BindingDB logo
myBDB logout

PubMed code 25437506

Compile data set for download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035039
PNG
(CHEMBL3338270)
Show SMILES Cc1nnc(C)n1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C22H23N5O2/c1-13-5-8-20(18(9-13)12-26-15(3)24-25-16(26)4)27-11-17(10-21(28)29)19-7-6-14(2)23-22(19)27/h5-9,11H,10,12H2,1-4H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035089
PNG
(CHEMBL3338297)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-13-3-7-19-17(11-22(32)33)12-31(24(19)29-13)21-8-6-18(25(26,27)28)9-16(21)10-20-14(2)30-34-23(20)15-4-5-15/h3,6-9,12,15H,4-5,10-11H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035088
PNG
(CHEMBL3338296)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C24H22FN3O3/c1-13-3-7-19-17(11-22(29)30)12-28(24(19)26-13)21-8-6-18(25)9-16(21)10-20-14(2)27-31-23(20)15-4-5-15/h3,6-9,12,15H,4-5,10-11H2,1-2H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035079
PNG
(CHEMBL3338287)
Show SMILES Cc1nnc(Cc2ccccc2)n1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C27H24ClN5O2/c1-17-8-10-23-20(14-26(34)35)15-33(27(23)29-17)24-11-9-22(28)13-21(24)16-32-18(2)30-31-25(32)12-19-6-4-3-5-7-19/h3-11,13,15H,12,14,16H2,1-2H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035088
PNG
(CHEMBL3338296)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C24H22FN3O3/c1-13-3-7-19-17(11-22(29)30)12-28(24(19)26-13)21-8-6-18(25)9-16(21)10-20-14(2)27-31-23(20)15-4-5-15/h3,6-9,12,15H,4-5,10-11H2,1-2H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035038
PNG
(CHEMBL3338269)
Show SMILES Cc1noc(C)c1Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C22H20FN3O3/c1-12-4-6-18-16(10-21(27)28)11-26(22(18)24-12)20-7-5-17(23)8-15(20)9-19-13(2)25-29-14(19)3/h4-8,11H,9-10H2,1-3H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035077
PNG
(CHEMBL3338285)
Show SMILES Cc1nnc(C2CC2)n1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C24H20F4N4O2/c1-13-29-30-23(14-2-3-14)32(13)10-15-8-16(24(26,27)28)4-6-18(15)20-11-31(12-22(33)34)21-7-5-17(25)9-19(20)21/h4-9,11,14H,2-3,10,12H2,1H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035091
PNG
(CHEMBL3338299)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3Cc3c(noc3C3CC3)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C27H24F3N3O3/c1-14-2-8-20-18(12-23(34)35)13-33(26(20)31-14)22-9-7-19(27(28,29)30)10-17(22)11-21-24(15-3-4-15)32-36-25(21)16-5-6-16/h2,7-10,13,15-16H,3-6,11-12H2,1H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035093
PNG
(CHEMBL3338301)
Show SMILES Cc1noc(Cc2ccccc2)c1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C28H24ClN3O3/c1-17-8-10-23-21(15-27(33)34)16-32(28(23)30-17)25-11-9-22(29)13-20(25)14-24-18(2)31-35-26(24)12-19-6-4-3-5-7-19/h3-11,13,16H,12,14-15H2,1-2H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035086
PNG
(CHEMBL3338294)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-c1cc(CC(O)=O)c2ccc(C)nn12)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-13-3-8-21-17(12-23(32)33)11-22(31(21)29-13)19-7-6-18(25(26,27)28)9-16(19)10-20-14(2)30-34-24(20)15-4-5-15/h3,6-9,11,15H,4-5,10,12H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035034
PNG
(CHEMBL3338261)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3CSC(C)(C)C)C(=O)NCCc3ccccc3)c2n1
Show InChI InChI=1S/C30H33N3O3S/c1-20-10-12-25-23(17-27(34)35)18-33(28(25)32-20)26-13-11-22(16-24(26)19-37-30(2,3)4)29(36)31-15-14-21-8-6-5-7-9-21/h5-13,16,18H,14-15,17,19H2,1-4H3,(H,31,36)(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035074
PNG
(CHEMBL3338282)
Show SMILES Cc1cnn(CC2CC2)c1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C26H28N4O2/c1-16-4-9-23(20(10-16)11-24-17(2)13-27-30(24)14-19-6-7-19)29-15-21(12-25(31)32)22-8-5-18(3)28-26(22)29/h4-5,8-10,13,15,19H,6-7,11-12,14H2,1-3H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035076
