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PubMed code 2547074

Compile data set for download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50000780
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1...)
Show SMILES CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m0/s1
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0.890n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards kappa opioid receptor using [3H](-)-U-69,593 in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50000780
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1...)
Show SMILES CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m0/s1
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44n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
In vitro inhibition of rat liver dihydrofolate reductase.


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50017214
PNG
((-)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m0/s1
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81n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
In vitro inhibition of dihydrofolate reductase of Escherichia coli


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50000296
PNG
(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Show SMILES CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
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109n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
In vitro inhibition of rat liver dihydrofolate reductase.


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50008848
PNG
((+)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m1/s1
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118n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards sigma opioid receptor using [3H]DTG in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50017214
PNG
((-)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m0/s1
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167n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards kappa opioid receptor using [3H](-)-U-69,593 in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50008848
PNG
((+)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m1/s1
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221n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
In vitro inhibition of dihydrofolate reductase of Escherichia coli


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50017214
PNG
((-)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m0/s1
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250n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards sigma opioid receptor using [3H]DTG in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50000296
PNG
(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Show SMILES CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
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299n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
In vitro inhibition of rat liver dihydrofolate reductase.


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50000780
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1...)
Show SMILES CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m0/s1
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594n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards sigma opioid receptor using [3H](+)-3-PPP in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50000296
PNG
(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Show SMILES CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
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874n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards sigma opioid receptor using [3H](+)-3-PPP in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50000296
PNG
(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Show SMILES CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
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874n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
In vitro inhibition of Escherichia coli dihydrofolate reductase.


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50000296
PNG
(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Show SMILES CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
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1.30E+3n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards kappa opioid receptor using [3H]-BREM in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50008848
PNG
((+)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m1/s1
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2.72E+3n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards kappa opioid receptor using [3H](-)-U-69,593 in guinea pig ileum


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50017214
PNG
((-)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m0/s1
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3.73E+3n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Dopamine receptor D2 using [3H]SULP in rat


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50008848
PNG
((+)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidi...)
Show SMILES CN([C@@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18+/m1/s1
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1.40E+4n/an/an/an/an/an/an/an/a



National Institute of Digestive

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Dopamine receptor D2 using [3H]SULP in rat


J Med Chem 32: 1996-2002 (1989)


BindingDB Entry DOI: 10.7270/Q2ZG6STP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%