Affinity Data by PubMed id=25626527

PubMed code 25626527

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50018011 (Aubagio \| CHEBI:68540 \| HMR-1726 \| TERIFLUNOMIDE) Show SMILES C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	8.0	n/a
Chinese Academy of Sciences					Assay Description Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 �C in 50 mM Tris-HCl, 0.1% Triton X-...				Chem Biol Drug Des 86: 626-36 (2015) Article DOI: 10.1111/cbdd.12530 BindingDB Entry DOI: 10.7270/Q2JH3JXM
Chinese Academy of Sciences					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM163707 (Cyclo L-OH-Pro-L-Phe (Fr. 1-4)) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	773	n/a	n/a	n/a	n/a	8.0	n/a
Chinese Academy of Sciences					Assay Description Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 �C in 50 mM Tris-HCl, 0.1% Triton X-...				Chem Biol Drug Des 86: 626-36 (2015) Article DOI: 10.1111/cbdd.12530 BindingDB Entry DOI: 10.7270/Q2JH3JXM
Chinese Academy of Sciences					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM163711 (Cyclo L-Pro-L-Val (Fr. 2-1)) Show SMILES CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C1=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	8.0	n/a
Chinese Academy of Sciences					Assay Description Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 �C in 50 mM Tris-HCl, 0.1% Triton X-...				Chem Biol Drug Des 86: 626-36 (2015) Article DOI: 10.1111/cbdd.12530 BindingDB Entry DOI: 10.7270/Q2JH3JXM
Chinese Academy of Sciences					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM163709 (Cyclo L-Pro-L-Leu (Fr. 1-6)) Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C1=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	8.0	n/a
Chinese Academy of Sciences					Assay Description Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 �C in 50 mM Tris-HCl, 0.1% Triton X-...				Chem Biol Drug Des 86: 626-36 (2015) Article DOI: 10.1111/cbdd.12530 BindingDB Entry DOI: 10.7270/Q2JH3JXM
Chinese Academy of Sciences					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM163710 (Cyclo L-Pro-L-Phe (Fr. 2-2)) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	8.0	n/a
Chinese Academy of Sciences					Assay Description Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 �C in 50 mM Tris-HCl, 0.1% Triton X-...				Chem Biol Drug Des 86: 626-36 (2015) Article DOI: 10.1111/cbdd.12530 BindingDB Entry DOI: 10.7270/Q2JH3JXM
Chinese Academy of Sciences					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM163708 (Cyclo L-Pro-L-Ile (Fr. 1-5)) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	8.0	n/a
Chinese Academy of Sciences					Assay Description Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 �C in 50 mM Tris-HCl, 0.1% Triton X-...				Chem Biol Drug Des 86: 626-36 (2015) Article DOI: 10.1111/cbdd.12530 BindingDB Entry DOI: 10.7270/Q2JH3JXM
Chinese Academy of Sciences					More data for this Ligand-Target Pair

* indicates data uncertainty>20%