PNG
(CHEMBL3338284)
Show SMILES Cc1nnc(C2CC2)n1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C23H22ClN5O2/c1-13-3-7-19-16(10-21(30)31)11-29(23(19)25-13)20-8-6-18(24)9-17(20)12-28-14(2)26-27-22(28)15-4-5-15/h3,6-9,11,15H,4-5,10,12H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035074
PNG
(CHEMBL3338282)
Show SMILES Cc1cnn(CC2CC2)c1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C26H28N4O2/c1-16-4-9-23(20(10-16)11-24-17(2)13-27-30(24)14-19-6-7-19)29-15-21(12-25(31)32)22-8-5-18(3)28-26(22)29/h4-5,8-10,13,15,19H,6-7,11-12,14H2,1-3H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035103
PNG
(CHEMBL3337464)
Show SMILES Cc1c(-c2cccc3CN(CCc23)S(C)(=O)=O)c2cc(F)ccc2n1CC(O)=O |(5.67,-9.17,;5.99,-10.68,;7.4,-11.31,;8.74,-10.54,;10.07,-11.31,;11.42,-10.54,;11.41,-8.98,;10.07,-8.23,;10.07,-6.7,;8.74,-5.93,;7.42,-6.7,;7.41,-8.23,;8.74,-8.99,;8.74,-4.38,;10.09,-3.62,;7.2,-4.37,;7.98,-3.04,;7.24,-12.84,;8.26,-13.97,;7.79,-15.43,;8.83,-16.57,;6.29,-15.75,;5.26,-14.61,;5.74,-13.15,;4.96,-11.82,;3.42,-11.67,;2.52,-12.92,;.98,-12.77,;3.15,-14.33,)|
Show InChI InChI=1S/C21H21FN2O4S/c1-13-21(18-10-15(22)6-7-19(18)24(13)12-20(25)26)17-5-3-4-14-11-23(29(2,27)28)9-8-16(14)17/h3-7,10H,8-9,11-12H2,1-2H3,(H,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035081
PNG
(CHEMBL3338289)
Show SMILES Cc1noc(C)c1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C23H20F3N3O3/c1-12-4-7-20-22(27-12)19(10-29(20)11-21(30)31)17-6-5-16(23(24,25)26)8-15(17)9-18-13(2)28-32-14(18)3/h4-8,10H,9,11H2,1-3H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035085
PNG
(CHEMBL3338293)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-c1cc(CC(O)=O)n2ccc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-13-7-8-31-18(12-22(32)33)11-21(24(31)29-13)19-6-5-17(25(26,27)28)9-16(19)10-20-14(2)30-34-23(20)15-3-4-15/h5-9,11,15H,3-4,10,12H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035080
PNG
(CHEMBL3338288)
Show SMILES Cc1nnc(CCc2ccccc2)n1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C28H26ClN5O2/c1-18-8-11-24-21(15-27(35)36)16-34(28(24)30-18)25-12-10-23(29)14-22(25)17-33-19(2)31-32-26(33)13-9-20-6-4-3-5-7-20/h3-8,10-12,14,16H,9,13,15,17H2,1-2H3,(H,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035089
PNG
(CHEMBL3338297)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-13-3-7-19-17(11-22(32)33)12-31(24(19)29-13)21-8-6-18(25(26,27)28)9-16(21)10-20-14(2)30-34-23(20)15-4-5-15/h3,6-9,12,15H,4-5,10-11H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034980
PNG
(CHEMBL3338153)
Show SMILES CCN(Cc1ccccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H25N3O3/c1-3-25(23(29)16-9-10-16)13-17-6-4-5-7-20(17)26-14-18(12-21(27)28)19-11-8-15(2)24-22(19)26/h4-8,11,14,16H,3,9-10,12-13H2,1-2H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035077
PNG
(CHEMBL3338285)
Show SMILES Cc1nnc(C2CC2)n1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C24H20F4N4O2/c1-13-29-30-23(14-2-3-14)32(13)10-15-8-16(24(26,27)28)4-6-18(15)20-11-31(12-22(33)34)21-7-5-17(25)9-19(20)21/h4-9,11,14H,2-3,10,12H2,1H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035092
PNG
(CHEMBL3338300)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(Cl)cc3Cc3c(noc3C3CC3)C3CC3)c2n1
Show InChI InChI=1S/C26H24ClN3O3/c1-14-2-8-20-18(12-23(31)32)13-30(26(20)28-14)22-9-7-19(27)10-17(22)11-21-24(15-3-4-15)29-33-25(21)16-5-6-16/h2,7-10,13,15-16H,3-6,11-12H2,1H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035037
PNG
(CHEMBL3338268)
