Found 21 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039850
(CHEMBL3357873)Show SMILES COc1ccc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cn1 Show InChI InChI=1S/C18H21N7O2/c1-10-22-16(25-17(19)23-10)13-7-11(18(2,3)26)8-21-15(13)24-12-5-6-14(27-4)20-9-12/h5-9,26H,1-4H3,(H,21,24)(H2,19,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125489
(US8772480, 353)Show SMILES COc1cncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)c1 Show InChI InChI=1S/C18H21N7O2/c1-10-22-16(25-17(19)23-10)14-5-11(18(2,3)26)7-21-15(14)24-12-6-13(27-4)9-20-8-12/h5-9,26H,1-4H3,(H,21,24)(H2,19,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125460
(US8772480, 314)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(O)C(F)(F)F)cc1F Show InChI InChI=1S/C17H15F4N7O2/c1-7-25-14(28-16(22)26-7)10-3-8(12(29)17(19,20)21)5-23-13(10)27-9-4-11(18)15(30-2)24-6-9/h3-6,12,29H,1-2H3,(H,23,27)(H2,22,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125488
(US8772480, 352)Show SMILES Cc1nc(N)nc(n1)-c1cc(cnc1Nc1cncc(F)c1)C(C)(C)O Show InChI InChI=1S/C17H18FN7O/c1-9-22-15(25-16(19)23-9)13-4-10(17(2,3)26)6-21-14(13)24-12-5-11(18)7-20-8-12/h4-8,26H,1-3H3,(H,21,24)(H2,19,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125443
(US8772480, 298)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C2(O)CC2)cc1F Show InChI InChI=1S/C18H18FN7O2/c1-9-23-15(26-17(20)24-9)12-5-10(18(27)3-4-18)7-21-14(12)25-11-6-13(19)16(28-2)22-8-11/h5-8,27H,3-4H2,1-2H3,(H,21,25)(H2,20,23,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125492
(US8772480, 356)Show SMILES Cc1nc(N)nc(n1)-c1cc(cnc1Nc1cncc(c1)S(=O)(=O)c1ccccc1)C(C)(C)O Show InChI InChI=1S/C23H23N7O3S/c1-14-27-21(30-22(24)28-14)19-9-15(23(2,3)31)11-26-20(19)29-16-10-18(13-25-12-16)34(32,33)17-7-5-4-6-8-17/h4-13,31H,1-3H3,(H,26,29)(H2,24,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125422
(US8772480, 273)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cc1F Show InChI InChI=1S/C18H20FN7O2/c1-9-23-15(26-17(20)24-9)12-5-10(18(2,3)27)7-21-14(12)25-11-6-13(19)16(28-4)22-8-11/h5-8,27H,1-4H3,(H,21,25)(H2,20,23,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125490
(US8772480, 354)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cc1C Show InChI InChI=1S/C19H23N7O2/c1-10-6-13(9-22-17(10)28-5)25-15-14(7-12(8-21-15)19(3,4)27)16-23-11(2)24-18(20)26-16/h6-9,27H,1-5H3,(H,21,25)(H2,20,23,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125486
(US8772480, 350)Show SMILES COc1cc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cnc1OC Show InChI InChI=1S/C19H23N7O3/c1-10-23-16(26-18(20)24-10)13-6-11(19(2,3)27)8-21-15(13)25-12-7-14(28-4)17(29-5)22-9-12/h6-9,27H,1-5H3,(H,21,25)(H2,20,23,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039948
(CHEMBL3357871)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)CO)cc1F |r| Show InChI InChI=1S/C18H20FN7O2/c1-9(8-27)11-4-13(16-23-10(2)24-18(20)26-16)15(21-6-11)25-12-5-14(19)17(28-3)22-7-12/h4-7,9,27H,8H2,1-3H3,(H,21,25)(H2,20,23,24,26)/t9-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50396808
