Found 113 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50402937
(CHEMBL2206221)Show SMILES OCC1CCN(CC1)c1nccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C23H23N5O2S/c29-15-16-9-13-28(14-10-16)21-22(25-12-11-24-21)30-18-7-5-17(6-8-18)26-23-27-19-3-1-2-4-20(19)31-23/h1-8,11-12,16,29H,9-10,13-15H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 208 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 503 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 581 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50037294
(CHEMBL3356650)Show SMILES OCC1CCN(CC1)c1cccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-9-12-26(13-10-17)21-6-3-11-24-23(21)29-19-14-27(15-19)22-8-7-18-4-1-2-5-20(18)25-22/h1-8,11,17,19,28H,9-10,12-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98892
(US8497265, 218 | US8497265, 241)Show SMILES N#CC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H22N6O/c23-13-16-7-11-27(12-8-16)21-22(25-10-9-24-21)29-18-14-28(15-18)20-6-5-17-3-1-2-4-19(17)26-20/h1-6,9-10,16,18H,7-8,11-12,14-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99004
(US8497265, 460)Show SMILES Cc1cc(ccn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H19N5O/c1-15-12-17(8-9-23-15)21-22(25-11-10-24-21)28-18-13-27(14-18)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98992
(US8497265, 448)Show SMILES C1C(CN1c1ccc2ccccc2n1)Oc1nccnc1-c1ccc2scnc2c1 Show InChI InChI=1S/C23H17N5OS/c1-2-4-18-15(3-1)6-8-21(27-18)28-12-17(13-28)29-23-22(24-9-10-25-23)16-5-7-20-19(11-16)26-14-30-20/h1-11,14,17H,12-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99007
(US8497265, 463)Show SMILES Cc1ccc(cn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H19N5O/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)28-18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98996
(US8497265, 452)Show SMILES OCc1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H20N4O2/c28-15-16-5-7-18(8-6-16)22-23(25-12-11-24-22)29-19-13-27(14-19)21-10-9-17-3-1-2-4-20(17)26-21/h1-12,19,28H,13-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98890
(US8497265, 216)Show SMILES NC(=O)C1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H24N6O2/c23-20(29)16-7-11-27(12-8-16)21-22(25-10-9-24-21)30-17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98999
(US8497265, 455)Show InChI InChI=1S/C21H17N5O/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)27-21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98960
(US8497265, 415)Show InChI InChI=1S/C21H17N5O/c1-2-4-18-15(3-1)5-6-19(25-18)26-13-17(14-26)27-21-20(23-11-12-24-21)16-7-9-22-10-8-16/h1-12,17H,13-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98894
(US8497265, 220)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ncc2ccccc2n1 Show InChI InChI=1S/C21H24N6O2/c28-14-15-5-9-26(10-6-15)19-20(23-8-7-22-19)29-17-12-27(13-17)21-24-11-16-3-1-2-4-18(16)25-21/h1-4,7-8,11,15,17,28H,5-6,9-10,12-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98914
(US8497265, 240)Show SMILES OCCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H27N5O2/c29-14-9-17-7-12-27(13-8-17)22-23(25-11-10-24-22)30-19-15-28(16-19)21-6-5-18-3-1-2-4-20(18)26-21/h1-6,10-11,17,19,29H,7-9,12-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50037293
(CHEMBL3356306)Show InChI InChI=1S/C20H23N5O2S/c26-13-14-5-9-24(10-6-14)18-19(22-8-7-21-18)27-15-11-25(12-15)20-23-16-3-1-2-4-17(16)28-20/h1-4,7-8,14-15,26H,5-6,9-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98877
(US8497265, 203)Show InChI InChI=1S/C20H21N5O2/c1-2-4-17-15(3-1)5-6-18(23-17)25-13-16(14-25)27-20-19(21-7-8-22-20)24-9-11-26-12-10-24/h1-8,16H,9-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98893
(US8497265, 219)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1cnc2ccccc2n1 Show InChI InChI=1S/C21H24N6O2/c28-14-15-5-9-26(10-6-15)20-21(23-8-7-22-20)29-16-12-27(13-16)19-11-24-17-3-1-2-4-18(17)25-19/h1-4,7-8,11,15-16,28H,5-6,9-10,12-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98872
(US8497265, 198)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM98898
(US8497265, 224)Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98896
(US8497265, 222)Show SMILES OCC1CCN(CC1)c1nccnc1O[C@@H]1CCN(C1)c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C23H27N5O2/c29-16-17-7-12-27(13-8-17)22-23(25-11-10-24-22)30-19-9-14-28(15-19)21-6-5-18-3-1-2-4-20(18)26-21/h1-6,10-11,17,19,29H,7-9,12-16H2/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM98990
(US8497265, 446)Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM98891
(US8497265, 217 | US8497265, 239)Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM99145
(US8497265, 894)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM98933
(US8497265, 345)Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM99037
(US8497265, 677)Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98995
(US8497265, 451)Show SMILES OCc1cccc(c1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H20N4O2/c28-15-16-4-3-6-18(12-16)22-23(25-11-10-24-22)29-19-13-27(14-19)21-9-8-17-5-1-2-7-20(17)26-21/h1-12,19,28H,13-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98876