Show SMILES Cc1cnn(C)c1Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C22H21FN4O2/c1-13-11-24-26(3)20(13)9-15-8-17(23)5-7-19(15)27-12-16(10-21(28)29)18-6-4-14(2)25-22(18)27/h4-8,11-12H,9-10H2,1-3H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035153
PNG
(CHEMBL3338302)
Show SMILES Cc1noc(C)c1-c1cccc(c1)-c1c(C)n(CC(O)=O)c2ccc(F)cc12
Show InChI InChI=1S/C22H19FN2O3/c1-12-21(14(3)28-24-12)15-5-4-6-16(9-15)22-13(2)25(11-20(26)27)19-8-7-17(23)10-18(19)22/h4-10H,11H2,1-3H3,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035078
PNG
(CHEMBL3338286)
Show SMILES Cc1nnc(C2CC2)n1Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C24H20F4N4O2/c1-13-29-30-23(14-2-3-14)31(13)12-16-8-17(24(26,27)28)4-7-20(16)32-11-15(9-22(33)34)19-6-5-18(25)10-21(19)32/h4-8,10-11,14H,2-3,9,12H2,1H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035075
PNG
(CHEMBL3338283)
Show SMILES Cc1nnc(C)n1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(Cc3ccccc3)nc12
Show InChI InChI=1S/C28H27N5O2/c1-18-9-12-26(23(13-18)17-32-19(2)30-31-20(32)3)33-16-22(15-27(34)35)25-11-10-24(29-28(25)33)14-21-7-5-4-6-8-21/h4-13,16H,14-15,17H2,1-3H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035090
PNG
(CHEMBL3338298)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(Cc3ccccc3)nc12
Show InChI InChI=1S/C30H26ClN3O3/c1-18-26(29(37-33-18)20-7-8-20)15-21-14-23(31)9-12-27(21)34-17-22(16-28(35)36)25-11-10-24(32-30(25)34)13-19-5-3-2-4-6-19/h2-6,9-12,14,17,20H,7-8,13,15-16H2,1H3,(H,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035033
PNG
(CHEMBL3338154)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)NCCc1ccccc1)C(=O)C1CC1
Show InChI InChI=1S/C32H34N4O4/c1-3-35(32(40)23-10-11-23)19-26-17-24(31(39)33-16-15-22-7-5-4-6-8-22)12-14-28(26)36-20-25(18-29(37)38)27-13-9-21(2)34-30(27)36/h4-9,12-14,17,20,23H,3,10-11,15-16,18-19H2,1-2H3,(H,33,39)(H,37,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035078
PNG
(CHEMBL3338286)
Show SMILES Cc1nnc(C2CC2)n1Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C24H20F4N4O2/c1-13-29-30-23(14-2-3-14)31(13)12-16-8-17(24(26,27)28)4-7-20(16)32-11-15(9-22(33)34)19-6-5-18(25)10-21(19)32/h4-8,10-11,14H,2-3,9,12H2,1H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035080
PNG
(CHEMBL3338288)
Show SMILES Cc1nnc(CCc2ccccc2)n1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C28H26ClN5O2/c1-18-8-11-24-21(15-27(35)36)16-34(28(24)30-18)25-12-10-23(29)14-22(25)17-33-19(2)31-32-26(33)13-9-20-6-4-3-5-7-20/h3-8,10-12,14,16H,9,13,15,17H2,1-2H3,(H,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035092
PNG
(CHEMBL3338300)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(Cl)cc3Cc3c(noc3C3CC3)C3CC3)c2n1
Show InChI InChI=1S/C26H24ClN3O3/c1-14-2-8-20-18(12-23(31)32)13-30(26(20)28-14)22-9-7-19(27)10-17(22)11-21-24(15-3-4-15)29-33-25(21)16-5-6-16/h2,7-10,13,15-16H,3-6,11-12H2,1H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035037
PNG
(CHEMBL3338268)
Show SMILES Cc1cnn(C)c1Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C22H21FN4O2/c1-13-11-24-26(3)20(13)9-15-8-17(23)5-7-19(15)27-12-16(10-21(28)29)18-6-4-14(2)25-22(18)27/h4-8,11-12H,9-10H2,1-3H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035020
PNG
(CHEMBL3338271)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(C)=O
Show InChI InChI=1S/C22H22F3N3O3/c1-4-27(14(3)29)11-16-9-17(22(23,24)25)6-8-19(16)28-12-15(10-20(30)31)18-7-5-13(2)26-21(18)28/h5-9,12H,4,10-11H2,1-3H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035079
PNG
(CHEMBL3338287)
Show SMILES Cc1nnc(Cc2ccccc2)n1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C27H24ClN5O2/c1-17-8-10-23-20(14-26(34)35)15-33(27(23)29-17)24-11-9-22(28)13-21(24)16-32-18(2)30-31-25(32)12-19-6-4-3-5-7-19/h3-11,13,15H,12,14,16H2,1-2H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50397641
PNG