(CHEMBL2170081 | US8772480, 148)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)N2CCN(CC2)S(C)(=O)=O)cc1F |r| Show InChI InChI=1S/C22H28FN9O3S/c1-13(31-5-7-32(8-6-31)36(4,33)34)15-9-17(20-27-14(2)28-22(24)30-20)19(25-11-15)29-16-10-18(23)21(35-3)26-12-16/h9-13H,5-8H2,1-4H3,(H,25,29)(H2,24,27,28,30)/t13-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039955
(CHEMBL3357864)Show InChI InChI=1S/C16H16FN7O2/c1-8-21-14(24-16(18)22-8)11-3-9(7-25)5-19-13(11)23-10-4-12(17)15(26-2)20-6-10/h3-6,25H,7H2,1-2H3,(H,19,23)(H2,18,21,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039950
(CHEMBL3357870)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)CO)cc1F |r| Show InChI InChI=1S/C18H20FN7O2/c1-9(8-27)11-4-13(16-23-10(2)24-18(20)26-16)15(21-6-11)25-12-5-14(19)17(28-3)22-7-12/h4-7,9,27H,8H2,1-3H3,(H,21,25)(H2,20,23,24,26)/t9-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039847
(CHEMBL3357877)Show SMILES CCc1cc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cnc1OC Show InChI InChI=1S/C20H25N7O2/c1-6-12-7-14(10-23-18(12)29-5)26-16-15(8-13(9-22-16)20(3,4)28)17-24-11(2)25-19(21)27-17/h7-10,28H,6H2,1-5H3,(H,22,26)(H2,21,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125491
(US8772480, 355)Show SMILES Cc1nc(N)nc(n1)-c1cc(cnc1Nc1cncc(c1)S(C)(=O)=O)C(C)(C)O Show InChI InChI=1S/C18H21N7O3S/c1-10-22-16(25-17(19)23-10)14-5-11(18(2,3)26)7-21-15(14)24-12-6-13(9-20-8-12)29(4,27)28/h5-9,26H,1-4H3,(H,21,24)(H2,19,22,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125456
(US8772480, 311)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)CO)cc1F Show InChI InChI=1S/C19H22FN7O2/c1-10-24-16(27-18(21)25-10)13-5-11(19(2,3)9-28)7-22-15(13)26-12-6-14(20)17(29-4)23-8-12/h5-8,28H,9H2,1-4H3,(H,22,26)(H2,21,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125403
(US8772480, 246)Show InChI InChI=1S/C15H14FN7O/c1-8-20-13(23-15(17)21-8)10-4-3-5-18-12(10)22-9-6-11(16)14(24-2)19-7-9/h3-7H,1-2H3,(H,18,22)(H2,17,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039846
(CHEMBL3358284)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cc1C(C)C Show InChI InChI=1S/C21H27N7O2/c1-11(2)15-8-14(10-24-19(15)30-6)27-17-16(7-13(9-23-17)21(4,5)29)18-25-12(3)26-20(22)28-18/h7-11,29H,1-6H3,(H,23,27)(H2,22,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039953
(CHEMBL3357865)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)O)cc1F |r| Show InChI InChI=1S/C17H18FN7O2/c1-8(26)10-4-12(15-22-9(2)23-17(19)25-15)14(20-6-10)24-11-5-13(18)16(27-3)21-7-11/h4-8,26H,1-3H3,(H,20,24)(H2,19,22,23,25)/t8-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM125484
(US8772480, 348)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)(C)O)cc1C(F)(F)F Show InChI InChI=1S/C19H20F3N7O2/c1-9-26-15(29-17(23)27-9)12-5-10(18(2,3)30)7-24-14(12)28-11-6-13(19(20,21)22)16(31-4)25-8-11/h5-8,30H,1-4H3,(H,24,28)(H2,23,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50039952
(CHEMBL3357866)Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)O)cc1F |r| Show InChI InChI=1S/C17H18FN7O2/c1-8(26)10-4-12(15-22-9(2)23-17(19)25-15)14(20-6-10)24-11-5-13(18)16(27-3)21-7-11/h4-8,26H,1-3H3,(H,20,24)(H2,19,22,23,25)/t8-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi... |
Bioorg Med Chem Lett 24: 5630-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS |
More data for this
Ligand-Target Pair | |
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