(US8497265, 202)Show InChI InChI=1S/C21H23N5O/c1-4-12-25(13-5-1)20-21(23-11-10-22-20)27-17-14-26(15-17)19-9-8-16-6-2-3-7-18(16)24-19/h2-3,6-11,17H,1,4-5,12-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98924
(US8497265, 250)Show InChI InChI=1S/C19H19N5O2/c25-14-9-24(10-14)18-19(21-8-7-20-18)26-15-11-23(12-15)17-6-5-13-3-1-2-4-16(13)22-17/h1-8,14-15,25H,9-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99001
(US8497265, 457)Show SMILES COC(=O)c1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H20N4O3/c1-30-24(29)18-8-6-17(7-9-18)22-23(26-13-12-25-22)31-19-14-28(15-19)21-11-10-16-4-2-3-5-20(16)27-21/h2-13,19H,14-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99000
(US8497265, 456)Show SMILES C1C(CN1c1ccc2ccccc2n1)Oc1nccnc1-c1cnc2ccccc2c1 Show InChI InChI=1S/C25H19N5O/c1-4-8-22-17(5-1)9-10-23(29-22)30-15-20(16-30)31-25-24(26-11-12-27-25)19-13-18-6-2-3-7-21(18)28-14-19/h1-14,20H,15-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98968
(US8497265, 424)Show InChI InChI=1S/C22H18N4O/c1-2-7-17(8-3-1)21-22(24-13-12-23-21)27-18-14-26(15-18)20-11-10-16-6-4-5-9-19(16)25-20/h1-13,18H,14-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98888
(US8497265, 214)Show InChI InChI=1S/C21H23N5O2/c27-14-15-7-10-25(11-15)20-21(23-9-8-22-20)28-17-12-26(13-17)19-6-5-16-3-1-2-4-18(16)24-19/h1-6,8-9,15,17,27H,7,10-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98997
(US8497265, 453)Show SMILES C1C(CN1c1ccc2ccccc2n1)Oc1nccnc1-c1cccc2ncccc12 Show InChI InChI=1S/C25H19N5O/c1-2-8-21-17(5-1)10-11-23(29-21)30-15-18(16-30)31-25-24(27-13-14-28-25)20-6-3-9-22-19(20)7-4-12-26-22/h1-14,18H,15-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98974
(US8497265, 430)Show SMILES CNC(=O)c1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H21N5O2/c1-25-23(30)18-8-6-17(7-9-18)22-24(27-13-12-26-22)31-19-14-29(15-19)21-11-10-16-4-2-3-5-20(16)28-21/h2-13,19H,14-15H2,1H3,(H,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98965
(US8497265, 421)Show SMILES N#Cc1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H17N5O/c24-13-16-5-7-18(8-6-16)22-23(26-12-11-25-22)29-19-14-28(15-19)21-10-9-17-3-1-2-4-20(17)27-21/h1-12,19H,14-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98897
(US8497265, 223)Show SMILES OCC1CCN(CC1)c1nccnc1O[C@H]1CCN(C1)c1ccc2ccccc2n1 |r| Show InChI InChI=1S/C23H27N5O2/c29-16-17-7-12-27(13-8-17)22-23(25-11-10-24-22)30-19-9-14-28(15-19)21-6-5-18-3-1-2-4-20(18)26-21/h1-6,10-11,17,19,29H,7-9,12-16H2/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98875
(US8497265, 201)Show InChI InChI=1S/C21H23N5O2/c27-16-7-11-25(12-8-16)20-21(23-10-9-22-20)28-17-13-26(14-17)19-6-5-15-3-1-2-4-18(15)24-19/h1-6,9-10,16-17,27H,7-8,11-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99031
(US8497265, 671)Show SMILES COC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H25N5O3/c1-30-23(29)27-12-8-17(9-13-27)21-22(25-11-10-24-21)31-18-14-28(15-18)20-7-6-16-4-2-3-5-19(16)26-20/h2-7,10-11,17-18H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98983
(US8497265, 439)Show InChI InChI=1S/C22H19N5O/c1-15-18(6-4-10-23-15)21-22(25-12-11-24-21)28-17-13-27(14-17)20-9-8-16-5-2-3-7-19(16)26-20/h2-12,17H,13-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98878
(US8497265, 204)Show InChI InChI=1S/C22H25N5O/c1-16-8-12-26(13-9-16)21-22(24-11-10-23-21)28-18-14-27(15-18)20-7-6-17-4-2-3-5-19(17)25-20/h2-7,10-11,16,18H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98966
(US8497265, 422)Show SMILES Cc1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H20N4O/c1-16-6-8-18(9-7-16)22-23(25-13-12-24-22)28-19-14-27(15-19)21-11-10-17-4-2-3-5-20(17)26-21/h2-13,19H,14-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99003
(US8497265, 459)Show InChI InChI=1S/C20H16N6O/c1-2-4-17-14(3-1)5-6-18(25-17)26-11-16(12-26)27-20-19(23-7-8-24-20)15-9-21-13-22-10-15/h1-10,13,16H,11-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98895
(US8497265, 221)Show SMILES COCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H27N5O2/c1-29-16-17-8-12-27(13-9-17)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-18-4-2-3-5-20(18)26-21/h2-7,10-11,17,19H,8-9,12-16H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM99032
(US8497265, 672)Show SMILES CS(=O)(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H25N5O3S/c1-31(28,29)27-12-8-17(9-13-27)21-22(24-11-10-23-21)30-18-14-26(15-18)20-7-6-16-4-2-3-5-19(16)25-20/h2-7,10-11,17-18H,8-9,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.66E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98920
(US8497265, 246)Show SMILES CN(C)C1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H28N6O/c1-27(2)18-9-13-28(14-10-18)22-23(25-12-11-24-22)30-19-15-29(16-19)21-8-7-17-5-3-4-6-20(17)26-21/h3-8,11-12,18-19H,9-10,13-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.43E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98961
(US8497265, 416)Show InChI InChI=1S/C21H17N5O/c1-2-6-17-15(5-1)8-9-19(25-17)26-13-16(14-26)27-21-20(23-11-12-24-21)18-7-3-4-10-22-18/h1-12,16H,13-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay |
Bioorg Med Chem 22: 6570-85 (2015)
Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q |
More data for this
Ligand-Target Pair | |
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