Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079528
(CHEMBL3417316)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)NCCO |r,c:24,t:14,16,19| Show InChI InChI=1S/C31H43NO4/c1-19-20-7-8-23-29(4,21(20)17-22(34)25(19)35)12-14-31(6)24-18-28(3,26(36)32-15-16-33)10-9-27(24,2)11-13-30(23,31)5/h7-8,17,24,33,35H,9-16,18H2,1-6H3,(H,32,36)/t24-,27-,28-,29+,30-,31+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079529
(CHEMBL3417317)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)NC(O)CC |r,c:24,t:14,16,19| Show InChI InChI=1S/C32H45NO4/c1-8-25(35)33-27(37)29(4)12-11-28(3)13-15-31(6)23-10-9-20-19(2)26(36)22(34)17-21(20)30(23,5)14-16-32(31,7)24(28)18-29/h9-10,17,24-25,35-36H,8,11-16,18H2,1-7H3,(H,33,37)/t24-,25?,28-,29-,30+,31-,32+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50126186
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50071058
((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...)Show SMILES C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17| Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,30-31H,1,9-14,16H2,2-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079533
(CHEMBL3417322)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)N1CCN(CCN(C)C)CC1 |r,c:24,t:14,16,19| Show InChI InChI=1S/C37H55N3O3/c1-25-26-9-10-29-35(4,27(26)23-28(41)31(25)42)14-16-37(6)30-24-34(3,12-11-33(30,2)13-15-36(29,37)5)32(43)40-21-19-39(20-22-40)18-17-38(7)8/h9-10,23,30,42H,11-22,24H2,1-8H3/t30-,33-,34-,35+,36-,37+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079532
(CHEMBL3417321)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)N1CCN(CCO)CC1 |r,c:24,t:14,16,19| Show InChI InChI=1S/C35H50N2O4/c1-23-24-7-8-27-33(4,25(24)21-26(39)29(23)40)12-14-35(6)28-22-32(3,10-9-31(28,2)11-13-34(27,35)5)30(41)37-17-15-36(16-18-37)19-20-38/h7-8,21,28,38,40H,9-20,22H2,1-6H3/t28-,31-,32-,33+,34-,35+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079530
(CHEMBL3417319)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)N1CCOCC1 |r,c:24,t:14,16,19| Show InChI InChI=1S/C33H45NO4/c1-21-22-7-8-25-31(4,23(22)19-24(35)27(21)36)12-14-33(6)26-20-30(3,28(37)34-15-17-38-18-16-34)10-9-29(26,2)11-13-32(25,33)5/h7-8,19,26,36H,9-18,20H2,1-6H3/t26-,29-,30-,31+,32-,33+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079525
(CHEMBL3417314)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)NC |r,c:24,t:14,16,19| Show InChI InChI=1S/C30H41NO3/c1-18-19-8-9-22-28(4,20(19)16-21(32)24(18)33)13-15-30(6)23-17-27(3,25(34)31-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,33H,10-15,17H2,1-7H3,(H,31,34)/t23-,26-,27-,28+,29-,30+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079531
(CHEMBL3417320)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)N1CCN(CCN2CCOCC2)CC1 |r,c:24,t:14,16,19| Show InChI InChI=1S/C39H57N3O4/c1-27-28-7-8-31-37(4,29(28)25-30(43)33(27)44)12-14-39(6)32-26-36(3,10-9-35(32,2)11-13-38(31,39)5)34(45)42-19-17-40(18-20-42)15-16-41-21-23-46-24-22-41/h7-8,25,32,44H,9-24,26H2,1-6H3/t32-,35-,36-,37+,38-,39+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079524
(CHEMBL3417313)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)OCC |r,c:24,t:14,16,19| Show InChI InChI=1S/C31H42O4/c1-8-35-26(34)28(4)12-11-27(3)13-15-30(6)23-10-9-20-19(2)25(33)22(32)17-21(20)29(23,5)14-16-31(30,7)24(27)18-28/h9-10,17,24,33H,8,11-16,18H2,1-7H3/t24-,27-,28-,29+,30-,31+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50079526
(CHEMBL3417315)Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)N(C)C |r,c:24,t:14,16,19| Show InChI InChI=1S/C31H43NO3/c1-19-20-9-10-23-29(4,21(20)17-22(33)25(19)34)14-16-31(6)24-18-28(3,26(35)32(7)8)12-11-27(24,2)13-15-30(23,31)5/h9-10,17,24,34H,11-16,18H2,1-8H3/t24-,27-,28-,29+,30-,31+/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA |
Eur J Med Chem 95: 166-73 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.039
BindingDB Entry DOI: 10.7270/Q2W097NH |
More data for this
Ligand-Target Pair | |
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