Affinity Data by PubMed id=25455492

PubMed code 25455492

Found 22 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50005711 (CHEBI:46024 \| GNF-Pf-1011 \| TRICHOSTATIN \| Trichos...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50036932 (CHEMBL1478023 \| US11866416, Compound SN-II-118) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50036932 (CHEMBL1478023 \| US11866416, Compound SN-II-118) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50036932 (CHEMBL1478023 \| US11866416, Compound SN-II-118) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50036880 (CHEMBL199974) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50036933 (CHEMBL3355256) Show SMILES Oc1cccc(\C=C2/Oc3ccccc3C2=O)c1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50439491 (AUREUSIDIN) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50036933 (CHEMBL3355256) Show SMILES Oc1cccc(\C=C2/Oc3ccccc3C2=O)c1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50036933 (CHEMBL3355256) Show SMILES Oc1cccc(\C=C2/Oc3ccccc3C2=O)c1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50036933 (CHEMBL3355256) Show SMILES Oc1cccc(\C=C2/Oc3ccccc3C2=O)c1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50036932 (CHEMBL1478023 \| US11866416, Compound SN-II-118) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50439491 (AUREUSIDIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50439491 (AUREUSIDIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50036934 (3'',4,4'',6-Tetra(Methoxymethyl)-Aurone \| CHEMBL59...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50439491 (AUREUSIDIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (Homo sapiens (Human))	BDBM50036936 (3'',4''-Dimethoxy-Aurone \| 3',4'-DIMETHOXY-AURONE ...) Show SMILES COc1ccc(\C=C2/Oc3ccccc3C2=O)cc1OC Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50036880 (CHEMBL199974) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50036880 (CHEMBL199974) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50036880 (CHEMBL199974) Show SMILES Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assay				Bioorg Med Chem Lett 24: 5497-501 (2015) Article DOI: 10.1016/j.bmcl.2014.10.019 BindingDB Entry DOI: 10.7270/Q2X3502T
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%