-6-9-18-7-2-4-10-20(18)22/h2-12H,13-16H2,1H3,(H,28,32)(H,30,31)
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n/an/a 480n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034906
PNG
(CHEMBL3338125)
Show SMILES Cc1c(Cc2ccccc2Oc2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C23H22N2O4/c1-15-18(22-19(11-12-24-23(22)28)25(15)14-21(26)27)13-16-7-5-6-10-20(16)29-17-8-3-2-4-9-17/h2-10H,11-14H2,1H3,(H,24,28)(H,26,27)
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n/an/a 530n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034891
PNG
(CHEMBL3338112)
Show SMILES CCS(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12
Show InChI InChI=1S/C19H22N2O5S/c1-3-27(25,26)16-7-5-4-6-13(16)10-14-12(2)21(11-17(22)23)15-8-9-20-19(24)18(14)15/h4-7H,3,8-11H2,1-2H3,(H,20,24)(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034899
PNG
(CHEMBL3338119)
Show SMILES Cc1c(Cc2ccccc2Cn2ccnn2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C20H21N5O3/c1-13-16(19-17(6-7-21-20(19)28)25(13)12-18(26)27)10-14-4-2-3-5-15(14)11-24-9-8-22-23-24/h2-5,8-9H,6-7,10-12H2,1H3,(H,21,28)(H,26,27)
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n/an/a 800n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034901
PNG
(CHEMBL3338121)
Show SMILES Cc1c(Cc2ccccc2C(=O)c2ccccc2)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H22N2O4/c1-15-19(22-20(11-12-25-24(22)30)26(15)14-21(27)28)13-17-9-5-6-10-18(17)23(29)16-7-3-2-4-8-16/h2-10H,11-14H2,1H3,(H,25,30)(H,27,28)
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n/an/a 810n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034895
PNG
(CHEMBL3338116)
Show SMILES Cc1c(Cc2ccc(cc2)S(C)(=O)=O)c2c(CCNC2=O)n1CC(O)=O
Show InChI InChI=1S/C18H20N2O5S/c1-11-14(9-12-3-5-13(6-4-12)26(2,24)25)17-15(7-8-19-18(17)23)20(11)10-16(21)22/h3-6H,7-10H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 900n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034879
PNG
(CHEMBL3338100)
Show SMILES COc1cccc(c1Cc1c(C)n(CC(O)=O)c2CCNC(=O)c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H24N2O6S/c1-15-17(23-19(11-12-25-24(23)29)26(15)14-22(27)28)13-18-20(32-2)9-6-10-21(18)33(30,31)16-7-4-3-5-8-16/h3-10H,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5111-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.026
BindingDB Entry DOI: 10.7270/Q2N01840
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%