Found 29 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034956
(CHEMBL3338150)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)n2cccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-4-5-14)13-15-10-16(23(24,25)26)6-7-18(15)19-11-17(12-20(30)31)29-9-3-8-27-21(19)29/h3,6-11,14H,2,4-5,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034951
(CHEMBL3338147)Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccncc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-3-4-14)11-15-9-16(23(24,25)26)5-6-17(15)19-12-29(13-21(30)31)20-7-8-27-10-18(19)20/h5-10,12,14H,2-4,11,13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034954
(CHEMBL3338149)Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)12-16-10-17(23(24,25)26)7-8-19(16)29-13-15(11-20(30)31)18-4-3-9-27-21(18)29/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034956
(CHEMBL3338150)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)n2cccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-4-5-14)13-15-10-16(23(24,25)26)6-7-18(15)19-11-17(12-20(30)31)29-9-3-8-27-21(19)29/h3,6-11,14H,2,4-5,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50397641
(CHEMBL2181754)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)ccc1OC)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H24F3NO4/c1-3-27(22(30)15-5-6-15)13-16-12-17(23(24,25)26)7-8-18(16)19-10-14(11-21(28)29)4-9-20(19)31-2/h4,7-10,12,15H,3,5-6,11,13H2,1-2H3,(H,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034948
(CHEMBL3338146)Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)11-15-10-16(23(24,25)26)7-8-17(15)18-12-29(13-20(30)31)19-4-3-9-27-21(18)19/h3-4,7-10,12,14H,2,5-6,11,13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034948
(CHEMBL3338146)Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)11-15-10-16(23(24,25)26)7-8-17(15)18-12-29(13-20(30)31)19-4-3-9-27-21(18)19/h3-4,7-10,12,14H,2,5-6,11,13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50397641
(CHEMBL2181754)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)ccc1OC)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H24F3NO4/c1-3-27(22(30)15-5-6-15)13-16-12-17(23(24,25)26)7-8-18(16)19-10-14(11-21(28)29)4-9-20(19)31-2/h4,7-10,12,15H,3,5-6,11,13H2,1-2H3,(H,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034957
(CHEMBL3338151)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)c2ccncn12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-3-4-14)12-16-9-17(23(24,25)26)5-6-18(16)20-10-15(11-21(30)31)19-7-8-27-13-29(19)20/h5-10,13-14H,2-4,11-12H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034946
(CHEMBL3338145)Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)12-16-11-17(24(25,26)27)9-10-18(16)20-13-29(14-22(30)31)21-6-4-3-5-19(20)21/h3-6,9-11,13,15H,2,7-8,12,14H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034945
(CHEMBL3338144)Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-7-8-14)12-15-11-16(23(24,25)26)9-10-17(15)21-18-5-3-4-6-19(18)29(27-21)13-20(30)31/h3-6,9-11,14H,2,7-8,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034954
(CHEMBL3338149)Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)12-16-10-17(23(24,25)26)7-8-19(16)29-13-15(11-20(30)31)18-4-3-9-27-21(18)29/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034957
(CHEMBL3338151)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)c2ccncn12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-3-4-14)12-16-9-17(23(24,25)26)5-6-18(16)20-10-15(11-21(30)31)19-7-8-27-13-29(19)20/h5-10,13-14H,2-4,11-12H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034953
(CHEMBL3338148)Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)13-17-11-18(24(25,26)27)9-10-20(17)29-14-16(12-22(30)31)19-5-3-4-6-21(19)29/h3-6,9-11,14-15H,2,7-8,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034921
(CHEMBL3338138)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cc2cn(C)nc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H24F3N3O3/c1-3-30(23(33)15-4-5-15)13-16-11-18(24(25,26)27)6-7-19(16)20-9-14(10-21(31)32)8-17-12-29(2)28-22(17)20/h6-9,11-12,15H,3-5,10,13H2,1-2H3,(H,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034951
(CHEMBL3338147)Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccncc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-3-4-14)11-15-9-16(23(24,25)26)5-6-17(15)19-12-29(13-21(30)31)20-7-8-27-10-18(19)20/h5-10,12,14H,2-4,11,13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034945