(CHEMBL2181754)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)ccc1OC)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H24F3NO4/c1-3-27(22(30)15-5-6-15)13-16-12-17(23(24,25)26)7-8-18(16)19-10-14(11-21(28)29)4-9-20(19)31-2/h4,7-10,12,15H,3,5-6,11,13H2,1-2H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035039
PNG
(CHEMBL3338270)
Show SMILES Cc1nnc(C)n1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C22H23N5O2/c1-13-5-8-20(18(9-13)12-26-15(3)24-25-16(26)4)27-11-17(10-21(28)29)19-7-6-14(2)23-22(19)27/h5-9,11H,10,12H2,1-4H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035084
PNG
(CHEMBL3338292)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(F)ccc1-c1cn(CC(O)=O)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C25H20F4N2O3/c1-13-19(24(34-30-13)14-2-3-14)9-15-8-17(26)5-6-18(15)21-11-31(12-23(32)33)22-7-4-16(10-20(21)22)25(27,28)29/h4-8,10-11,14H,2-3,9,12H2,1H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035082
PNG
(CHEMBL3338290)
Show SMILES Cc1noc(C)c1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C23H18F4N2O3/c1-12-18(13(2)32-28-12)8-14-7-15(23(25,26)27)3-5-17(14)20-10-29(11-22(30)31)21-6-4-16(24)9-19(20)21/h3-7,9-10H,8,11H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035087
PNG
(CHEMBL3338295)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H19F6N3O3/c1-12-17(23(37-33-12)13-2-3-13)9-14-8-15(24(26,27)28)4-5-16(14)18-10-34(11-21(35)36)19-6-7-20(25(29,30)31)32-22(18)19/h4-8,10,13H,2-3,9,11H2,1H3,(H,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035085
PNG
(CHEMBL3338293)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-c1cc(CC(O)=O)n2ccc(C)nc12)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-13-7-8-31-18(12-22(32)33)11-21(24(31)29-13)19-6-5-17(25(26,27)28)9-16(19)10-20-14(2)30-34-23(20)15-3-4-15/h5-9,11,15H,3-4,10,12H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035035
PNG
(CHEMBL3338263)
Show SMILES COc1ccc(CC(O)=O)cc1-c1ccc(cc1Cn1c(C)nnc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N3O3/c1-13-27-28-22(15-4-5-15)29(13)12-16-11-17(23(24,25)26)6-7-18(16)19-9-14(10-21(30)31)3-8-20(19)32-2/h3,6-9,11,15H,4-5,10,12H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035069
PNG
(CHEMBL3338277)
Show SMILES Cc1ccc(c(Cn2ccnc2-c2ccccc2)c1)-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C27H24N4O2/c1-18-8-11-24(31-17-21(15-25(32)33)23-10-9-19(2)29-27(23)31)22(14-18)16-30-13-12-28-26(30)20-6-4-3-5-7-20/h3-14,17H,15-16H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035083
PNG
(CHEMBL3338291)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C25H20F4N2O3/c1-13-19(24(34-30-13)14-2-3-14)9-15-8-16(25(27,28)29)4-6-18(15)21-11-31(12-23(32)33)22-7-5-17(26)10-20(21)22/h4-8,10-11,14H,2-3,9,12H2,1H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035084
PNG
(CHEMBL3338292)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(F)ccc1-c1cn(CC(O)=O)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C25H20F4N2O3/c1-13-19(24(34-30-13)14-2-3-14)9-15-8-17(26)5-6-18(15)21-11-31(12-23(32)33)22-7-4-16(10-20(21)22)25(27,28)29/h4-8,10-11,14H,2-3,9,12H2,1H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035036
PNG
(CHEMBL3338267)
Show SMILES CCCc1nc2ccccc2n1Cc1ccccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C27H26N4O2/c1-3-8-25-29-22-10-5-7-12-24(22)30(25)16-19-9-4-6-11-23(19)31-17-20(15-26(32)33)21-14-13-18(2)28-27(21)31/h4-7,9-14,17H,3,8,15-16H2,1-2H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035087
PNG
(CHEMBL3338295)
Show SMILES Cc1noc(C2CC2)c1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H19F6N3O3/c1-12-17(23(37-33-12)13-2-3-13)9-14-8-15(24(26,27)28)4-5-16(14)18-10-34(11-21(35)36)19-6-7-20(25(29,30)31)32-22(18)19/h4-8,10,13H,2-3,9,11H2,1H3,(H,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 54n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035076