(CHEMBL3338144)Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-7-8-14)12-15-11-16(23(24,25)26)9-10-17(15)21-18-5-3-4-6-19(18)29(27-21)13-20(30)31/h3-6,9-11,14H,2,7-8,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034920
(CHEMBL3338137)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cc2cnn(C)c12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H24F3N3O3/c1-3-30(23(33)15-4-5-15)13-17-11-18(24(25,26)27)6-7-19(17)20-9-14(10-21(31)32)8-16-12-28-29(2)22(16)20/h6-9,11-12,15H,3-5,10,13H2,1-2H3,(H,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034921
(CHEMBL3338138)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cc2cn(C)nc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H24F3N3O3/c1-3-30(23(33)15-4-5-15)13-16-11-18(24(25,26)27)6-7-19(16)20-9-14(10-21(31)32)8-17-12-29(2)28-22(17)20/h6-9,11-12,15H,3-5,10,13H2,1-2H3,(H,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034920
(CHEMBL3338137)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cc2cnn(C)c12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H24F3N3O3/c1-3-30(23(33)15-4-5-15)13-17-11-18(24(25,26)27)6-7-19(17)20-9-14(10-21(31)32)8-16-12-28-29(2)22(16)20/h6-9,11-12,15H,3-5,10,13H2,1-2H3,(H,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034946
(CHEMBL3338145)Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)12-16-11-17(24(25,26)27)9-10-18(16)20-13-29(14-22(30)31)21-6-4-3-5-19(20)21/h3-6,9-11,13,15H,2,7-8,12,14H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034958
(CHEMBL3338152)Show SMILES CCN(Cc1cc(ccc1-c1nc(CC(O)=O)c2ccccn12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-6-7-14)13-15-11-16(23(24,25)26)8-9-17(15)21-27-18(12-20(30)31)19-5-3-4-10-29(19)21/h3-5,8-11,14H,2,6-7,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034953
(CHEMBL3338148)Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)13-17-11-18(24(25,26)27)9-10-20(17)29-14-16(12-22(30)31)19-5-3-4-6-21(19)29/h3-6,9-11,14-15H,2,7-8,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034958
(CHEMBL3338152)Show SMILES CCN(Cc1cc(ccc1-c1nc(CC(O)=O)c2ccccn12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-6-7-14)13-15-11-16(23(24,25)26)8-9-17(15)21-27-18(12-20(30)31)19-5-3-4-10-29(19)21/h3-5,8-11,14H,2,6-7,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor in human eosinophil assessed as inhibition of PGD2-induced cell shape change |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034943
(CHEMBL3338142)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)c2ccnn2c1)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-3-4-14)12-17-10-18(23(24,25)26)5-6-19(17)16-9-15(11-21(30)31)20-7-8-27-29(20)13-16/h5-10,13-14H,2-4,11-12H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034924
(CHEMBL3338140)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cn2ccnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)15-3-4-15)13-16-11-17(23(24,25)26)5-6-18(16)19-9-14(10-20(30)31)12-29-8-7-27-21(19)29/h5-9,11-12,15H,2-4,10,13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 159 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034926
(CHEMBL3338141)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cn2nccc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)15-3-4-15)13-16-11-17(23(24,25)26)5-6-18(16)19-9-14(10-21(30)31)12-29-20(19)7-8-27-29/h5-9,11-12,15H,2-4,10,13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 247 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034944
(CHEMBL3338143)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)c2cccn2c1)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-5-6-15)13-18-11-19(24(25,26)27)7-8-20(18)17-10-16(12-22(30)31)21-4-3-9-29(21)14-17/h3-4,7-11,14-15H,2,5-6,12-13H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50034923
(CHEMBL3338139)Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)cn2cnnc12)C(F)(F)F)C(=O)C1CC1 Show InChI InChI=1S/C22H21F3N4O3/c1-2-28(21(32)14-3-4-14)11-15-9-16(22(23,24)25)5-6-17(15)18-7-13(8-19(30)31)10-29-12-26-27-20(18)29/h5-7,9-10,12,14H,2-4,8,11H2,1H3,(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding at 1 t... |
Bioorg Med Chem Lett 24: 5118-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.005 BindingDB Entry DOI: 10.7270/Q2H70HFQ |
More data for this Ligand-Target Pair | |