PNG
(CHEMBL3338284)
Show SMILES Cc1nnc(C2CC2)n1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C23H22ClN5O2/c1-13-3-7-19-16(10-21(30)31)11-29(23(19)25-13)20-8-6-18(24)9-17(20)12-28-14(2)26-27-22(28)15-4-5-15/h3,6-9,11,15H,4-5,10,12H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035091
PNG
(CHEMBL3338299)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3Cc3c(noc3C3CC3)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C27H24F3N3O3/c1-14-2-8-20-18(12-23(34)35)13-33(26(20)31-14)22-9-7-19(27(28,29)30)10-17(22)11-21-24(15-3-4-15)32-36-25(21)16-5-6-16/h2,7-10,13,15-16H,3-6,11-12H2,1H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescen...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035073
PNG
(CHEMBL3338281)
Show SMILES Cc1cnn(C)c1Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F
Show InChI InChI=1S/C23H19F4N3O2/c1-13-10-28-29(2)21(13)8-14-7-15(23(25,26)27)3-5-17(14)19-11-30(12-22(31)32)20-6-4-16(24)9-18(19)20/h3-7,9-11H,8,12H2,1-2H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035065
PNG
(CHEMBL3338273)
Show SMILES Cc1cnnn1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C21H21N5O2/c1-13-4-7-19(17(8-13)12-26-15(3)10-22-24-26)25-11-16(9-20(27)28)18-6-5-14(2)23-21(18)25/h4-8,10-11H,9,12H2,1-3H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035071
PNG
(CHEMBL3338279)
Show SMILES CC(C)c1ncncc1Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C24H23ClN4O2/c1-14(2)23-17(11-26-13-27-23)8-16-9-19(25)5-7-21(16)29-12-18(10-22(30)31)20-6-4-15(3)28-24(20)29/h4-7,9,11-14H,8,10H2,1-3H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035068
PNG
(CHEMBL3338276)
Show SMILES Cc1nccn1Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C22H22N4O2/c1-14-4-7-20(18(10-14)12-25-9-8-23-16(25)3)26-13-17(11-21(27)28)19-6-5-15(2)24-22(19)26/h4-10,13H,11-12H2,1-3H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035067
PNG
(CHEMBL3338275)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccccc3Cn3ccnc3)c2n1
Show InChI InChI=1S/C20H18N4O2/c1-14-6-7-17-16(10-19(25)26)12-24(20(17)22-14)18-5-3-2-4-15(18)11-23-9-8-21-13-23/h2-9,12-13H,10-11H2,1H3,(H,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 580n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035072
PNG
(CHEMBL3338280)
Show SMILES Cc1ccc(c(Cc2ccnn2Cc2ccccc2)c1)-n1cc(CC(O)=O)c2ccc(C)nc12
Show InChI InChI=1S/C28H26N4O2/c1-19-8-11-26(31-18-23(16-27(33)34)25-10-9-20(2)30-28(25)31)22(14-19)15-24-12-13-29-32(24)17-21-6-4-3-5-7-21/h3-14,18H,15-17H2,1-2H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035070
PNG
(CHEMBL3338278)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(Cl)cc3Cc3cncnc3)c2n1
Show InChI InChI=1S/C21H17ClN4O2/c1-13-2-4-18-16(8-20(27)28)11-26(21(18)25-13)19-5-3-17(22)7-15(19)6-14-9-23-12-24-10-14/h2-5,7,9-12H,6,8H2,1H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035040
PNG
(CHEMBL3338272)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccccc3Cn3ccnn3)c2n1
Show InChI InChI=1S/C19H17N5O2/c1-13-6-7-16-15(10-18(25)26)12-24(19(16)21-13)17-5-3-2-4-14(17)11-23-9-8-20-22-23/h2-9,12H,10-11H2,1H3,(H,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035066
PNG
(CHEMBL3338274)
Show SMILES OC(=O)Cn1cc(-c2ccc(cc2Cc2ocnc2C2CC2)C(F)(F)F)c2cc(F)ccc12
Show InChI InChI=1S/C24H18F4N2O3/c25-16-4-6-20-18(9-16)19(10-30(20)11-22(31)32)17-5-3-15(24(26,27)28)7-14(17)8-21-23(13-1-2-13)29-12-33-21/h3-7,9-10,12-13H,1-2,8,11H2,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgamma...

Bioorg Med Chem Lett 24: 5127-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.028
BindingDB Entry DOI: 10.7270/Q27P911Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%